ID Q9VPL1 PRELIMINARY; PRT; 5560 AA. AC Q9VPL1; DT 01-MAY-2000 (TrEMBLrel. 13, Created) DT 01-MAR-2001 (TrEMBLrel. 16, Last sequence update) DT 01-JUN-2003 (TrEMBLrel. 24, Last annotation update) DE Spen protein. GN SPEN OR CG18497. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE003590; AAF51535.2; -. DR HSSP; P09651; 1HA1. DR FlyBase; FBgn0016977; spen. DR GO; GO:0003676; F:nucleic acid binding activity; IEA. DR InterPro; IPR000504; RNA_rec_mot. DR Pfam; PF00076; rrm; 3. DR SMART; SM00360; RRM; 3. DR PROSITE; PS50102; RRM; 3. SQ SEQUENCE 5560 AA; 599996 MW; 58F19621AF40D2A8 CRC64; MFRCRNMVRD NSRNICFGKL AETTTTQQQQ QQQQFVVDSS TIINNNNNNN NNNNNQKLKR STEEPPTNSF ERNYYDRTTS RLVTQYQANN STSLANSNSS PSSVSASASV FATAAGGSSE RSRNRDRPYR NGSASVQGGG INSSNTTTTT AACTAGGSGS GAIGTGTGGL VGSGPGGVPQ ALGDRSSTQN IHQNHQSARV APPQSWYEAA TAATTAQLKS SGGSGNAGAS AAVGFTMSSS PINHHPHQHP HLQNPQHPHY TSSPVVGAGS CPSAAQGQPQ IQSQSQTTAV HRSVAYAGSA ADDLLNTATS RNMLLHSSKL NKLLKGAGAT GSGGERSGSE SPGRAGGATP LTTTSTITNN SFSSNSLNNT ITTATPTMPT IASGAAGSVG LGSGAEAGVC SNSGTASGDI LNVAAVLAAA VDNGVPTHPI RTRHNLHGRS TTSSSRSHSR SPSSYSSSHS SSSSSHSSSH SHASSPVQSS GNCAMAEGRS SRTVNSVTVT SNSSNPSGTA VTVSSAGVGG GCGSSSSSSS SSSSSGSSCL TANPVVHSED NRPLAIRVRN LPARSSDTSL KDGLFHEYKK HGKVTWVKVV GQNSERYALV CFKKPDDVEK ALEVSHDKHF FGCKIEVEPY QGYDVEDNEF RPYEAELDEY HPKSTRTLFI GNLEKDITAG ELRSHFEAFG EIIEIDIKKQ GLNAYAFCQY SDIVSVVKAM RKMDGEHLGS NRIKLGFGKS MPTNCVWIDG VDEKVSESFL QSQFTRFGAV TKVSIDRNRQ LALVLYDQVQ NAQAAVKDMR GTILRRKKLQ VDFASRECQD AFYDKQEKQQ QQSSGSNPRF SRYESSASSL QSRSRASSFS RHQNNSNDDC SPINTPGGAS SGISSASNLI NQSTSINISN IGTNACSAMP APSLASAVVS CNVNASGTVP ASTSMPSGVS SSSSSLPMSP AALAQRHRMV RNARQTVDCD FNEVGRLRFR SSEEVSGGAG NSTQFEDVRC DSPVTARQGS AVNCFTGPTA AVGESIDGTL NNNQITGGAE GFTGSGGSIL SRRRCGKTPK DLHPVHNQRI QLAEQVEECP SSGDEGVVSP RKRIKMDYHH HHHHSNASGV ESTGEHSSIN KPSPLLLSNC DVIHDPLNRK SEIRRVSETP SGSPSIKFPG HLPSAPQSLM LSCRRPSIDV GALSALSSSS AFRHGIVGAS SMDQQHMMNA SAAAKRRRVT TTMQQPSSSS TTNSSSGSGL GGISSLTPAD EYHHHVSRGR GHQLHSHHSH EASGGESADG SRPGTPLCDE RPEVLPTEPR RLPPPRERVR ERTRDVMWLP LPKFGVLFFQ QQQSRSSGGG GAGNSYLQQQ LGGGSTGGLG CIGAASSSAC SLNNSSLNAS QGMGSCSGST FLPSPSSRYW RSSSHHQNQQ NNHQQQSQQL HGSSSSNTCL MASPARPRSL SSNSSDSDVP GQNAGGSPSL DERLRNFEEN YERWSGGSSR EHISGHTPSS ATPSWQLSMH MNLSTGLNSH QTSSASGNSN SSSGTVSSSA SNSRHKFLDI DELQPSDIVK SVLAKKSVFD DDFQRLNKNQ WYDPSSSDFA LGSSSNIVTG SSLVANVSRH PGGPCSGNTS PALPNLAATK ATPIIGNCSG GLGNSTGSKS AGLLQRLSSL SPMNSPQASM SPYNSPSPSP SVGGVTACLG QLTKPAAPGT ASAGLSGGTA ASSSSPAANS GPTKGLQYPF PSHPPLPNTA APPPAVQPAP PPLPEMGKQS RLTGQSSGNN LTKSLSVPDG PQSSPARVQL QKSASVPGST NVGAPSSLSL DSTTASVETS ASISSSTSNG NSSLTSAAIH VQKPQQSTFV EEEHTKKSGT STSQSSSSSS KKISSTHDKL HSKHNNRSES DKKIKKSDKN ASSSDKRKNS STSQSSKSAT PRIEDDSSEA DDTADKAEKN QRHEKEKKER QEKREKDLRK QVEREEKDRK AQQEEREKED RKAKEEEKER EREKKAQEDR EKKEREEREL REKEQRDKEQ KEKEIREKDL REKEQRERDN REKELRDKDL REKEMREKEQ REKELHREKD QREREHREKE QSRRAMDVEQ EGRGGRMREL SSYQKSKMDI AGEASSLTAI DCQHNKENAM DTIAQGTPGA SPSTPSDNTP KERSRKLSRN SPVRLHKRRL SSQESNHSAG GGGSCGGSSH QIHHEDYVKR IRMENSQNIS VHSSNQRLND RRDSKEHKSS SFKEDKNSSS HISRPHGCGG SSASSSKHHH RRDKHHQKGS ASSIETNSSI EVVVDPISQT KHNLNTSEEE LQSHQPKREK EREHFSSHAN SSSSRHKSKR DHHHHREKKR HSVAESTNTD EEHTPQQHNP HRRISAAGSG SAGELSSAAT NTSSGKLHHQ HHRRSVERKS SRGSDEGHHS SSKSLRAKLM MLSSADSDDT DDASKKHSIF DIPDDCPNVS MYDKVKARSC KNMQRQAEEK KIKAKFSQLK QSRAKKKRST SYDGDSDTEF EDRQHRNSGS SSFHGRYPGL SSSDDDDDEE THQRRISSDS DAEHGGQDNQ GASTLADANR VRQMQQNLRR LCDGDDSSED EIRRNVMKHS HFGKRNSNST RIASDSESQS QPAPDLTIKQ EHPIAPAQEI KREQLSDEEQ KFKSRHDSNS SIEERKLKTE REIKTELGDF YNSSEYTYTG KLKEYSPETR KKHKKSKRRL KSSSTADTSA AQTPLVMTPL TPSIFDVHSS SECKTKFDNF DDLKTECSSI PLEISAGERR KHKERKEKKR EKLRNMTEAT VPNSPTTNDT SSEKLSKEER HRLKKSKKSK SMDNSCNTKI YNSSGAHPST SPSLPATPTS APSTAQTSKR GEDKMEFIFG IISDEEESQF PEQAETNKDI IPSSVSTTGP IVSAALQTYK QEPSTPNSKN EEAHIQLTVH EPEQQQQLER SRLSGGSSSS SHADRERHRR EKREKKRREK SQREQQNQIH QKSSKVETKV DDDNSVDMDE AGRALEAQLM SDFDTKPISE EATPSTAATY RSDMTDVFRF SDNEDNNSVD MTKQGVKSEQ QEQHKSKDKK KKKKRSKEEK QEKLLQQQRR ESLPNVASTS SAPPTPGKLT VNVQAASKHA DLQLDAKHIS SPPVCKPSPS LPCLIGDDDD DALHTPKAKP TTPSSRGNDG LTPSREKPRL ISPIPKTPTI ANSSTLSTQS AETPVSSGTV ISSSALATTP TSSTAAGVSA APGLDNSPTS ASAQCKKKES FIPGFDGQLD DRISESAVQS ISAEFNSTSL LDNIADEPKI PVASPPRATK PLDKLEESKS RVTISQEETE SAVSALLGES FGTSSTTDYS LDGMDEMSSV NELETPTLVI AEPDEEAALA AKAIETAGEP ASILEEPEME PEREAEPDPD PEAEIESEPV VEVLDPEELN KAVQSLKHED MMDIKADTPQ SERDLQIDTD TEENPDEADS SGPSLKIDET VQSSSSPEKS ISNNSPTPRE TANIDIPNVE SQPKLSNEST PQPSVITKLP FLDTPKTVPA GLPPSPVKIE PPTISKLQQP LVQPVQTVLP APHSTGSGIS ANSVINLDLS NVISSCSNTS AASATASASA SISFGSPTAS QNAMPQASTP KQGPITPQQA IRTQSLIMQP PTISIPEQTP HFAVPQMVLS PQSHHPQQPG TYMVGIRAPS PHSPLHSPGR GVAQSRLVGQ LSPVGRPMVS QPSPQQQVQQ TQQQHALITS PQSSNISPLA SPTTRVLSSS NSPTTSKVNS YQPRNQQVPQ QPSPKSVAEV QTTPQLMTIP LQKMTPIQVP HHPTIISKVV TVQPQQATQS QVASSPPLGS LPPHKNVHLN AHQNQQQPQV IAKMTAHQHQ QHMQQFMHQQ MIQRQQHMQQ QQLHGQSQQI TSAPQHQMHQ QHQAQQQQQH HNQQHLNQQL HAQQHPTQKQ HQAQQQFNQQ IQQHQSQQQH QVQQQNQAQQ QHLSQQQHQS QQQLNQQHQA QQQQLQQIQK LQQMHGPQQQ QKSPQGVGHL GGSTSIFASQ QHNSQLPARG VPQQQHPQQL SHSSPCKPNT LVSVNQGVQP PAILTRVGSH SQPNQQQQLP HQQSSSGHPH QKQLSSPGAN LPLQTPLNVI QNTPKIIVQQ HIVAQNQVPP PQTQGNAIHY PQNQGKDSTP PGHVEPTPAM SAQKTSESVS VIRTPTPTTG LAVISANTVG SLLTEENLIK ISQPKQDELI EQDSKEVDSD YWSAKEVNID SVIKKLDTPL ASKDAKRAVE MQAIAPAPIP NPQPGNQSMA QETALPTTSM SVNNSNDHDT EDETETRQLP PAKPPIPTVG RPPGRGGSAK RGRQPRGAKK VGGFPLNSVT AAPPGVDSLV VQPGDNGVQT RLRKPVTAPV TRGRKGRPPR NLLLQQQQLQ QQQLDIQRKG MEMVTSATSS TPLPTPIPTS SVLTAAEKKA RNQALTQAQE QNQVASQVGT GQDIYEFHED GGEEPKPKTI SSVAPSAEDQ RPRLILTINK TQPSIKNISE MEQTIQQQQQ QQSEVISNTD PIGGDNSESC NTRKSRRLQE KEDRSTVDDI IEDVVRNTNT PTGTGPHLPK GAQTPPRRSG RNAQAKKTDA VQIINAVGRP RRSKDRKTIG EQTANLIEEV TASNATVAAS HLAPPEGAGV ESHVPQLDAK EVEPVSVVTP ISTPAPVSVA APVTVPVPAM VPVKPTMPQH PKKKAIAAAE IESYQAINSS IPSGGLPMHQ TAAPATQKIT GGVADAVSKA LVDPVTGVIT AGMPQGKEGN LPAATAAAPA NSSNEDGQAA PPPQLQHQQQ QQHPQQPPQQ QANLQINTTL IPSGLPNPIT ALGKSVQLET SAAALLNKPV SVLVKGNASQ VIQQQQPQIV APAKQPIILQ QNPLPTVLHH AQHTTVRPPQ PLKAHVLNRE KNIQQQLTPT KQAVAQPPQH APHSGHMLLT DTAGNQQLVQ PQIIARHLQQ QQHLQVNVPP PTAHSPHSPR IPSQQQQLGP GASISPQQQQ PQTVVIKQAA SAAQPQILHV VSSKASVVPQ PQQQQLPPTS STGPHLQLAK PNYSYAPTVL TPTLPAVQQQ QQQHLYKQNN QQKGAQIQMP PHGIIMPTHP GMLLQQKLPA HLQPQQHQLN PSPPPGKPNP VLHGLQSGQI MPGSVGSPPP VSAAVLKTAQ QQVNSVVPVA GIRTAIPNIS PQSQPRVSPL VLPPGISGVP PFDASLHDLG AYVSGRRTQS PPPAHQQASP ITPNDSTYRG VTASRDFMLY QHHLMRGGDY DDKMGSSPPL ELRRPGSGPP RTIAVPHSLQ SPQDRTAADS PQMAQVYVHN TRIPPAHFSE IASRGLYDSG ALQLEPPPAH RPTATISVVV PQQMPAVSSG SPFIGRDGSV QPGSHHHPGK AMDMQLDEMD RMSMIAAVVQ QQQEHLPPAL PAGMELASQQ APPAMAPPPG DSLVTLLQRY PVMWQGLLAL KTDQAAVQMH FVHGNPNVAR ASLPSLVETN TPLLRIAQRM RLEQTQLEGV AKKMQVDKEH CMLLALPCGR DHADVLQHSR NLQTGFITYL QQKMAAGIVN IPIPGSEQAA YVVHIFPSCD FANENLERAA PDLKNRVAEL AHLLIVIATV //