ID TOTM_DROME Reviewed; 131 AA. AC Q9VMR8; Q962D7; DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 2. DT 16-JAN-2019, entry version 100. DE RecName: Full=Protein Turandot M; DE Flags: Precursor; GN Name=TotM {ECO:0000312|EMBL:AAF52243.2}; ORFNames=CG14027; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK64525.1} RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DEVELOPMENTAL STAGE, RP AND INDUCTION. RC STRAIN=Canton-S {ECO:0000312|EMBL:AAK64525.1}; RC TISSUE=Embryo {ECO:0000269|PubMed:11409894}; RX PubMed=11409894; DOI=10.1006/bbrc.2001.5067; RA Ekengren S., Hultmark D.; RT "A family of Turandot-related genes in the humoral stress response of RT Drosophila."; RL Biochem. Biophys. Res. Commun. 284:998-1003(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000305} RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000305} RP FUNCTION. RX PubMed=16611243; DOI=10.1111/j.1365-2443.2006.00953.x; RA Brun S., Vidal S., Spellman P., Takahashi K., Tricoire H., RA Lemaitre B.; RT "The MAPKKK Mekk1 regulates the expression of Turandot stress genes in RT response to septic injury in Drosophila."; RL Genes Cells 11:397-407(2006). CC -!- FUNCTION: A humoral factor that may play a role in stress CC tolerance. Requires Mekk1 expression in the fat body to regulate CC response to septic injury and consequent immune response. CC {ECO:0000269|PubMed:11409894, ECO:0000269|PubMed:16611243}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11409894, CC ECO:0000305}. CC -!- DEVELOPMENTAL STAGE: Expressed at very low levels. CC {ECO:0000269|PubMed:11409894}. CC -!- INDUCTION: By a variety of stressful conditions including CC bacterial infection and heat shock. {ECO:0000269|PubMed:11409894}. CC -!- SIMILARITY: Belongs to the Turandot family. {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY035992; AAK64525.1; -; mRNA. DR EMBL; AE014134; AAF52243.2; -; Genomic_DNA. DR RefSeq; NP_001245887.1; NM_001258958.1. DR RefSeq; NP_523482.1; NM_078758.3. DR UniGene; Dm.1703; -. DR STRING; 7227.FBpp0078708; -. DR PaxDb; Q9VMR8; -. DR PRIDE; Q9VMR8; -. DR EnsemblMetazoa; FBtr0079073; FBpp0078708; FBgn0031701. DR EnsemblMetazoa; FBtr0307036; FBpp0297879; FBgn0031701. DR GeneID; 33764; -. DR KEGG; dme:Dmel_CG14027; -. DR UCSC; CG14027-RA; d. melanogaster. DR CTD; 33764; -. DR FlyBase; FBgn0031701; TotM. DR GeneTree; ENSGT00540000073707; -. DR OMA; TRYRNVD; -. DR OrthoDB; 1519974at2759; -. DR PhylomeDB; Q9VMR8; -. DR GenomeRNAi; 33764; -. DR PRO; PR:Q9VMR8; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0031701; Expressed in 14 organ(s), highest expression level in adult tagma (Drosophila). DR ExpressionAtlas; Q9VMR8; differential. DR Genevisible; Q9VMR8; DM. DR GO; GO:0005576; C:extracellular region; ISM:FlyBase. DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB. DR GO; GO:0034605; P:cellular response to heat; IEP:FlyBase. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEP:FlyBase. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0009617; P:response to bacterium; IEP:FlyBase. DR GO; GO:0009408; P:response to heat; IDA:UniProtKB. DR InterPro; IPR010825; Turandot. DR Pfam; PF07240; Turandot; 1. PE 2: Evidence at transcript level; KW Complete proteome; Immunity; Innate immunity; Reference proteome; KW Secreted; Signal. FT SIGNAL 1 23 {ECO:0000255}. FT CHAIN 24 131 Protein Turandot M. FT /FTId=PRO_0000354996. SQ SEQUENCE 131 AA; 14967 MW; 26B14C3BD2F7636B CRC64; MNPTIYLSCL MVFSVFLLGK VNAENEDEFV TEKQRLFSVY GDSSVDEATK YRNIDSLVTF YDKYFTRLQL KPDLNTRAHD LLRRYKEENA RVVLVDGTPA QGGFWLPLVK LLIVQLGVEI ASEGVKRAIE S //