ID Q9XZ68_DROME Unreviewed; 347 AA. AC Q9XZ68; DT 01-NOV-1999, integrated into UniProtKB/TrEMBL. DT 01-NOV-1999, sequence version 1. DT 29-MAY-2024, entry version 196. DE RecName: Full=Geranylgeranyl transferase type-2 subunit beta {ECO:0000256|RuleBase:RU365076}; DE EC=2.5.1.60 {ECO:0000256|RuleBase:RU365076}; GN Name=RabGGTb {ECO:0000313|EMBL:AAF51183.1, GN ECO:0000313|FlyBase:FBgn0028970}; GN Synonyms=beta-ggt-II {ECO:0000313|FlyBase:FBgn0028970}, betaggt GN {ECO:0000313|EMBL:AAF51183.1}, betaggt II GN {ECO:0000313|EMBL:AAF51183.1}, betaggt-II GN {ECO:0000313|EMBL:AAF51183.1}, Dmel\CG18627 GN {ECO:0000313|EMBL:AAF51183.1}, GGT-II beta GN {ECO:0000313|EMBL:AAF51183.1}, RabGGTbeta GN {ECO:0000313|EMBL:AAF51183.1}; GN ORFNames=CG18627 {ECO:0000313|EMBL:AAF51183.1, GN ECO:0000313|FlyBase:FBgn0028970}, Dmel_CG18627 GN {ECO:0000313|EMBL:AAF51183.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF51183.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAD33042.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Canton S {ECO:0000313|EMBL:AAD33042.1}; RA Avedisov S.N., Thomas B.J.; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAF51183.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000313|EMBL:AAL28332.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAL28332.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [5] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [6] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [7] {ECO:0000313|EMBL:AAF51183.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [8] {ECO:0000313|EMBL:AAF51183.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [9] {ECO:0000313|EMBL:AAF51183.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF51183.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF51183.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF51183.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAF51183.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAF51183.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [15] {ECO:0000313|EMBL:AAF51183.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:AAF51183.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from CC geranylgeranyl diphosphate to both cysteines of proteins with the C- CC terminal sequence -XXCC, -XCXC and -CCXX. CC {ECO:0000256|RuleBase:RU365076}. CC -!- CATALYTIC ACTIVITY: CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, CC ChEBI:CHEBI:86021; EC=2.5.1.60; CC Evidence={ECO:0000256|ARBA:ARBA00001577, CC ECO:0000256|RuleBase:RU365076}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|RuleBase:RU365076}; CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU365076}; CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit beta CC family. {ECO:0000256|ARBA:ARBA00010497, ECO:0000256|RuleBase:RU365076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF133269; AAD33042.1; -; mRNA. DR EMBL; AE014134; AAF51183.1; -; Genomic_DNA. DR EMBL; AY060784; AAL28332.1; -; mRNA. DR RefSeq; NP_524894.1; NM_080155.3. DR SMR; Q9XZ68; -. DR IntAct; Q9XZ68; 12. DR STRING; 7227.FBpp0077316; -. DR PaxDb; 7227-FBpp0077316; -. DR DNASU; 47757; -. DR EnsemblMetazoa; FBtr0077631; FBpp0077316; FBgn0028970. DR GeneID; 47757; -. DR KEGG; dme:Dmel_CG18627; -. DR UCSC; CG18627-RA; d. melanogaster. DR AGR; FB:FBgn0028970; -. DR CTD; 5876; -. DR FlyBase; FBgn0028970; RabGGTb. DR VEuPathDB; VectorBase:FBgn0028970; -. DR eggNOG; KOG0366; Eukaryota. DR GeneTree; ENSGT00950000183128; -. DR HOGENOM; CLU_028946_3_0_1; -. DR OMA; VKRCQCP; -. DR OrthoDB; 5478505at2759; -. DR Reactome; R-DME-6803205; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain. DR Reactome; R-DME-8873719; RAB geranylgeranylation. DR BioGRID-ORCS; 47757; 0 hits in 1 CRISPR screen. DR ChiTaRS; betaggt-II; fly. DR GenomeRNAi; 47757; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0028970; Expressed in embryonic/larval hemocyte (Drosophila) and 31 other cell types or tissues. DR GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; IDA:FlyBase. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:UniProtKB-UniRule. DR CDD; cd02894; GGTase-II; 1. DR Gene3D; 1.50.10.20; -; 1. DR InterPro; IPR001330; PFTB_repeat. DR InterPro; IPR045089; PGGT1B-like. DR InterPro; IPR026873; Ptb1. DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase. DR PANTHER; PTHR11774; GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT; 1. DR PANTHER; PTHR11774:SF11; GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA; 1. DR Pfam; PF00432; Prenyltrans; 5. DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|RuleBase:RU365076}; KW Prenyltransferase {ECO:0000256|ARBA:ARBA00022602, KW ECO:0000256|RuleBase:RU365076}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9XZ68}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365076}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU365076}. FT REGION 1..21 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 347 AA; 38542 MW; 7BFC74887548E1B4 CRC64; MDFTTFVKPS NGGGDSGGGG DADGGGQKLQ FWKHVEYIEN HGKQEDDYEY CMTEFLRMSG IYWGTTALDI MGQLERLERK SIIEFVKRCQ CPNTGGFAPC EGHDPHLLYT LSAIQILCTY DALEEIDREA VVRFVVGLQQ PDGSFFGDKW GEVDTRFSFC AVASLTLLGR MEQTIDVEKA VKFVLSCCNQ TDGGFGSKPG AESHAGLIYC CVGFFSLTHR LHLLDVDKLG WWLCERQLPS GGLNGRPEKL PDVCYSWWVL ASLTIMGRLH WISSEKLQQF ILSCQDTETG GFSDRTGNMP DIFHTLFGIG GLSLLGHSGL KAINPTLCMP QYIIDRLGIK PQLLPRP //