ID DHRS7_DROME Reviewed; 326 AA. AC Q9Y140; DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 11-JUN-2014, entry version 96. DE RecName: Full=Dehydrogenase/reductase SDR family protein 7-like; DE EC=1.1.-.-; GN ORFNames=CG7601; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=10731138; DOI=10.1126/science.287.5461.2222; RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., RA Stapleton M., Harvey D.A.; RT "A Drosophila complementary DNA resource."; RL Science 287:2222-2224(2000). CC -!- FUNCTION: Putative oxidoreductase (Potential). CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass type II CC membrane protein (Potential). CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases CC (SDR) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF56927.1; -; Genomic_DNA. DR EMBL; AF145631; AAD38606.1; -; mRNA. DR RefSeq; NP_651717.1; NM_143460.3. DR UniGene; Dm.3158; -. DR ProteinModelPortal; Q9Y140; -. DR SMR; Q9Y140; 53-294. DR BioGrid; 68366; 4. DR STRING; 7227.FBpp0084910; -. DR PaxDb; Q9Y140; -. DR PRIDE; Q9Y140; -. DR EnsemblMetazoa; FBtr0085544; FBpp0084910; FBgn0027583. DR GeneID; 43502; -. DR KEGG; dme:Dmel_CG7601; -. DR UCSC; CG7601-RA; d. melanogaster. DR FlyBase; FBgn0027583; CG7601. DR eggNOG; COG0300; -. DR GeneTree; ENSGT00740000115336; -. DR InParanoid; Q9Y140; -. DR KO; K11166; -. DR OMA; QGKFAIP; -. DR OrthoDB; EOG7W6WM5; -. DR PhylomeDB; Q9Y140; -. DR GenomeRNAi; 43502; -. DR NextBio; 834271; -. DR PRO; PR:Q9Y140; -. DR Bgee; Q9Y140; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.720; -; 1. DR InterPro; IPR002198; DH_sc/Rdtase_SDR. DR InterPro; IPR002347; Glc/ribitol_DH. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR020904; Sc_DH/Rdtase_CS. DR Pfam; PF00106; adh_short; 1. DR PIRSF; PIRSF000126; 11-beta-HSD1; 1. DR PRINTS; PR00081; GDHRDH. DR PRINTS; PR00080; SDRFAMILY. DR PROSITE; PS00061; ADH_SHORT; 1. PE 2: Evidence at transcript level; KW Complete proteome; Membrane; NAD; NADP; Oxidoreductase; Peroxisome; KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. FT CHAIN 1 326 Dehydrogenase/reductase SDR family FT protein 7-like. FT /FTId=PRO_0000312113. FT TOPO_DOM 1 17 Cytoplasmic (Potential). FT TRANSMEM 18 38 Helical; Signal-anchor for type II FT membrane protein; (Potential). FT TOPO_DOM 39 326 Peroxisomal (Potential). FT NP_BIND 57 81 NAD or NADP (By similarity). FT ACT_SITE 206 206 Proton acceptor (By similarity). FT BINDING 193 193 Substrate (Potential). SQ SEQUENCE 326 AA; 35744 MW; 0A70A38F2AB2BD6D CRC64; MKVQDMDKCA PSSDWNVLYW VLGTVLMPVA LPLAIINIWQ RFQAQKFRNQ LPGKVVLITG ASSGLGESLA HVFYRAGCRV ILAARRTQEL ERVKKDLLAL DVDPAYPPTV LPLDLAELNS IPEFVTRVLA VYNQVDILIN NGGISVRADV ASTAVDVDLK VMVVNYFGSV ALTKALLPSM VKRGSGHICF ISSVQGKFAI PQRAAYSASK HAMQAFADSL RAEVANKNIN VSCVSPGYIR TQLSLNALTG SGSSYGKVDE TTAKGMSPDK LAERILQCIL RKEPDIIVSD VQAKIAYYLR HLCPSLYFWI MAKRAVKLEN AEKKST //