ID Q9VSM9_DROME Unreviewed; 662 AA. AC Q9VSM9; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 04-FEB-2015, entry version 128. DE SubName: Full=CG5971-PA {ECO:0000313|EMBL:AAF50387.1}; DE SubName: Full=Cdc6 {ECO:0000313|EMBL:ABI34852.1}; DE SubName: Full=LD25083p {ECO:0000313|EMBL:AAK93146.1}; GN Name=Cdc6 {ECO:0000313|FlyBase:FBgn0035918}; GN Synonyms=cdc6 {ECO:0000313|EMBL:ABI34852.1}; GN ORFNames=CG5971 {ECO:0000313|EMBL:AAF50387.1, GN ECO:0000313|FlyBase:FBgn0035918}, Dmel_CG5971 GN {ECO:0000313|EMBL:AAF50387.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAK93146.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAK93146.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., RA Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., RA Nunoo J., Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., RA Yu C., Lewis S.E., Rubin G.M., Celniker S.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [5] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [6] {ECO:0000313|EMBL:AAF50387.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [7] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [8] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [9] {ECO:0000313|EMBL:AAF50387.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:ABI34852.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=0 {ECO:0000313|EMBL:ABI34852.1}, 2 RC {ECO:0000313|EMBL:ABI34853.1}, and 3 {ECO:0000313|EMBL:ABI34854.1}; RA Wiggins B.L., Malik H.S.; RT "Positive selection of Drosophila cdc6, an essential DNA replication- RT licensing gene, suggests an adaptive choice of replication origins."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [12] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE003554; AAF50387.1; -; Genomic_DNA. DR EMBL; AY051722; AAK93146.1; -; mRNA. DR EMBL; DQ839683; ABI34852.1; -; Genomic_DNA. DR EMBL; DQ839684; ABI34853.1; -; Genomic_DNA. DR EMBL; DQ839685; ABI34854.1; -; Genomic_DNA. DR RefSeq; NP_648247.1; NM_139990.3. DR UniGene; Dm.4495; -. DR ProteinModelPortal; Q9VSM9; -. DR MINT; MINT-1579012; -. DR STRING; 7227.FBpp0076371; -. DR EnsemblMetazoa; FBtr0076647; FBpp0076371; FBgn0035918. DR GeneID; 38989; -. DR KEGG; dme:Dmel_CG5971; -. DR UCSC; CG5971-RA; d. melanogaster. DR CTD; 990; -. DR FlyBase; FBgn0035918; Cdc6. DR GeneTree; ENSGT00530000063498; -. DR KO; K02213; -. DR OMA; INCTSIA; -. DR OrthoDB; EOG7QG44J; -. DR Reactome; REACT_180285; G1/S-Specific Transcription. DR Reactome; REACT_180658; G0 and Early G1. DR Reactome; REACT_209388; E2F mediated regulation of DNA replication. DR Reactome; REACT_209977; Activation of the pre-replicative complex. DR Reactome; REACT_211248; CDK-mediated phosphorylation and removal of Cdc6. DR Reactome; REACT_218568; Activation of ATR in response to replication stress. DR Reactome; REACT_218589; Orc1 removal from chromatin. DR Reactome; REACT_227797; Removal of licensing factors from origins. DR Reactome; REACT_231175; CDT1 association with the CDC6:ORC:origin complex. DR Reactome; REACT_239790; Assembly of the pre-replicative complex. DR Reactome; REACT_248239; CDC6 association with the ORC:origin complex. DR Reactome; REACT_259623; Association of licensing factors with the pre-replicative complex. DR GenomeRNAi; 38989; -. DR NextBio; 811345; -. DR Proteomes; UP000000803; Chromosome 3L. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR Gene3D; 1.10.10.10; -; 1. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR015163; Cdc6_C_dom. DR InterPro; IPR016314; Cell_div_Cdc6/18. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF09079; Cdc6_C; 1. DR PIRSF; PIRSF001767; Cdc6; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM01074; Cdc6_C; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|RuleBase:RU003299}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU003299}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. SQ SEQUENCE 662 AA; 75135 MW; 7EC3E0655FA8BCB0 CRC64; MAAVRRSTRL SSISKATAAS PLPPSTQTPR RSEVWKRRQP KKVLADSDEE EEVVTAIYDL TSPVSENNEN RNVLNKMDKI SRRRTSQVQV AQSELPKTPR STKKTVQSAG SSRAKREEEN REATARFLEG EQDSEVDPLH GSPPKQRKLQ PLPQHLISPS RLLDRLSIDE RQEEEVEATT HKTETAEQQP KHQAKDEAKP RPKQQEDPLA QKQQEKPPTK QPNKNQTKEK SNIQTNEETQ QNNLPSPSRN KYQNARRVLN SAETQNLPGR ESQLQELREF FSNHLESQTS GSLYVSGQPG TGKTACLSLL LRDPDFSKRL QRVYINCTSI ASVGAVYKKL CTELQLKVSG RTERDHLEAI QRHLKTAKRM LLLVLDEIDQ LCTSRQEVLY TIFEWPALPG SRILLVGIAN SLDLTDRALM RLNARCELKP RLMHFPPYSK QQIVEIFKSR LAEAEVLDVF PPVTLQLLAA KVSAISGDVR RALDIGRRVV EIAEQQKRDG EKEFNMKALQ LEGKDAVEAK EKQDTLKPVQ VTQVAAVLNK VYGASQNLEE DIEASFPLQQ KLMLCTLVLM LRNERNKDIS MGRLHEVYRR VCAKRNILAL DQAEFTGTVD LVETRGILRI MRKKEPRLHK VLLQWDEEEV HAALSDKQLI ASILSDTACL SK //