ID Q9VMR2_DROME Unreviewed; 580 AA. AC Q9VMR2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 15-FEB-2017, entry version 149. DE SubName: Full=LP04777p {ECO:0000313|EMBL:AAZ41777.1}; DE SubName: Full=Midline, isoform A {ECO:0000313|EMBL:AAF52250.1}; DE SubName: Full=Midline, isoform B {ECO:0000313|EMBL:AGB92632.1}; GN Name=mid {ECO:0000313|EMBL:AAF52250.1, GN ECO:0000313|FlyBase:FBgn0261963}; GN ORFNames=CG6634 {ECO:0000313|EMBL:AAZ41777.1, GN ECO:0000313|FlyBase:FBgn0261963}, Dmel_CG6634 GN {ECO:0000313|EMBL:AAF52250.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAZ41777.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAZ41777.1}; RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., RA Park S., Wan K., Yu C., Celniker S.; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF52250.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF52250.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF52250.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF52250.1} RP NUCLEOTIDE SEQUENCE. RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00201, ECO:0000256|SAAS:SAAS00030481}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF52250.1; -; Genomic_DNA. DR EMBL; BT023769; AAZ41777.1; -; mRNA. DR EMBL; AE014134; AGB92632.1; -; Genomic_DNA. DR RefSeq; NP_001260096.1; NM_001273167.2. DR RefSeq; NP_608927.2; NM_135083.4. DR UniGene; Dm.6038; -. DR STRING; 7227.FBpp0078726; -. DR EnsemblMetazoa; FBtr0079093; FBpp0078726; FBgn0261963. DR EnsemblMetazoa; FBtr0310358; FBpp0302039; FBgn0261963. DR GeneID; 33770; -. DR KEGG; dme:Dmel_CG6634; -. DR UCSC; CG6634-RA; d. melanogaster. DR CTD; 33770; -. DR FlyBase; FBgn0261963; mid. DR eggNOG; KOG3586; Eukaryota. DR eggNOG; ENOG410Y98J; LUCA. DR GeneTree; ENSGT00760000118897; -. DR OMA; GSCNCDE; -. DR OrthoDB; EOG091G0I8R; -. DR ChiTaRS; mid; fly. DR GenomeRNAi; 33770; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0261963; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:FlyBase. DR GO; GO:0001226; F:RNA polymerase II transcription corepressor binding; IPI:FlyBase. DR GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:FlyBase. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0007409; P:axonogenesis; IMP:FlyBase. DR GO; GO:0042684; P:cardioblast cell fate commitment; IMP:FlyBase. DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase. DR GO; GO:0030381; P:chorion-containing eggshell pattern formation; IMP:FlyBase. DR GO; GO:0035050; P:embryonic heart tube development; IMP:FlyBase. DR GO; GO:0097156; P:fasciculation of motor neuron axon; IMP:FlyBase. DR GO; GO:0007402; P:ganglion mother cell fate determination; IMP:FlyBase. DR GO; GO:0008406; P:gonad development; IMP:FlyBase. DR GO; GO:0007507; P:heart development; IMP:FlyBase. DR GO; GO:0003015; P:heart process; IDA:FlyBase. DR GO; GO:0035223; P:leg disc pattern formation; IGI:FlyBase. DR GO; GO:0010629; P:negative regulation of gene expression; IMP:FlyBase. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:FlyBase. DR GO; GO:0014019; P:neuroblast development; IMP:FlyBase. DR GO; GO:0014018; P:neuroblast fate specification; IMP:FlyBase. DR GO; GO:0048665; P:neuron fate specification; IMP:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase. DR GO; GO:0051890; P:regulation of cardioblast differentiation; IMP:FlyBase. DR GO; GO:0042659; P:regulation of cell fate specification; IMP:FlyBase. DR GO; GO:0051960; P:regulation of nervous system development; IMP:FlyBase. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR CDD; cd00182; TBOX; 1. DR Gene3D; 2.60.40.820; -; 1. DR InterPro; IPR008967; p53-like_TF_DNA-bd. DR InterPro; IPR001699; TF_T-box. DR InterPro; IPR018186; TF_T-box_CS. DR PANTHER; PTHR11267; PTHR11267; 1. DR Pfam; PF00907; T-box; 1. DR PRINTS; PR00937; TBOX. DR SMART; SM00425; TBOX; 1. DR SUPFAM; SSF49417; SSF49417; 1. DR PROSITE; PS01283; TBOX_1; 1. DR PROSITE; PS50252; TBOX_3; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00201, KW ECO:0000256|SAAS:SAAS00030479}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00201, KW ECO:0000256|SAAS:SAAS00030484}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transcription {ECO:0000256|SAAS:SAAS00030480}; KW Transcription regulation {ECO:0000256|SAAS:SAAS00030485}. SQ SEQUENCE 580 AA; 62943 MW; DBE6E3C7C6DA621C CRC64; MLVGSHPYLC NGVPAAPAAP NASGQTTTTA SKSAAGSATD FSIAAIMARE DASSRESSIR SASPISVEDE VDVDVVDCSD AEEPPTKARR LNHHQHHQHH QHHHNNNNNN NNNNVAHKSR NSGGAVAQTA SAESQLNTSS TSSQGRCSTP PQSPGTEDSE ERLTPEPVQK APKIVGSCNC DDLKPVQCHL ETKELWDRFH DLGTEMIITK TGRRMFPTVR VSFSGPLRQI QPADRYAVLM DIIPMDSKRY RYAYHRSAWL VAGKADPAPP ARLYAHPDSP FSCEALRKQV ISFEKVKLTN NEMDKNGQIV LNSMHRYQPR IHLVRLSHGQ SIPSNPKELQ DLDHKTYVFP ETVFTAVTAY QNQLITKLKI DSNPFAKGFR DSSRLTDFDR DPMEALLLEQ QLRSPLRLFP DPLMQQFAAQ GDPSSMALFE KARQHLQMFG GNSPYAQLMM PQMYQAAAAA AGPPPPPPGL GAFHMFQQQW PQLTAGFLAS ANQQAAAAQA AAQAQAQAQA AAAAMAANRT PPPPPTASTP SSTSSGSPSP DMRPRQYQRF SPYQLPGGQG PPSSAAGSPP AVNASRSPAH //