ID MPEG1_RAT Reviewed; 714 AA. AC Q9WV57; DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot. DT 18-MAR-2008, sequence version 2. DT 20-JAN-2009, entry version 27. DE RecName: Full=Macrophage-expressed gene 1 protein; DE Short=Macrophage gene 1 protein; DE Short=Mpg-1; DE Flags: Precursor; GN Name=Mpeg1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway; RX PubMed=15057822; DOI=10.1038/nature02426; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-708. RC STRAIN=Sprague-Dawley; RA Chen S., Garcia G.E., Xia Y., Wilson C.B., Ku G., Feng L.; RT "Immunoneutralization of the macrophage gene-1 product attenuates RT renal injury in experimental glomerulonephritis in WKY rats."; RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein (Potential). CC -!- SIMILARITY: Contains 1 MACPF domain. CC -!- SEQUENCE CAUTION: CC Sequence=AAD38417.1; Type=Frameshift; Positions=Several; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABR03005343; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF156540; AAD38417.1; ALT_FRAME; mRNA. DR RefSeq; NP_072139.1; -. DR UniGene; Rn.162497; -. DR GeneID; 64552; -. DR KEGG; rno:64552; -. DR RGD; 69275; Mpeg1. DR HOVERGEN; Q9WV57; -. DR NextBio; 613448; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR InterPro; IPR001862; MAC_perforin. DR Pfam; PF01823; MACPF; 1. DR SMART; SM00457; MACPF; 1. DR PROSITE; PS00279; MACPF_1; FALSE_NEG. DR PROSITE; PS51412; MACPF_2; 1. PE 2: Evidence at transcript level; KW Glycoprotein; Membrane; Signal; Transmembrane. FT SIGNAL 1 19 Potential. FT CHAIN 20 714 Macrophage-expressed gene 1 protein. FT /FTId=PRO_0000324145. FT TOPO_DOM 20 653 Extracellular (Potential). FT TRANSMEM 654 674 Potential. FT TOPO_DOM 675 714 Cytoplasmic (Potential). FT DOMAIN 30 345 MACPF. FT CARBOHYD 185 185 N-linked (GlcNAc...) (Potential). FT CARBOHYD 269 269 N-linked (GlcNAc...) (Potential). FT CARBOHYD 375 375 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 714 AA; 78527 MW; 3235512C40B9DF35 CRC64; MNSFMAIALI WMMIACAEAD KPLRDPGMTG FQTCKDTLKL PVLEVLPGGG WDNLRNIDMG RVIDLTYTNC KTTEDGQYII PDEVYTIPQK ESNLEMNSEI RDSWVNYQST TSFSINTELS LFSKVNGKFS TEFQRMKTLQ VKDQAVTTRV QVRNRIYTVK NSPTSELSFG FTNALMDICD QLEKNQTKMA TYLAELLVLN YGTHVITSVD AGAALVQEDH IRSSFLLDNQ NSENTVTASA GIAFLNIVNF KVETDHTSQT LLTKSYLSNR TNSRVQSFGG IPFYPGITLE TWQKGITNHL VAIDRAGLPL HFFIKPDKLP GLPGGLVKKL SKTVETAVRH YYTFNTHPGC TNVDSPNFNF QANMEDDSCD AKVTNFTFGG LYQECTELSG DALCQNLEQK NLLTGDFSCP SGYTPVHLLS QTHEEGYSRL ECKKKCTLKI FCKTVCEDVF RVAKAQFRAY WCVATGQVPD NSGLLFGGLF TDKSINPMTN AQSCPAGYIP LNLFESLKVC VSLDYELGYK FSVPFGGFFS CIMGNPLVNS DTAKDIGAPS LKKCPGGFSQ HLAVISDGCQ VSYCVKAGIF TGGSLLPVRL PPYTKPPLMS QVATNTVIVT SSETARSWIK DPQTNQWKLG EPLELHKAMT VIHGDGNGMS GGEAAGVTLG VIIALGIVIT LAIYSTRKYK KEKEYQEIEE QESLVGSFAT DASPPNGEQD PCPA //