ID Q9VSM9_DROME Unreviewed; 662 AA. AC Q9VSM9; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 27-SEP-2017, entry version 152. DE SubName: Full=Cdc6 {ECO:0000313|EMBL:AAF50387.1}; DE SubName: Full=LD25083p {ECO:0000313|EMBL:AAK93146.1}; GN Name=Cdc6 {ECO:0000313|EMBL:AAF50387.1, GN ECO:0000313|FlyBase:FBgn0035918}; GN Synonyms=CDC6 {ECO:0000313|EMBL:AAF50387.1}, cdc6 GN {ECO:0000313|EMBL:AAF50387.1}, DmCdc6 {ECO:0000313|EMBL:AAF50387.1}, GN Dmel\CG5971 {ECO:0000313|EMBL:AAF50387.1}; GN ORFNames=CG5971 {ECO:0000313|EMBL:AAF50387.1, GN ECO:0000313|FlyBase:FBgn0035918}, Dmel_CG5971 GN {ECO:0000313|EMBL:AAF50387.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAK93146.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAK93146.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., RA Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., RA Nunoo J., Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., RA Yu C., Lewis S.E., Rubin G.M., Celniker S.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [6] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:ABI34852.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=0 {ECO:0000313|EMBL:ABI34852.1}, 2 RC {ECO:0000313|EMBL:ABI34853.1}, and 3 {ECO:0000313|EMBL:ABI34854.1}; RA Wiggins B.L., Malik H.S.; RT "Positive selection of Drosophila cdc6, an essential DNA replication- RT licensing gene, suggests an adaptive choice of replication origins."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RA O'Boyle S.T.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [12] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [13] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014296; AAF50387.1; -; Genomic_DNA. DR EMBL; AY051722; AAK93146.1; -; mRNA. DR EMBL; DQ839683; ABI34852.1; -; Genomic_DNA. DR EMBL; DQ839684; ABI34853.1; -; Genomic_DNA. DR EMBL; DQ839685; ABI34854.1; -; Genomic_DNA. DR RefSeq; NP_648247.1; NM_139990.3. DR UniGene; Dm.4495; -. DR IntAct; Q9VSM9; 6. DR MINT; MINT-1579012; -. DR STRING; 7227.FBpp0076371; -. DR EnsemblMetazoa; FBtr0076647; FBpp0076371; FBgn0035918. DR GeneID; 38989; -. DR KEGG; dme:Dmel_CG5971; -. DR UCSC; CG5971-RA; d. melanogaster. DR CTD; 990; -. DR FlyBase; FBgn0035918; Cdc6. DR eggNOG; KOG2227; Eukaryota. DR eggNOG; COG1474; LUCA. DR GeneTree; ENSGT00530000063498; -. DR KO; K02213; -. DR OMA; DHMAAAL; -. DR OrthoDB; EOG091G0AXO; -. DR Reactome; R-DME-176187; Activation of ATR in response to replication stress. DR Reactome; R-DME-68689; CDC6 association with the ORC:origin complex. DR Reactome; R-DME-68827; CDT1 association with the CDC6:ORC:origin complex. DR Reactome; R-DME-68867; Assembly of the pre-replicative complex. DR Reactome; R-DME-68949; Orc1 removal from chromatin. DR Reactome; R-DME-68962; Activation of the pre-replicative complex. DR Reactome; R-DME-69017; CDK-mediated phosphorylation and removal of Cdc6. DR Reactome; R-DME-69298; Association of licensing factors with the pre-replicative complex. DR Reactome; R-DME-69300; Removal of licensing factors from origins. DR GenomeRNAi; 38989; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0035918; -. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0051301; P:cell division; IEA:InterPro. DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro. DR CDD; cd08768; Cdc6_C; 1. DR Gene3D; 1.10.10.10; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR016314; Cdc6/18. DR InterPro; IPR015163; Cdc6_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF13401; AAA_22; 1. DR Pfam; PF09079; Cdc6_C; 1. DR PIRSF; PIRSF001767; Cdc6; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM01074; Cdc6_C; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q9VSM9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 289 434 AAA. {ECO:0000259|SMART:SM00382}. FT DOMAIN 564 644 Cdc6_C. {ECO:0000259|SMART:SM01074}. SQ SEQUENCE 662 AA; 75135 MW; 7EC3E0655FA8BCB0 CRC64; MAAVRRSTRL SSISKATAAS PLPPSTQTPR RSEVWKRRQP KKVLADSDEE EEVVTAIYDL TSPVSENNEN RNVLNKMDKI SRRRTSQVQV AQSELPKTPR STKKTVQSAG SSRAKREEEN REATARFLEG EQDSEVDPLH GSPPKQRKLQ PLPQHLISPS RLLDRLSIDE RQEEEVEATT HKTETAEQQP KHQAKDEAKP RPKQQEDPLA QKQQEKPPTK QPNKNQTKEK SNIQTNEETQ QNNLPSPSRN KYQNARRVLN SAETQNLPGR ESQLQELREF FSNHLESQTS GSLYVSGQPG TGKTACLSLL LRDPDFSKRL QRVYINCTSI ASVGAVYKKL CTELQLKVSG RTERDHLEAI QRHLKTAKRM LLLVLDEIDQ LCTSRQEVLY TIFEWPALPG SRILLVGIAN SLDLTDRALM RLNARCELKP RLMHFPPYSK QQIVEIFKSR LAEAEVLDVF PPVTLQLLAA KVSAISGDVR RALDIGRRVV EIAEQQKRDG EKEFNMKALQ LEGKDAVEAK EKQDTLKPVQ VTQVAAVLNK VYGASQNLEE DIEASFPLQQ KLMLCTLVLM LRNERNKDIS MGRLHEVYRR VCAKRNILAL DQAEFTGTVD LVETRGILRI MRKKEPRLHK VLLQWDEEEV HAALSDKQLI ASILSDTACL SK //