ID LIN28_DROME Reviewed; 195 AA. AC Q9VRN5; DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 2. DT 11-DEC-2019, entry version 140. DE RecName: Full=Protein lin-28 homolog; GN Name=lin-28; ORFNames=CG17334; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE. RX PubMed=12798299; DOI=10.1016/s0012-1606(03)00126-x; RA Moss E.G., Tang L.; RT "Conservation of the heterochronic regulator Lin-28, its developmental RT expression and microRNA complementary sites."; RL Dev. Biol. 258:432-442(2003). RN [2] RP ERRATUM. RA Moss E.G., Tang L.; RL Dev. Biol. 262:361-361(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A., RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. CC -!- DEVELOPMENTAL STAGE: Expressed from embryogenesis to the first instar CC larval stage, then at the pupal stage. Not expressed at significant CC levels in the adult. {ECO:0000269|PubMed:12798299}. CC -!- SIMILARITY: Belongs to the lin-28 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF521096; AAM77748.1; -; mRNA. DR EMBL; AE014296; AAF50758.2; -; Genomic_DNA. DR EMBL; AY118360; AAM48389.1; -; mRNA. DR RefSeq; NP_647983.1; NM_139726.2. DR SMR; Q9VRN5; -. DR BioGrid; 64102; 4. DR IntAct; Q9VRN5; 2. DR STRING; 7227.FBpp0076798; -. DR PaxDb; Q9VRN5; -. DR PRIDE; Q9VRN5; -. DR EnsemblMetazoa; FBtr0077090; FBpp0076798; FBgn0035626. DR GeneID; 38639; -. DR KEGG; dme:Dmel_CG17334; -. DR UCSC; CG17334-RA; d. melanogaster. DR CTD; 38639; -. DR FlyBase; FBgn0035626; lin-28. DR eggNOG; KOG3070; Eukaryota. DR eggNOG; COG1278; LUCA. DR GeneTree; ENSGT00940000171032; -. DR InParanoid; Q9VRN5; -. DR KO; K18754; -. DR OMA; NHIASEC; -. DR OrthoDB; 1604809at2759; -. DR PhylomeDB; Q9VRN5; -. DR GenomeRNAi; 38639; -. DR PRO; PR:Q9VRN5; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0035626; Expressed in 35 organ(s), highest expression level in embryo. DR Genevisible; Q9VRN5; DM. DR GO; GO:0005829; C:cytosol; IDA:FlyBase. DR GO; GO:0003729; F:mRNA binding; IDA:FlyBase. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:2000632; P:negative regulation of pre-miRNA processing; IMP:FlyBase. DR GO; GO:0048477; P:oogenesis; IMP:FlyBase. DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IMP:FlyBase. DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:FlyBase. DR GO; GO:0098724; P:symmetric stem cell division; IMP:FlyBase. DR CDD; cd04458; CSP_CDS; 1. DR InterPro; IPR011129; CSD. DR InterPro; IPR002059; CSP_DNA-bd. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR001878; Znf_CCHC. DR InterPro; IPR036875; Znf_CCHC_sf. DR Pfam; PF00313; CSD; 1. DR PRINTS; PR00050; COLDSHOCK. DR SMART; SM00357; CSP; 1. DR SMART; SM00343; ZnF_C2HC; 2. DR SUPFAM; SSF50249; SSF50249; 1. DR SUPFAM; SSF57756; SSF57756; 1. DR PROSITE; PS51857; CSD_2; 1. PE 2: Evidence at transcript level; KW Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. FT CHAIN 1..195 FT /note="Protein lin-28 homolog" FT /id="PRO_0000253797" FT DOMAIN 38..104 FT /note="CSD" FT ZN_FING 126..143 FT /note="CCHC-type 1" FT ZN_FING 148..165 FT /note="CCHC-type 2" FT METAL 127 FT /note="Zinc 1" FT /evidence="ECO:0000250" FT METAL 130 FT /note="Zinc 1" FT /evidence="ECO:0000250" FT METAL 136 FT /note="Zinc 1" FT /evidence="ECO:0000250" FT METAL 141 FT /note="Zinc 1" FT /evidence="ECO:0000250" FT METAL 150 FT /note="Zinc 2" FT /evidence="ECO:0000250" FT METAL 153 FT /note="Zinc 2" FT /evidence="ECO:0000250" FT METAL 158 FT /note="Zinc 2" FT /evidence="ECO:0000250" FT METAL 163 FT /note="Zinc 2" FT /evidence="ECO:0000250" SQ SEQUENCE 195 AA; 21594 MW; 4F2E080F20137EA5 CRC64; MENVQLENGL ERRTTSQSST SSANPANLAS PTEECGCVRL GKCKWFNVAK GWGFLTPNDG GQEVFVHQSV IQMSGFRSLG EQEEVEFECQ RTSRGLEATR VSSRHGGSCQ GSTYRPRINR RTRRMRCYNC GEFANHIASE CALGPQPKRC HRCRGEDHLH ADCPHKNVTQ SHSNSKSISN NSSSSAAQEK SEEAT //