ID Q9VR90_DROME Unreviewed; 352 AA. AC Q9VR90; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 19-JAN-2022, entry version 164. DE SubName: Full=Syntaxin 16 {ECO:0000313|EMBL:AAF50914.1}; GN Name=Syx16 {ECO:0000313|EMBL:AAF50914.1, GN ECO:0000313|FlyBase:FBgn0031106}; GN Synonyms=Dm Syx16 {ECO:0000313|EMBL:AAF50914.1}, Dmel\CG1467 GN {ECO:0000313|EMBL:AAF50914.1}, DmSyx16 {ECO:0000313|EMBL:AAF50914.1}, GN dSyx 16 {ECO:0000313|EMBL:AAF50914.1}, dSyx16 GN {ECO:0000313|EMBL:AAF50914.1}, Syx {ECO:0000313|EMBL:AAF50914.1}, GN SYX16 {ECO:0000313|EMBL:AAF50914.1}; GN ORFNames=CG1467 {ECO:0000313|EMBL:AAF50914.1, GN ECO:0000313|FlyBase:FBgn0031106}, Dmel_CG1467 GN {ECO:0000313|EMBL:AAF50914.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AAF50914.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single- CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}. CC -!- SIMILARITY: Belongs to the syntaxin family. CC {ECO:0000256|ARBA:ARBA00009063}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AAF50914.1; -; Genomic_DNA. DR RefSeq; NP_523420.1; NM_078696.3. DR SMR; Q9VR90; -. DR IntAct; Q9VR90; 4. DR STRING; 7227.FBpp0077022; -. DR PaxDb; Q9VR90; -. DR PRIDE; Q9VR90; -. DR EnsemblMetazoa; FBtr0077330; FBpp0077022; FBgn0031106. DR GeneID; 33034; -. DR KEGG; dme:Dmel_CG1467; -. DR UCSC; CG1467-RA; d. melanogaster. DR CTD; 33034; -. DR FlyBase; FBgn0031106; Syx16. DR VEuPathDB; VectorBase:FBgn0031106; -. DR eggNOG; KOG0809; Eukaryota. DR GeneTree; ENSGT01000000214380; -. DR HOGENOM; CLU_038177_3_0_1; -. DR InParanoid; Q9VR90; -. DR OMA; QTMIIDQ; -. DR OrthoDB; 1182451at2759; -. DR PhylomeDB; Q9VR90; -. DR Reactome; R-DME-6811438; Intra-Golgi traffic. DR Reactome; R-DME-6811440; Retrograde transport at the Trans-Golgi-Network. DR BioGRID-ORCS; 33034; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 33034; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0031106; Expressed in spermathecum and 34 other tissues. DR ExpressionAtlas; Q9VR90; baseline and differential. DR Genevisible; Q9VR90; DM. DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central. DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase. DR GO; GO:0000139; C:Golgi membrane; IC:FlyBase. DR GO; GO:0000138; C:Golgi trans cisterna; IDA:FlyBase. DR GO; GO:0016021; C:integral component of membrane; IDA:FlyBase. DR GO; GO:0005764; C:lysosome; IDA:FlyBase. DR GO; GO:0005886; C:plasma membrane; ISS:FlyBase. DR GO; GO:0098793; C:presynapse; IEA:GOC. DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central. DR GO; GO:0005484; F:SNAP receptor activity; IPI:FlyBase. DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central. DR GO; GO:0048193; P:Golgi vesicle transport; IMP:FlyBase. DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central. DR GO; GO:0007269; P:neurotransmitter secretion; NAS:FlyBase. DR GO; GO:0016081; P:synaptic vesicle docking; ISS:FlyBase. DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central. DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central. DR GO; GO:0016192; P:vesicle-mediated transport; NAS:FlyBase. DR InterPro; IPR010989; SNARE. DR InterPro; IPR028673; STX16. DR InterPro; IPR045242; Syntaxin. DR InterPro; IPR006012; Syntaxin/epimorphin_CS. DR InterPro; IPR000727; T_SNARE_dom. DR PANTHER; PTHR19957; PTHR19957; 1. DR PANTHER; PTHR19957:SF83; PTHR19957:SF83; 1. DR Pfam; PF05739; SNARE; 1. DR SMART; SM00397; t_SNARE; 1. DR SUPFAM; SSF47661; SSF47661; 1. DR PROSITE; PS00914; SYNTAXIN; 1. DR PROSITE; PS50192; T_SNARE; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE- KW ProRule:PRU00202}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9VR90}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 331..349 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 258..320 FT /note="T-SNARE coiled-coil homology" FT /evidence="ECO:0000259|PROSITE:PS50192" SQ SEQUENCE 352 AA; 40399 MW; B28E70EEF09FA570 CRC64; MTSRNLTEVF VIMRNNASKN RNHYDDRRGS DAERLLKHSV REAEEGLELQ DDYGTPPAWL DKFEEAQYTM SKIKPKLDEL GSLHARHLLR PAFDDQRDDE CDIEVLSQIV SKLITSTHRH IQCVRSSIGV GSKMEQCLTV NAVHCALLQL QELTVKFRAS QNAYLLQLNS REERSQKYFD DGGGAGAGDV FTNVELGEQS AENFVDSFDN FLQPPAEGKS GNGYLFEDDE QAIDDHFQRP PASRMTQQQL LLFEEENTRV AQHREQEVTK IVKSIYDLND IFKDLGHMVQ EQGTVLDRID YNVEQTQTRV SEGLRQLHKA EMYQRKNRKM CVILVLAAVT FFMLLLLILT KL //