ID TSR1_DROME Reviewed; 814 AA. AC Q9VP47; B5RIG8; Q86PD4; Q95TR7; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 20-APR-2010, entry version 54. DE RecName: Full=Pre-rRNA-processing protein TSR1 homolog; GN ORFNames=CG7338; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Booth B., RA Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., RA Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., RA Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., RA Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.E.; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-814. RC STRAIN=Berkeley; TISSUE=Embryo; RX MEDLINE=22426066; PubMed=12537569; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-444, AND MASS RP SPECTROMETRY. RC TISSUE=Embryo; RX PubMed=18327897; DOI=10.1021/pr700696a; RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; RT "Phosphoproteome analysis of Drosophila melanogaster embryos."; RL J. Proteome Res. 7:1675-1682(2008). CC -!- FUNCTION: Required during maturation of the 40S ribosomal subunit CC in the nucleolus (By similarity). CC -!- INTERACTION: CC O01382:Ice; NbExp=1; IntAct=EBI-138303, EBI-91422; CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity). CC -!- SIMILARITY: Belongs to the BMS1/TSR1 family. TSR1 subfamily. CC -!- SEQUENCE CAUTION: CC Sequence=AAL13820.1; Type=Erroneous initiation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014296; AAF51709.1; -; Genomic_DNA. DR EMBL; BT003192; AAO24947.1; -; mRNA. DR EMBL; BT044092; ACH92157.1; -; mRNA. DR EMBL; AY058591; AAL13820.1; ALT_INIT; mRNA. DR RefSeq; NP_649304.1; -. DR UniGene; Dm.1034; -. DR IntAct; Q9VP47; 4. DR MINT; MINT-823454; -. DR STRING; Q9VP47; -. DR PRIDE; Q9VP47; -. DR Ensembl; FBtr0078342; FBpp0077998; FBgn0037073; Drosophila melanogaster. DR GeneID; 40360; -. DR KEGG; dme:Dmel_CG7338; -. DR NMPDR; fig|7227.3.peg.10898; -. DR UCSC; CG7338-RA; d. melanogaster. DR FlyBase; FBgn0037073; CG7338. DR eggNOG; inNOG04858; -. DR InParanoid; Q9VP47; -. DR OMA; GTSEYQA; -. DR OrthoDB; EOG944KSR; -. DR PhylomeDB; Q9VP47; -. DR NextBio; 818374; -. DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0042255; P:ribosome assembly; ISS:UniProtKB. DR InterPro; IPR012948; AARP2CN. DR InterPro; IPR007034; DUF663. DR Pfam; PF08142; AARP2CN; 1. DR Pfam; PF04950; DUF663; 1. DR SMART; SM00785; AARP2CN; 1. PE 1: Evidence at protein level; KW Complete proteome; Nucleus; Phosphoprotein; Ribosome biogenesis. FT CHAIN 1 814 Pre-rRNA-processing protein TSR1 homolog. FT /FTId=PRO_0000311280. FT COMPBIAS 401 443 Asp-rich. FT MOD_RES 444 444 Phosphothreonine. FT CONFLICT 570 570 E -> V (in Ref. 3; AAO24947). SQ SEQUENCE 814 AA; 93717 MW; 3C9299F0F65556A3 CRC64; MADHAFHRPG PLKQANKAHK TGRHRSKGAI DNAQKGKIGL RPISHKHKQQ QRKEQRRNQM NQLRKNKREE VLEQKRKLGG QNTAPFLVCL LPMHEQIDPM SALEILKSCD SELVVENSPS GIVYINLPRF KQRFAFVTPP VGRGNELIAL DYLKVCDTTL LLTTAAFGDD EIFDRWGQRI FNMMSAQGIP TPVVALMDLE SINPKRRPAA KQAAQKVISK LLPEEKIMQL DTASEALNVM RRIGGQKKRI LHNVANRPHL FGDVVEFKPG SDPSDDLGTL EVTGFLRGQS LNVNGLVHIP GLGDFQLSQV VAPPDPYKLD KSRDGENSEV RLLDRSDPSK RTSLQSENIP DPMDAEQTWP TEDEIAASQA ETKKMKLVKR VPKGYSEYQA AWIPDVEEVE DPDGKDDDDM SEDDDDDKED DNEDFMSCDN KSFEDEYEKR DSDTEEFQDT VSVASEAAIN DEKYDQQMDF QEERETLKKL QQARTDQLWP DEIDTPLDVP ARERFQKYRG LESFRTSPWD AKENLPADYA RIYQFQNFDR TKRRILNEAK EFEGVLPGLY VTLYVINVPE SRWNAFKSAQ LMDNIIVYGM LPHEHQMCVM NVVLQRMPDS EVPLKSKEQL IIQCGYRRFV VNPIYSQHTN GDKHKFERYF RPYETVCATF YAPIQFPPAP VLAFKVNPDS TLALVARGRL LSCNPDRIVL KRVVLSGHPM RINRKSASIR YMFFYKEDVE YFKPVKLRTK CGRLGHIKES LGTHGHMKCY FDGQLRSYDT AFMYLYKRVF PKWTYEECLV RTAEHERQHA SANRRSSQQV AMEE //