ID Q9VSQ0_DROME Unreviewed; 1294 AA. AC Q9VSQ0; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 2. DT 08-NOV-2023, entry version 184. DE SubName: Full=FI03664p {ECO:0000313|EMBL:ACJ13163.1}; DE SubName: Full=Formin homology 2 domain containing, isoform B {ECO:0000313|EMBL:AAF50366.2}; GN Name=Fhos {ECO:0000313|EMBL:AAF50366.2, GN ECO:0000313|FlyBase:FBgn0266084}; GN Synonyms=CG32025 {ECO:0000313|EMBL:AAF50366.2}, CG32030 GN {ECO:0000313|EMBL:AAF50366.2}, CG5775 {ECO:0000313|EMBL:AAF50366.2}, GN CG5797 {ECO:0000313|EMBL:AAF50366.2}, desert GN {ECO:0000313|EMBL:AAF50366.2}, dFHOS {ECO:0000313|EMBL:AAF50366.2}, GN Dmel\CG42610 {ECO:0000313|EMBL:AAF50366.2}, fhos GN {ECO:0000313|EMBL:AAF50366.2}, Fhos-RB {ECO:0000313|EMBL:ACJ13163.1}, GN jaz {ECO:0000313|EMBL:AAF50366.2}, knit {ECO:0000313|EMBL:AAF50366.2}, GN l(3)01629 {ECO:0000313|EMBL:AAF50366.2}; GN ORFNames=CG42610 {ECO:0000313|EMBL:AAF50366.2, GN ECO:0000313|FlyBase:FBgn0266084}, Dmel_CG42610 GN {ECO:0000313|EMBL:AAF50366.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF50366.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF50366.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF50366.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF50366.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF50366.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF50366.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [9] {ECO:0000313|EMBL:AAF50366.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [10] {ECO:0000313|EMBL:ACJ13163.1} RP NUCLEOTIDE SEQUENCE. RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AAF50366.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AAF50366.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AAF50366.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [14] {ECO:0000313|EMBL:AAF50366.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AAF50366.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014296; AAF50366.2; -; Genomic_DNA. DR EMBL; BT050456; ACJ13163.1; -; mRNA. DR RefSeq; NP_729411.1; NM_168294.3. DR SMR; Q9VSQ0; -. DR EnsemblMetazoa; FBtr0302086; FBpp0291296; FBgn0266084. DR GeneID; 39004; -. DR UCSC; CG32030-RB; d. melanogaster. DR AGR; FB:FBgn0266084; -. DR CTD; 39004; -. DR FlyBase; FBgn0266084; Fhos. DR VEuPathDB; VectorBase:FBgn0266084; -. DR OrthoDB; 2918313at2759; -. DR BioGRID-ORCS; 39004; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 39004; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0266084; Expressed in oviduct (Drosophila) and 36 other tissues. DR ExpressionAtlas; Q9VSQ0; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase. DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central. DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:FlyBase. DR GO; GO:0003012; P:muscle system process; IGI:FlyBase. DR GO; GO:0030335; P:positive regulation of cell migration; IMP:FlyBase. DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:FlyBase. DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:FlyBase. DR GO; GO:0010623; P:programmed cell death involved in cell development; IMP:FlyBase. DR GO; GO:0035070; P:salivary gland histolysis; IMP:FlyBase. DR GO; GO:0060439; P:trachea morphogenesis; IMP:FlyBase. DR GO; GO:0044319; P:wound healing, spreading of cells; IMP:FlyBase. DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1. DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR015425; FH2_Formin. DR InterPro; IPR042201; FH2_Formin_sf. DR InterPro; IPR041387; FHOD1_GBD_N. DR InterPro; IPR014768; GBD/FH3_dom. DR PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1. DR PANTHER; PTHR45920:SF4; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1. DR Pfam; PF02181; FH2; 1. DR Pfam; PF18382; Formin_GBD_N; 1. DR SMART; SM00498; FH2; 1. DR SUPFAM; SSF48371; ARM repeat; 1. DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1. DR PROSITE; PS51444; FH2; 1. DR PROSITE; PS51232; GBD_FH3; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 56..419 FT /note="GBD/FH3" FT /evidence="ECO:0000259|PROSITE:PS51232" FT DOMAIN 883..1274 FT /note="FH2" FT /evidence="ECO:0000259|PROSITE:PS51444" FT REGION 335..378 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 391..431 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 624..709 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 757..788 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 566..593 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 338..353 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 354..369 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 391..410 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 636..677 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 682..696 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 759..788 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1294 AA; 144453 MW; 95A8F22560081B26 CRC64; MIVKMEPDEL ITFRVQYLVD SDPLSACTAF PIPVRAPTYA FATTMPLANQ LGTILRLLNA PQSIDDAAIQ VYKDGDYGAY LDLESSLAEQ AEEIEGVNVS RKNSLVVRTQ LNVRVQAIIE KLLSAQGSDL RRALFSLKQV FQEDKDLVHA FVALGGLNCL VRVGNCADQN YQNYILRALG QVMLYVDGMN GVMKHEPTMQ WLYSLIASNY RSVVKTALKL LLVFVEYAES NCYVLVSAIH AVDASQGTLP WSNIMRLLKD YDNADAELVI YATSLINKTL AGLNDQDSFY DESDLLEQQG METVIQRYMS KPGTDLDLLD QLQLYEAVLK FEDGESDGQR LPQNSMRKTQ RYRPGANTTE RRKSRRHSTD NSPASLTKVL PTTVLRMTPT QATVDEDSSG STNSTEFSGG LFNEKKPRDG AGVTPGLRRR RERAERHKSF LKEQQEAAAN GIFAALEQRE GLGQIVTAIP ATIQTGDSPP QSLQHEVPPC NNISGITNIS NNNVSNLSCN DTPNNSLLVM SPSKQLLTGS HSISIINNSF DKASNNNQSE FLTKKNLFRE RNSTVINGIM KNIQQTDSAY KKYENEANRL NNYYSQSPKH QIHQPIQPTP EVLLSPKKTL NASGFDFTPA PLSSTPVKCD VPPEPEPLSP VKKPAAAPPP PPPPPPPPPP PPGWWHAPIY NSPQARTLTS TNPELLPHPV DPSDMESEDQ QLLLQLKRDH TVKDLTQKLS NLPMSPTQDS ANRALVGDMS GLISKAKEGL AKSKSKGEIS RSSSVDQDVK KSEPKKSENE LHWEELVRNM TRPLNLCDLD FTDLRDDDEK DVLAPRSLGA GIPPPPPPLG GAIAPPPMMP PSLAPPPMYG YGGSLTNSVN SLNGSINGEL VNGNNTIKKN KKTVKLFWKE VREDMIPQVV GKTIWDELPD ANVDTQKLEH LFESRAKDLM TKKQQELNKS KEIIVLDHKR SNAINIAITK LPPPRAIKTA ILKMDATVVT REGIDKLLNM LPTDEERGKI QEAQLSNPEL PLGSAEQFLL TLASISELEA RLKLWAFRLD FDNSEKEIAE PLMDLKQGIE ILRQNRTFRS ILSTLLSVGI FLNGAPVKGF QIEYLAKVPE VKDTVHKHSL LHHLCHMVME SSSDTSDLYS EIGPITRASK ADFTDLAHNL NQLEAECKAC WDRLKLIAKH DCPPPLKQKL VDFLADCAER IIILQIVHRR VMNRYRKFLL WLGMPQHSVA ESRPNEFCRT LSEFALEYRT TRERVQQQLE KKANHRERNK TRGKLIIDMA KFKTKDDVAD DELK //