ID DHRS7_DROME Reviewed; 326 AA. AC Q9Y140; DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 12-AUG-2020, entry version 135. DE RecName: Full=Dehydrogenase/reductase SDR family protein 7-like; DE EC=1.1.-.-; GN ORFNames=CG7601; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=10731138; DOI=10.1126/science.287.5461.2222; RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M., RA Harvey D.A.; RT "A Drosophila complementary DNA resource."; RL Science 287:2222-2224(2000). CC -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Single-pass CC type II membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF56927.1; -; Genomic_DNA. DR EMBL; AF145631; AAD38606.1; -; mRNA. DR RefSeq; NP_651717.1; NM_143460.4. DR SMR; Q9Y140; -. DR BioGRID; 68366; 5. DR STRING; 7227.FBpp0084910; -. DR PaxDb; Q9Y140; -. DR PRIDE; Q9Y140; -. DR EnsemblMetazoa; FBtr0085544; FBpp0084910; FBgn0027583. DR GeneID; 43502; -. DR KEGG; dme:Dmel_CG7601; -. DR UCSC; CG7601-RA; d. melanogaster. DR FlyBase; FBgn0027583; CG7601. DR eggNOG; KOG1205; Eukaryota. DR GeneTree; ENSGT00940000170022; -. DR HOGENOM; CLU_010194_2_1_1; -. DR InParanoid; Q9Y140; -. DR KO; K11166; -. DR OMA; SLYFWIM; -. DR OrthoDB; 1313182at2759; -. DR PhylomeDB; Q9Y140; -. DR Reactome; R-DME-75896; Plasmalogen biosynthesis. DR BioGRID-ORCS; 43502; 1 hit in 5 CRISPR screens. DR GenomeRNAi; 43502; -. DR PRO; PR:Q9Y140; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0027583; Expressed in thoracico-abdominal ganglion (Drosophila) and 38 other tissues. DR Genevisible; Q9Y140; DM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR020904; Sc_DH/Rdtase_CS. DR InterPro; IPR002347; SDR_fam. DR Pfam; PF00106; adh_short; 1. DR PRINTS; PR00081; GDHRDH. DR PRINTS; PR00080; SDRFAMILY. DR SUPFAM; SSF51735; SSF51735; 1. DR PROSITE; PS00061; ADH_SHORT; 1. PE 2: Evidence at transcript level; KW Membrane; NAD; NADP; Oxidoreductase; Peroxisome; Reference proteome; KW Signal-anchor; Transmembrane; Transmembrane helix. FT CHAIN 1..326 FT /note="Dehydrogenase/reductase SDR family protein 7-like" FT /id="PRO_0000312113" FT TOPO_DOM 1..17 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 18..38 FT /note="Helical; Signal-anchor for type II membrane protein" FT /evidence="ECO:0000255" FT TOPO_DOM 39..326 FT /note="Peroxisomal" FT /evidence="ECO:0000255" FT NP_BIND 57..81 FT /note="NAD or NADP" FT /evidence="ECO:0000250" FT ACT_SITE 206 FT /note="Proton acceptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001" FT BINDING 193 FT /note="Substrate" FT /evidence="ECO:0000255" SQ SEQUENCE 326 AA; 35744 MW; 0A70A38F2AB2BD6D CRC64; MKVQDMDKCA PSSDWNVLYW VLGTVLMPVA LPLAIINIWQ RFQAQKFRNQ LPGKVVLITG ASSGLGESLA HVFYRAGCRV ILAARRTQEL ERVKKDLLAL DVDPAYPPTV LPLDLAELNS IPEFVTRVLA VYNQVDILIN NGGISVRADV ASTAVDVDLK VMVVNYFGSV ALTKALLPSM VKRGSGHICF ISSVQGKFAI PQRAAYSASK HAMQAFADSL RAEVANKNIN VSCVSPGYIR TQLSLNALTG SGSSYGKVDE TTAKGMSPDK LAERILQCIL RKEPDIIVSD VQAKIAYYLR HLCPSLYFWI MAKRAVKLEN AEKKST //