ID LIN28_DROME Reviewed; 195 AA. AC Q9VRN5; DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 2. DT 13-JUL-2010, entry version 82. DE RecName: Full=Protein lin-28 homolog; GN Name=lin-28; ORFNames=CG17334; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE. RX MEDLINE=22682989; PubMed=12798299; DOI=10.1016/S0012-1606(03)00126-X; RA Moss E.G., Tang L.; RT "Conservation of the heterochronic regulator Lin-28, its developmental RT expression and microRNA complementary sites."; RL Dev. Biol. 258:432-442(2003). RN [2] RP ERRATUM. RA Moss E.G., Tang L.; RL Dev. Biol. 262:361-361(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- DEVELOPMENTAL STAGE: Expressed from embryogenesis to the first CC instar larval stage, then at the pupal stage. Not expressed at CC significant levels in the adult. CC -!- SIMILARITY: Belongs to the lin-28 family. CC -!- SIMILARITY: Contains 2 CCHC-type zinc fingers. CC -!- SIMILARITY: Contains 1 CSD (cold-shock) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF521096; AAM77748.1; -; mRNA. DR EMBL; AE014296; AAF50758.2; -; Genomic_DNA. DR EMBL; AY118360; AAM48389.1; -; mRNA. DR RefSeq; NP_647983.1; -. DR UniGene; Dm.13816; -. DR HSSP; O54310; 1G6P. DR SMR; Q9VRN5; 18-111, 123-173. DR STRING; Q9VRN5; -. DR EnsemblMetazoa; FBtr0077090; FBpp0076798; FBgn0035626. DR GeneID; 38639; -. DR KEGG; dme:Dmel_CG17334; -. DR NMPDR; fig|7227.3.peg.8263; -. DR UCSC; CG17334-RA; d. melanogaster. DR CTD; 38639; -. DR FlyBase; FBgn0035626; lin-28. DR eggNOG; inNOG10035; -. DR InParanoid; Q9VRN5; -. DR OMA; FANHIAS; -. DR OrthoDB; EOG9NKC3B; -. DR PhylomeDB; Q9VRN5; -. DR NextBio; 809656; -. DR ArrayExpress; Q9VRN5; -. DR Bgee; Q9VRN5; -. DR GermOnline; CG17334; Drosophila melanogaster. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. DR InterPro; IPR011129; Cold_shock_prot. DR InterPro; IPR002059; CSP_DNA-bd. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR016027; NA-bd_OB-fold-like. DR InterPro; IPR013084; Znf_CCH_retrovir. DR InterPro; IPR001878; Znf_CCHC. DR Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1. DR Gene3D; G3DSA:4.10.60.10; Znf_CCH_retrovir; 1. DR Pfam; PF00313; CSD; 1. DR PRINTS; PR00050; COLDSHOCK. DR SMART; SM00357; CSP; 1. DR SMART; SM00343; ZnF_C2HC; 2. DR SUPFAM; SSF50249; Nucleic_acid_OB; 1. DR PROSITE; PS50158; ZF_CCHC; FALSE_NEG. PE 2: Evidence at transcript level; KW Complete proteome; Cytoplasm; Metal-binding; Repeat; Zinc; KW Zinc-finger. FT CHAIN 1 195 Protein lin-28 homolog. FT /FTId=PRO_0000253797. FT DOMAIN 38 104 CSD. FT ZN_FING 126 143 CCHC-type 1. FT ZN_FING 148 165 CCHC-type 2. FT METAL 127 127 Zinc 1 (By similarity). FT METAL 130 130 Zinc 1 (By similarity). FT METAL 136 136 Zinc 1 (By similarity). FT METAL 141 141 Zinc 1 (By similarity). FT METAL 150 150 Zinc 2 (By similarity). FT METAL 153 153 Zinc 2 (By similarity). FT METAL 158 158 Zinc 2 (By similarity). FT METAL 163 163 Zinc 2 (By similarity). SQ SEQUENCE 195 AA; 21594 MW; 4F2E080F20137EA5 CRC64; MENVQLENGL ERRTTSQSST SSANPANLAS PTEECGCVRL GKCKWFNVAK GWGFLTPNDG GQEVFVHQSV IQMSGFRSLG EQEEVEFECQ RTSRGLEATR VSSRHGGSCQ GSTYRPRINR RTRRMRCYNC GEFANHIASE CALGPQPKRC HRCRGEDHLH ADCPHKNVTQ SHSNSKSISN NSSSSAAQEK SEEAT //