ID Q9VRN5 PRELIMINARY; PRT; 195 AA. AC Q9VRN5; DT 01-MAY-2000 (TrEMBLrel. 13, Created) DT 01-OCT-2002 (TrEMBLrel. 22, Last sequence update) DT 01-JUN-2003 (TrEMBLrel. 24, Last annotation update) DE CG17334 protein (RE05342p) (RNA-binding protein LIN-28). GN LIN-28 OR CG17334. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP SEQUENCE FROM N.A. RA Celniker S.E., Adams M.D., Kronmiller B., Wan K.H., Holt R.A., RA Evans C.A., Gocayne J.D., Amanatides P.G., Brandon R.C., Rogers Y., RA Banzon J., An H., Baldwin D., Banzon J., Beeson K.Y., Busam D.A., RA Carlson J.W., Center A., Champe M., Davenport L.B., Dietz S.M., RA Dodson K., Dorsett V., Doup L.E., Doyle C., Dresnek D., Farfan D., RA Ferriera S., Frise E., Galle R.F., Garg N.S., George R.A., RA Gonzalez M., Houck J., Hoskins R.A., Hostin D., Howland T.J., RA Ibegwam C., Jalali M., Kruse D., Li P., Mattei B., Moshrefi A., RA McIntosh T.C., Moy M., Murphy B., Nelson C., Nelson K.A., Nunoo J., RA Pacleb J., Paragas V., Park S., Patel S., Pfeiffer B., RA Phouanenavong S., Pittman G.S., Puri V., Richards S., Scheeler F., RA Stapleton M., Strong R., Svirskas R., Tector C., Tyler D., RA Williams S.M., Zaveri J.S., Smith H.O., Venter J.C., Rubin G.M.; RT "Sequencing of Drosophila melanogaster genome."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RA Misra S., Crosby M.A., Matthews B.B., Bayraktaroglu L., Campbell K., RA Hradecky P., Huang Y., Kaminker J.S., Prochnik S.E., Smith C.D., RA Tupy J.L., Bergman C., Berman B., Carlson J.W., Celniker S.E., RA Clamp M., Drysdale R., Emmert D., Frise E., de Grey A., Harris N., RA Kronmiller B., Marshall B., Millburn G., Richter J., Russo S., RA Searle S.M.J., Smith E., Shu S., Smutniak F., Whitfield E., RA Ashburner M., Gelbart W.M., Rubin G.M., Mungall C.J., Lewis S.E.; RT "Annotation of Drosophila melanogaster genome."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RA Adams M.D., Celniker S.E., Gibbs R.A., Rubin G.M., Venter C.J.; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RA FlyBase; RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE FROM N.A. RC STRAIN=Berkeley; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [7] RP SEQUENCE FROM N.A. RA Moss E.G., Tang L.; RT "The heterochronic regulator LIN-28 is conserved and developmentally RT expressed in diverse animals."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: BELONGS TO THE COLD-SHOCK DOMAIN (CSD) FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE003565; AAF50758.2; -. DR EMBL; AY118360; AAM48389.1; -. DR EMBL; AF521096; AAM77748.1; -. DR HSSP; P41016; 1C9O. DR FlyBase; FBgn0035626; lin-28. DR GO; GO:0003677; F:DNA binding activity; IEA. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA. DR InterPro; IPR002059; Cold_shock. DR InterPro; IPR001878; Znf_CCHC. DR Pfam; PF00313; CSD; 1. DR Pfam; PF00098; zf-CCHC; 1. DR PRINTS; PR00050; COLDSHOCK. DR ProDom; PD000621; Cold_shock; 1. DR SMART; SM00357; CSP; 1. DR SMART; SM00343; ZnF_C2HC; 2. SQ SEQUENCE 195 AA; 21594 MW; 4F2E080F20137EA5 CRC64; MENVQLENGL ERRTTSQSST SSANPANLAS PTEECGCVRL GKCKWFNVAK GWGFLTPNDG GQEVFVHQSV IQMSGFRSLG EQEEVEFECQ RTSRGLEATR VSSRHGGSCQ GSTYRPRINR RTRRMRCYNC GEFANHIASE CALGPQPKRC HRCRGEDHLH ADCPHKNVTQ SHSNSKSISN NSSSSAAQEK SEEAT //