ID Q9VSM9_DROME Unreviewed; 662 AA. AC Q9VSM9; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 07-APR-2021, entry version 183. DE RecName: Full=Cell division control protein {ECO:0000256|PIRNR:PIRNR001767}; GN Name=Cdc6 {ECO:0000313|EMBL:AAF50387.1, GN ECO:0000313|FlyBase:FBgn0035918}; GN Synonyms=CDC6 {ECO:0000313|EMBL:AAF50387.1}, cdc6 GN {ECO:0000313|EMBL:AAF50387.1}, DmCdc6 {ECO:0000313|EMBL:AAF50387.1}, GN Dmel\CG5971 {ECO:0000313|EMBL:AAF50387.1}; GN ORFNames=CG5971 {ECO:0000313|EMBL:AAF50387.1, GN ECO:0000313|FlyBase:FBgn0035918}, Dmel_CG5971 GN {ECO:0000313|EMBL:AAF50387.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAK93146.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAK93146.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [6] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:ABI34852.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=0 {ECO:0000313|EMBL:ABI34852.1}, 2 RC {ECO:0000313|EMBL:ABI34853.1}, and 3 {ECO:0000313|EMBL:ABI34854.1}; RA Wiggins B.L., Malik H.S.; RT "Positive selection of Drosophila cdc6, an essential DNA replication- RT licensing gene, suggests an adaptive choice of replication origins."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [12] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [13] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [14] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [15] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [16] {ECO:0007829|PDB:7JGR, ECO:0007829|PDB:7JGS, ECO:0007829|PDB:7JK2} RP STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 242-662. RX PubMed=32848132; DOI=10.1038/s41467-020-18067-7; RA Schmidt J.M., Bleichert F.; RT "Structural mechanism for replication origin binding and remodeling by a RT metazoan origin recognition complex and its co-loader Cdc6."; RL Nat. Commun. 11:4263-4263(2020). RN [17] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the initiation of DNA replication. Also CC participates in checkpoint controls that ensure DNA replication is CC completed before mitosis is initiated. {ECO:0000256|PIRNR:PIRNR001767}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001767}. CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. CC {ECO:0000256|ARBA:ARBA00006184, ECO:0000256|PIRNR:PIRNR001767}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014296; AAF50387.1; -; Genomic_DNA. DR EMBL; AY051722; AAK93146.1; -; mRNA. DR EMBL; DQ839683; ABI34852.1; -; Genomic_DNA. DR EMBL; DQ839684; ABI34853.1; -; Genomic_DNA. DR EMBL; DQ839685; ABI34854.1; -; Genomic_DNA. DR RefSeq; NP_648247.1; NM_139990.3. DR PDB; 7JGR; EM; 3.90 A; G=242-662. DR PDB; 7JGS; EM; 3.20 A; G=242-662. DR PDB; 7JK2; EM; 3.20 A; G=242-662. DR PDB; 7JK3; EM; 3.40 A; G=242-662. DR PDB; 7JK4; EM; 3.40 A; G=242-662. DR SMR; Q9VSM9; -. DR IntAct; Q9VSM9; 1. DR STRING; 7227.FBpp0076371; -. DR PRIDE; Q9VSM9; -. DR DNASU; 38989; -. DR EnsemblMetazoa; FBtr0076647; FBpp0076371; FBgn0035918. DR GeneID; 38989; -. DR KEGG; dme:Dmel_CG5971; -. DR UCSC; CG5971-RA; d. melanogaster. DR CTD; 990; -. DR FlyBase; FBgn0035918; Cdc6. DR eggNOG; KOG2227; Eukaryota. DR GeneTree; ENSGT00530000063498; -. DR HOGENOM; CLU_012774_3_1_1; -. DR OMA; ERDHMEA; -. DR OrthoDB; 935804at2759; -. DR Reactome; R-DME-176187; Activation of ATR in response to replication stress. DR Reactome; R-DME-68689; CDC6 association with the ORC:origin complex. DR Reactome; R-DME-68827; CDT1 association with the CDC6:ORC:origin complex. DR Reactome; R-DME-68867; Assembly of the pre-replicative complex. DR Reactome; R-DME-68949; Orc1 removal from chromatin. DR Reactome; R-DME-68962; Activation of the pre-replicative complex. DR Reactome; R-DME-69017; CDK-mediated phosphorylation and removal of Cdc6. DR BioGRID-ORCS; 38989; 1 hit in 1 CRISPR screen. DR GenomeRNAi; 38989; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0035918; Expressed in embryo and 40 other tissues. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule. DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule. DR GO; GO:0033314; P:mitotic DNA replication checkpoint; IBA:GO_Central. DR CDD; cd08768; Cdc6_C; 1. DR Gene3D; 1.10.10.10; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR016314; Cdc6/18. DR InterPro; IPR015163; Cdc6_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF13401; AAA_22; 1. DR Pfam; PF09079; Cdc6_C; 1. DR PIRSF; PIRSF001767; Cdc6; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM01074; Cdc6_C; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:7JGR, ECO:0007829|PDB:7JGS, KW ECO:0007829|PDB:7JK2, ECO:0007829|PDB:7JK3}; KW DNA replication {ECO:0000256|ARBA:ARBA00022705}; KW Nucleus {ECO:0000256|PIRNR:PIRNR001767}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9VSM9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 289..434 FT /note="AAA" FT /evidence="ECO:0000259|SMART:SM00382" FT DOMAIN 564..644 FT /note="Cdc6_C" FT /evidence="ECO:0000259|SMART:SM01074" FT REGION 1..250 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 7..30 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 31..49 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 84..109 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 110..142 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 164..210 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 211..250 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 662 AA; 75135 MW; 7EC3E0655FA8BCB0 CRC64; MAAVRRSTRL SSISKATAAS PLPPSTQTPR RSEVWKRRQP KKVLADSDEE EEVVTAIYDL TSPVSENNEN RNVLNKMDKI SRRRTSQVQV AQSELPKTPR STKKTVQSAG SSRAKREEEN REATARFLEG EQDSEVDPLH GSPPKQRKLQ PLPQHLISPS RLLDRLSIDE RQEEEVEATT HKTETAEQQP KHQAKDEAKP RPKQQEDPLA QKQQEKPPTK QPNKNQTKEK SNIQTNEETQ QNNLPSPSRN KYQNARRVLN SAETQNLPGR ESQLQELREF FSNHLESQTS GSLYVSGQPG TGKTACLSLL LRDPDFSKRL QRVYINCTSI ASVGAVYKKL CTELQLKVSG RTERDHLEAI QRHLKTAKRM LLLVLDEIDQ LCTSRQEVLY TIFEWPALPG SRILLVGIAN SLDLTDRALM RLNARCELKP RLMHFPPYSK QQIVEIFKSR LAEAEVLDVF PPVTLQLLAA KVSAISGDVR RALDIGRRVV EIAEQQKRDG EKEFNMKALQ LEGKDAVEAK EKQDTLKPVQ VTQVAAVLNK VYGASQNLEE DIEASFPLQQ KLMLCTLVLM LRNERNKDIS MGRLHEVYRR VCAKRNILAL DQAEFTGTVD LVETRGILRI MRKKEPRLHK VLLQWDEEEV HAALSDKQLI ASILSDTACL SK //