ID Q9VMR2_DROME Unreviewed; 580 AA. AC Q9VMR2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 24-JUL-2013, entry version 112. DE SubName: Full=LP04777p; DE SubName: Full=Midline, isoform A; DE SubName: Full=Midline, isoform B; GN Name=mid; ORFNames=CG6634, Dmel_CG6634; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE. RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] RP NUCLEOTIDE SEQUENCE. RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] RP NUCLEOTIDE SEQUENCE. RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley; RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., RA Park S., Wan K., Yu C., Celniker S.; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE. RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] RP NUCLEOTIDE SEQUENCE. RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Contains 1 T-box DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF52250.1; -; Genomic_DNA. DR EMBL; BT023769; AAZ41777.1; -; mRNA. DR EMBL; AE014134; AGB92632.1; -; Genomic_DNA. DR RefSeq; NP_001260096.1; NM_001273167.1. DR RefSeq; NP_608927.2; NM_135083.3. DR UniGene; Dm.6038; -. DR EnsemblMetazoa; FBtr0079093; FBpp0078726; FBgn0261963. DR EnsemblMetazoa; FBtr0310358; FBpp0302039; FBgn0261963. DR GeneID; 33770; -. DR KEGG; dme:Dmel_CG6634; -. DR UCSC; CG6634-RA; d. melanogaster. DR CTD; 33770; -. DR FlyBase; FBgn0261963; mid. DR GeneTree; ENSGT00710000106249; -. DR InParanoid; Q9VMR2; -. DR OMA; NVANHIN; -. DR ChiTaRS; mid; drosophila. DR GenomeRNAi; 33770; -. DR NextBio; 785168; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:FlyBase. DR GO; GO:0001227; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IMP:FlyBase. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0042684; P:cardioblast cell fate commitment; IMP:FlyBase. DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase. DR GO; GO:0035050; P:embryonic heart tube development; IMP:FlyBase. DR GO; GO:0007402; P:ganglion mother cell fate determination; IMP:FlyBase. DR GO; GO:0003015; P:heart process; IDA:FlyBase. DR GO; GO:0035223; P:leg disc pattern formation; IGI:FlyBase. DR GO; GO:0014019; P:neuroblast development; IMP:FlyBase. DR GO; GO:0014018; P:neuroblast fate specification; IMP:FlyBase. DR GO; GO:0048665; P:neuron fate specification; IMP:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase. DR GO; GO:0051890; P:regulation of cardioblast differentiation; IMP:FlyBase. DR GO; GO:0042659; P:regulation of cell fate specification; IGI:FlyBase. DR GO; GO:0051960; P:regulation of nervous system development; IMP:FlyBase. DR Gene3D; 2.60.40.820; -; 1. DR InterPro; IPR008967; p53-like_TF_DNA-bd. DR InterPro; IPR001699; TF_T-box. DR InterPro; IPR018186; TF_T-box_CS. DR PANTHER; PTHR11267; PTHR11267; 1. DR Pfam; PF00907; T-box; 1. DR PRINTS; PR00937; TBOX. DR SMART; SM00425; TBOX; 1. DR SUPFAM; SSF49417; P53_like_DNA_bnd; 1. DR PROSITE; PS01283; TBOX_1; 1. DR PROSITE; PS50252; TBOX_3; 1. PE 2: Evidence at transcript level; KW Complete proteome; DNA-binding; Nucleus; Reference proteome; KW Transcription; Transcription regulation. SQ SEQUENCE 580 AA; 62943 MW; DBE6E3C7C6DA621C CRC64; MLVGSHPYLC NGVPAAPAAP NASGQTTTTA SKSAAGSATD FSIAAIMARE DASSRESSIR SASPISVEDE VDVDVVDCSD AEEPPTKARR LNHHQHHQHH QHHHNNNNNN NNNNVAHKSR NSGGAVAQTA SAESQLNTSS TSSQGRCSTP PQSPGTEDSE ERLTPEPVQK APKIVGSCNC DDLKPVQCHL ETKELWDRFH DLGTEMIITK TGRRMFPTVR VSFSGPLRQI QPADRYAVLM DIIPMDSKRY RYAYHRSAWL VAGKADPAPP ARLYAHPDSP FSCEALRKQV ISFEKVKLTN NEMDKNGQIV LNSMHRYQPR IHLVRLSHGQ SIPSNPKELQ DLDHKTYVFP ETVFTAVTAY QNQLITKLKI DSNPFAKGFR DSSRLTDFDR DPMEALLLEQ QLRSPLRLFP DPLMQQFAAQ GDPSSMALFE KARQHLQMFG GNSPYAQLMM PQMYQAAAAA AGPPPPPPGL GAFHMFQQQW PQLTAGFLAS ANQQAAAAQA AAQAQAQAQA AAAAMAANRT PPPPPTASTP SSTSSGSPSP DMRPRQYQRF SPYQLPGGQG PPSSAAGSPP AVNASRSPAH //