ID Q9W4H9_DROME Unreviewed; 478 AA. AC Q9W4H9; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 05-JUN-2019, entry version 179. DE SubName: Full=Fizzy-related, isoform A {ECO:0000313|EMBL:AAF45973.1}; DE SubName: Full=Fizzy-related, isoform B {ECO:0000313|EMBL:AAN09125.1}; DE SubName: Full=GH07620p {ECO:0000313|EMBL:AAN71158.1}; DE SubName: Full=RE20929p {ECO:0000313|EMBL:AAQ22480.1}; GN Name=fzr {ECO:0000313|EMBL:AAF45973.1, GN ECO:0000313|FlyBase:FBgn0262699}; GN Synonyms=anon-WO03040301.193 {ECO:0000313|EMBL:AAF45973.1}, APC GN {ECO:0000313|EMBL:AAF45973.1}, C[Fzr {ECO:0000313|EMBL:AAF45973.1}, GN CDH1 {ECO:0000313|EMBL:AAF45973.1}, Cdh1 GN {ECO:0000313|EMBL:AAF45973.1}, cdh1 {ECO:0000313|EMBL:AAF45973.1}, GN Cdh1[Fzr] {ECO:0000313|EMBL:AAF45973.1}, Cdh1] GN {ECO:0000313|EMBL:AAF45973.1}, Cdh[Fzr] {ECO:0000313|EMBL:AAF45973.1}, GN dFZR {ECO:0000313|EMBL:AAF45973.1}, Dmel\CG3000 GN {ECO:0000313|EMBL:AAF45973.1}, fizzy-related GN {ECO:0000313|EMBL:AAF45973.1}, Fxr {ECO:0000313|EMBL:AAF45973.1}, Fzr GN {ECO:0000313|EMBL:AAF45973.1}, Hec {ECO:0000313|EMBL:AAF45973.1}, GN l(1)G0326 {ECO:0000313|EMBL:AAF45973.1}, l(1)G0418 GN {ECO:0000313|EMBL:AAF45973.1}, Rap {ECO:0000313|EMBL:AAF45973.1}, rap GN {ECO:0000313|EMBL:AAF45973.1}, redax {ECO:0000313|EMBL:AAF45973.1}, GN wex {ECO:0000313|EMBL:AAF45973.1}; GN ORFNames=CG3000 {ECO:0000313|EMBL:AAN09125.1, GN ECO:0000313|FlyBase:FBgn0262699}, Dmel_CG3000 GN {ECO:0000313|EMBL:AAF45973.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAN71158.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAN71158.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAQ22480.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAQ22480.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [9] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAN09125.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RA O'Boyle S.T.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [13] {ECO:0000313|EMBL:AAF45973.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [14] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=10.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [15] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=10.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [16] {ECO:0000313|EMBL:AAF45973.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AAF45973.1; -; Genomic_DNA. DR EMBL; AE014298; AAN09125.1; -; Genomic_DNA. DR EMBL; BT001403; AAN71158.1; -; mRNA. DR EMBL; BT010011; AAQ22480.1; -; mRNA. DR RefSeq; NP_524852.2; NM_080113.3. DR RefSeq; NP_726941.1; NM_167013.2. DR IntAct; Q9W4H9; 1. DR STRING; 7227.FBpp0070654; -. DR PRIDE; Q9W4H9; -. DR EnsemblMetazoa; FBtr0070686; FBpp0070654; FBgn0262699. DR EnsemblMetazoa; FBtr0070687; FBpp0070655; FBgn0262699. DR GeneID; 45922; -. DR KEGG; dme:Dmel_CG3000; -. DR UCSC; CG3000-RA; d. melanogaster. DR CTD; 45922; -. DR FlyBase; FBgn0262699; fzr. DR eggNOG; KOG0305; Eukaryota. DR eggNOG; ENOG410XQ8I; LUCA. DR GeneTree; ENSGT00950000183104; -. DR KO; K03364; -. DR OMA; SVCSVQW; -. DR OrthoDB; 1220675at2759; -. DR Reactome; R-DME-174084; Autodegradation of Cdh1 by Cdh1:APC/C. DR Reactome; R-DME-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1. DR Reactome; R-DME-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. DR Reactome; R-DME-176408; Regulation of APC/C activators between G1/S and early anaphase. DR Reactome; R-DME-176417; Phosphorylation of Emi1. DR Reactome; R-DME-2559582; Senescence-Associated Secretory Phenotype (SASP). DR Reactome; R-DME-69017; CDK-mediated phosphorylation and removal of Cdc6. DR Reactome; R-DME-983168; Antigen processing: Ubiquitination & Proteasome degradation. DR ChiTaRS; Fmr1; fly. DR GenomeRNAi; 45922; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0262699; Expressed in 35 organ(s), highest expression level in embryo. DR GO; GO:0005680; C:anaphase-promoting complex; IDA:FlyBase. DR GO; GO:0030424; C:axon; IDA:FlyBase. DR GO; GO:0005814; C:centriole; IDA:FlyBase. DR GO; GO:0005813; C:centrosome; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005819; C:spindle; IDA:FlyBase. DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:FlyBase. DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro. DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IDA:FlyBase. DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase. DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase. DR GO; GO:0010001; P:glial cell differentiation; IDA:FlyBase. DR GO; GO:0008347; P:glial cell migration; IMP:FlyBase. DR GO; GO:0031536; P:positive regulation of exit from mitosis; IMP:FlyBase. DR GO; GO:1904668; P:positive regulation of ubiquitin protein ligase activity; IEA:InterPro. DR GO; GO:0030163; P:protein catabolic process; IDA:FlyBase. DR GO; GO:0007088; P:regulation of mitotic nuclear division; IMP:FlyBase. DR Gene3D; 2.130.10.10; -; 1. DR InterPro; IPR024977; Apc4_WD40_dom. DR InterPro; IPR033010; Cdc20/Fizzy. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR017986; WD40_repeat_dom. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR PANTHER; PTHR19918; PTHR19918; 1. DR Pfam; PF12894; ANAPC4_WD40; 1. DR Pfam; PF00400; WD40; 3. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; SSF50978; 1. DR PROSITE; PS00678; WD_REPEATS_1; 2. DR PROSITE; PS50082; WD_REPEATS_2; 3. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|SAAS:SAAS00723881}; KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221, KW ECO:0000256|SAAS:SAAS00723873}. FT DOMAIN 210 465 WD_REPEATS_REGION. {ECO:0000259|PROSITE: FT PS50294}. FT REPEAT 210 251 WD. {ECO:0000256|PROSITE-ProRule: FT PRU00221}. FT REPEAT 294 335 WD. {ECO:0000256|PROSITE-ProRule: FT PRU00221}. FT REPEAT 424 465 WD. {ECO:0000256|PROSITE-ProRule: FT PRU00221}. SQ SEQUENCE 478 AA; 53508 MW; 0E6098740897CF76 CRC64; MFSPEYEKRI LKHYSPVARN LFNNFESSTT PTSLDRFIPC RAYNNWQTNF ASINKSNDNS PQTSKKQRDC GETARDSLAY SCLLKNELLG SAIDDVKTAG EERNENAYTP AAKRSLFKYQ SPTKQDYNGE CPYSLSPVSA KSQKLLRSPR KATRKISRIP FKVLDAPELQ DDFYLNLVDW SSQNVLAVGL GSCVYLWSAC TSQVTRLCDL SPDANTVTSV SWNERGNTVA VGTHHGYVTV WDVAANKQIN KLNGHSARVG ALAWNSDILS SGSRDRWIIQ RDTRTPQLQS ERRLAGHRQE VCGLKWSPDN QYLASGGNDN RLYVWNQHSV NPVQSYTEHM AAVKAIAWSP HHHGLLASGG GTADRCIRFW NTLTGQPMQC VDTGSQVCNL AWSKHSSELV STHGYSQNQI LVWKYPSLTQ VAKLTGHSYR VLYLALSPDG EAIVTGAGDE TLRFWNVFSK ARSQKENKSV LNLFANIR //