ID NRA1_CAEEL Reviewed; 634 AA. AC Q9XUB9; Q8I4F4; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 22-JUL-2015, entry version 100. DE RecName: Full=Nicotinic receptor-associated protein 1; GN Name=nra-1; ORFNames=T28F3.1; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE RP SPLICING. RC STRAIN=Bristol N2; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [2] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=16998478; DOI=10.1038/ncb1476; RA Kubagawa H.M., Watts J.L., Corrigan C., Edmonds J.W., Sztul E., RA Browse J., Miller M.A.; RT "Oocyte signals derived from polyunsaturated fatty acids control sperm RT recruitment in vivo."; RL Nat. Cell Biol. 8:1143-1148(2006). CC -!- FUNCTION: May function in membrane trafficking. Exhibits calcium- CC dependent phospholipid binding properties (By similarity). Affects CC directional sperm motility. {ECO:0000250, CC ECO:0000269|PubMed:16998478}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=a; CC IsoId=Q9XUB9-1; Sequence=Displayed; CC Note=No experimental confirmation available.; CC Name=b; CC IsoId=Q9XUB9-2; Sequence=VSP_039297; CC Note=No experimental confirmation available.; CC -!- DISRUPTION PHENOTYPE: Sperm directional motility defects. CC {ECO:0000269|PubMed:16998478}. CC -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}. CC -!- SIMILARITY: Contains 2 C2 domains. {ECO:0000255|PROSITE- CC ProRule:PRU00041}. CC -!- SIMILARITY: Contains 1 VWFA domain. {ECO:0000255|PROSITE- CC ProRule:PRU00219}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z82285; CAB05302.1; -; Genomic_DNA. DR EMBL; Z82285; CAD56248.1; -; Genomic_DNA. DR PIR; T25425; T25425. DR RefSeq; NP_503069.1; NM_070668.5. [Q9XUB9-1] DR RefSeq; NP_872104.1; NM_182304.3. [Q9XUB9-2] DR UniGene; Cel.17198; -. DR ProteinModelPortal; Q9XUB9; -. DR SMR; Q9XUB9; 178-288. DR IntAct; Q9XUB9; 2. DR MINT; MINT-3383809; -. DR STRING; 6239.T28F3.1a.2; -. DR PaxDb; Q9XUB9; -. DR PRIDE; Q9XUB9; -. DR EnsemblMetazoa; T28F3.1a; T28F3.1a; WBGene00012128. [Q9XUB9-1] DR GeneID; 178508; -. DR KEGG; cel:CELE_T28F3.1; -. DR UCSC; T28F3.1a; c. elegans. [Q9XUB9-1] DR CTD; 178508; -. DR WormBase; T28F3.1a; CE19806; WBGene00012128; nra-1. DR eggNOG; NOG269302; -. DR GeneTree; ENSGT00760000119085; -. DR HOGENOM; HOG000220898; -. DR InParanoid; Q9XUB9; -. DR OMA; DSARYQI; -. DR PhylomeDB; Q9XUB9; -. DR NextBio; 901412; -. DR PRO; PR:Q9XUB9; -. DR Proteomes; UP000001940; Chromosome IV. DR GO; GO:0005886; C:plasma membrane; IDA:WormBase. DR GO; GO:0097120; P:receptor localization to synapse; IMP:WormBase. DR Gene3D; 2.60.40.150; -; 2. DR InterPro; IPR000008; C2_dom. DR InterPro; IPR010734; Copine. DR InterPro; IPR002035; VWF_A. DR Pfam; PF00168; C2; 2. DR Pfam; PF07002; Copine; 1. DR SMART; SM00239; C2; 2. DR SMART; SM00327; VWA; 1. DR SUPFAM; SSF49562; SSF49562; 2. DR SUPFAM; SSF53300; SSF53300; 1. DR PROSITE; PS50004; C2; 1. DR PROSITE; PS50234; VWFA; 1. PE 3: Inferred from homology; KW Alternative splicing; Complete proteome; Reference proteome; Repeat. FT CHAIN 1 634 Nicotinic receptor-associated protein 1. FT /FTId=PRO_0000144851. FT DOMAIN 21 125 C2 1. {ECO:0000255|PROSITE- FT ProRule:PRU00041}. FT DOMAIN 182 197 C2 2. {ECO:0000255|PROSITE- FT ProRule:PRU00041}. FT DOMAIN 338 557 VWFA. {ECO:0000255|PROSITE- FT ProRule:PRU00219}. FT VAR_SEQ 258 269 Missing (in isoform b). {ECO:0000305}. FT /FTId=VSP_039297. SQ SEQUENCE 634 AA; 71101 MW; 9CF95130F9A2DCCE CRC64; MNQPIGIADS SRPKTNVRLT ISANNLMDLD VFSKSDPICL IYEKTSGRKA TTTEEITVPT WKDKQWTERG RTEVVMNNLN PQFTKTFLLP YFFEETQLLR FEIYDADSPT VGQDLSSHDF LGRFECVLAQ IVSYSTLKAH LGKTGQIGAQ WRNKDKNTKT GSITIYAEED EKAEKIQFDV CGEGLDKKDF FGKSDPYLNF KRKFDDGSTH LIHRTEVKPK TLDPRWATVQ INTQTLCAKD GDRPIIIECY DHDKWKKGEE PRGDAKFSRD DLIGTAQTTL NELLRGSSDA VEILLTNEKK KAKKGDKYKC SGTLKIWNSR IVIEPTFLDF ISGGTQLDFA VAVDFTASNG PPKSSSSLHF MSADRPNQYE LALRSVLSIC QHYNSSKTFE AFGFGAKLPN QSSVSAIFPL DLQRGTSEVV GITGVMTAYR HALSNVQLYG PTNFAPIIEN VARKAQNMIH DSARYQILLI ITDGIISDMH ATIRSIISAS GLPLSIIIIG VGNEDFEKMH ELDSDDALLQ QDSRIAQRDI VQFVTMREFL NNGQGLYLDP DVIQENLARE VLYEVPAQLT GYMKQRGFQP RPVDDPWRRD SPPPEFDPIL DGTGRRAPML QAPPAGFQYP VYADTSIASA PPMY //