ID Q9W4H9_DROME Unreviewed; 478 AA. AC Q9W4H9; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 22-FEB-2023, entry version 200. DE RecName: Full=WD repeat-containing protein 55 homolog {ECO:0000256|ARBA:ARBA00023478}; GN Name=fzr {ECO:0000313|EMBL:AAF45973.1, GN ECO:0000313|FlyBase:FBgn0262699}; GN Synonyms=anon-WO03040301.193 {ECO:0000313|EMBL:AAF45973.1}, GN APC/C[Fzr/Cdh1] {ECO:0000313|EMBL:AAF45973.1}, CDH1 GN {ECO:0000313|EMBL:AAF45973.1}, Cdh1 {ECO:0000313|EMBL:AAF45973.1}, GN cdh1 {ECO:0000313|EMBL:AAF45973.1}, Cdh1/Fzr GN {ECO:0000313|EMBL:AAF45973.1}, Cdh1[Fzr] GN {ECO:0000313|EMBL:AAF45973.1}, Cdh1FZR {ECO:0000313|EMBL:AAF45973.1}, GN Cdh[Fzr] {ECO:0000313|EMBL:AAF45973.1}, dFZR GN {ECO:0000313|EMBL:AAF45973.1}, Dmel\CG3000 GN {ECO:0000313|EMBL:AAF45973.1}, Fxr {ECO:0000313|EMBL:AAF45973.1}, Fzr GN {ECO:0000313|EMBL:AAF45973.1}, fzr/Cdh1 {ECO:0000313|EMBL:AAF45973.1}, GN fzr/cdh1 {ECO:0000313|EMBL:AAF45973.1}, Fzr/rap GN {ECO:0000313|EMBL:AAF45973.1}, Hec/Cdh[Fzr] GN {ECO:0000313|EMBL:AAF45973.1}, l(1)G0326 GN {ECO:0000313|EMBL:AAF45973.1}, l(1)G0418 GN {ECO:0000313|EMBL:AAF45973.1}, rap {ECO:0000313|EMBL:AAF45973.1}, GN rap/fizzy-related {ECO:0000313|EMBL:AAF45973.1}, Rap/Fzr GN {ECO:0000313|EMBL:AAF45973.1}, rap/Fzr {ECO:0000313|EMBL:AAF45973.1}, GN rap/fzr {ECO:0000313|EMBL:AAF45973.1}, redax GN {ECO:0000313|EMBL:AAF45973.1}, wex {ECO:0000313|EMBL:AAF45973.1}; GN ORFNames=CG3000 {ECO:0000313|EMBL:AAN09125.1, GN ECO:0000313|FlyBase:FBgn0262699}, Dmel_CG3000 GN {ECO:0000313|EMBL:AAF45973.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAN71158.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAN71158.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A., RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [14] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. CC {ECO:0000256|ARBA:ARBA00006445}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AAF45973.1; -; Genomic_DNA. DR EMBL; AE014298; AAN09125.1; -; Genomic_DNA. DR EMBL; BT001403; AAN71158.1; -; mRNA. DR EMBL; BT010011; AAQ22480.1; -; mRNA. DR RefSeq; NP_524852.2; NM_080113.3. DR RefSeq; NP_726941.1; NM_167013.2. DR AlphaFoldDB; Q9W4H9; -. DR SMR; Q9W4H9; -. DR ComplexPortal; CPX-2728; Anaphase-promoting complex. DR IntAct; Q9W4H9; 1. DR STRING; 7227.FBpp0070654; -. DR DNASU; 45922; -. DR EnsemblMetazoa; FBtr0070686; FBpp0070654; FBgn0262699. DR EnsemblMetazoa; FBtr0070687; FBpp0070655; FBgn0262699. DR GeneID; 45922; -. DR KEGG; dme:Dmel_CG3000; -. DR UCSC; CG3000-RA; d. melanogaster. DR AGR; FB:FBgn0262699; -. DR CTD; 45922; -. DR FlyBase; FBgn0262699; fzr. DR VEuPathDB; VectorBase:FBgn0262699; -. DR eggNOG; KOG0305; Eukaryota. DR GeneTree; ENSGT00950000183104; -. DR HOGENOM; CLU_014831_4_2_1; -. DR OMA; MDQDYES; -. DR OrthoDB; 20041at2759; -. DR Reactome; R-DME-174084; Autodegradation of Cdh1 by Cdh1:APC/C. DR Reactome; R-DME-174113; SCF-beta-TrCP mediated degradation of Emi1. DR Reactome; R-DME-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1. DR Reactome; R-DME-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. DR Reactome; R-DME-176408; Regulation of APC/C activators between G1/S and early anaphase. DR Reactome; R-DME-176417; Phosphorylation of Emi1. DR Reactome; R-DME-2559582; Senescence-Associated Secretory Phenotype (SASP). DR Reactome; R-DME-68867; Assembly of the pre-replicative complex. DR Reactome; R-DME-69017; CDK-mediated phosphorylation and removal of Cdc6. DR Reactome; R-DME-69656; Cyclin A:Cdk2-associated events at S phase entry. DR Reactome; R-DME-983168; Antigen processing: Ubiquitination & Proteasome degradation. DR BioGRID-ORCS; 45922; 0 hits in 1 CRISPR screen. DR ChiTaRS; Fmr1; fly. DR GenomeRNAi; 45922; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0262699; Expressed in cleaving embryo and 32 other tissues. DR GO; GO:0005680; C:anaphase-promoting complex; IDA:FlyBase. DR GO; GO:0030424; C:axon; IDA:FlyBase. DR GO; GO:0005814; C:centriole; IDA:FlyBase. DR GO; GO:0005813; C:centrosome; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005819; C:spindle; IDA:FlyBase. DR GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central. DR GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central. DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IDA:FlyBase. DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase. DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase. DR GO; GO:0010001; P:glial cell differentiation; IDA:FlyBase. DR GO; GO:0008347; P:glial cell migration; IMP:FlyBase. DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central. DR GO; GO:0031536; P:positive regulation of exit from mitosis; IMP:FlyBase. DR GO; GO:0030163; P:protein catabolic process; IDA:FlyBase. DR GO; GO:0007088; P:regulation of mitotic nuclear division; IMP:FlyBase. DR CDD; cd00200; WD40; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1. DR InterPro; IPR024977; Apc4_WD40_dom. DR InterPro; IPR033010; Cdc20/Fizzy. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1. DR PANTHER; PTHR19918:SF1; FIZZY-RELATED PROTEIN HOMOLOG; 1. DR Pfam; PF12894; ANAPC4_WD40; 1. DR Pfam; PF00400; WD40; 3. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; WD40 repeat-like; 1. DR PROSITE; PS00678; WD_REPEATS_1; 1. DR PROSITE; PS50082; WD_REPEATS_2; 3. DR PROSITE; PS50294; WD_REPEATS_REGION; 3. PE 2: Evidence at transcript level; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE- KW ProRule:PRU00221}. FT REPEAT 210..251 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT DOMAIN 213..266 FT /note="Anaphase-promoting complex subunit 4 WD40" FT /evidence="ECO:0000259|Pfam:PF12894" FT REPEAT 294..335 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT REPEAT 424..465 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" SQ SEQUENCE 478 AA; 53508 MW; 0E6098740897CF76 CRC64; MFSPEYEKRI LKHYSPVARN LFNNFESSTT PTSLDRFIPC RAYNNWQTNF ASINKSNDNS PQTSKKQRDC GETARDSLAY SCLLKNELLG SAIDDVKTAG EERNENAYTP AAKRSLFKYQ SPTKQDYNGE CPYSLSPVSA KSQKLLRSPR KATRKISRIP FKVLDAPELQ DDFYLNLVDW SSQNVLAVGL GSCVYLWSAC TSQVTRLCDL SPDANTVTSV SWNERGNTVA VGTHHGYVTV WDVAANKQIN KLNGHSARVG ALAWNSDILS SGSRDRWIIQ RDTRTPQLQS ERRLAGHRQE VCGLKWSPDN QYLASGGNDN RLYVWNQHSV NPVQSYTEHM AAVKAIAWSP HHHGLLASGG GTADRCIRFW NTLTGQPMQC VDTGSQVCNL AWSKHSSELV STHGYSQNQI LVWKYPSLTQ VAKLTGHSYR VLYLALSPDG EAIVTGAGDE TLRFWNVFSK ARSQKENKSV LNLFANIR //