ID U2QL1_DROME Reviewed; 306 AA. AC Q9VM35; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 03-JUL-2019, entry version 133. DE RecName: Full=Ubiquitin-conjugating enzyme E2Q-like protein CG4502; DE EC=2.3.2.23; DE AltName: Full=E2Q-like ubiquitin-conjugating enzyme CG4502; GN ORFNames=CG4502; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). CC -!- FUNCTION: Catalyzes the covalent attachment of ubiquitin to other CC proteins. {ECO:0000255|PROSITE-ProRule:PRU00388}. CC -!- CATALYTIC ACTIVITY: CC Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine CC + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- CC activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- CC conjugating enzyme]-L-cysteine.; EC=2.3.2.23; CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00388}; CC -!- PATHWAY: Protein modification; protein ubiquitination. CC {ECO:0000255|PROSITE-ProRule:PRU00388}. CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. CC {ECO:0000255|PROSITE-ProRule:PRU00388}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF52492.1; -; Genomic_DNA. DR EMBL; AE014134; AAF52493.1; -; Genomic_DNA. DR EMBL; AY060422; AAL25461.1; -; mRNA. DR RefSeq; NP_609103.1; NM_135259.3. DR RefSeq; NP_723260.1; NM_164741.2. DR SMR; Q9VM35; -. DR BioGrid; 60148; 2. DR STRING; 7227.FBpp0079044; -. DR PaxDb; Q9VM35; -. DR PRIDE; Q9VM35; -. DR EnsemblMetazoa; FBtr0079416; FBpp0079044; FBgn0031896. DR EnsemblMetazoa; FBtr0079417; FBpp0079045; FBgn0031896. DR GeneID; 34002; -. DR KEGG; dme:Dmel_CG4502; -. DR UCSC; CG4502-RA; d. melanogaster. DR FlyBase; FBgn0031896; CG4502. DR eggNOG; KOG0897; Eukaryota. DR eggNOG; ENOG410XRET; LUCA. DR GeneTree; ENSGT00940000161612; -. DR InParanoid; Q9VM35; -. DR KO; K10582; -. DR OMA; HKVAPTT; -. DR OrthoDB; 1214134at2759; -. DR PhylomeDB; Q9VM35; -. DR SignaLink; Q9VM35; -. DR UniPathway; UPA00143; -. DR ChiTaRS; CG4502; fly. DR GenomeRNAi; 34002; -. DR PRO; PR:Q9VM35; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0031896; Expressed in 37 organ(s), highest expression level in adult organism. DR Genevisible; Q9VM35; DM. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central. DR CDD; cd00195; UBCc; 1. DR Gene3D; 3.10.110.10; -; 1. DR InterPro; IPR000608; UBQ-conjugat_E2. DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD. DR Pfam; PF00179; UQ_con; 1. DR SUPFAM; SSF54495; SSF54495; 1. DR PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1. PE 2: Evidence at transcript level; KW ATP-binding; Complete proteome; Nucleotide-binding; KW Reference proteome; Transferase; Ubl conjugation pathway. FT CHAIN 1 306 Ubiquitin-conjugating enzyme E2Q-like FT protein CG4502. FT /FTId=PRO_0000335813. FT COMPBIAS 22 41 Poly-Asn. FT COMPBIAS 53 66 Poly-Asn. FT ACT_SITE 234 234 Glycyl thioester intermediate. FT {ECO:0000255|PROSITE-ProRule:PRU00388}. SQ SEQUENCE 306 AA; 33670 MW; 75897876D46A813A CRC64; MSSRSKERVV TAFRKIFHKS SNNNNNNNNN HNNNINNNNN NDKVDGATGS SPNINNNNNN NNNNNNHDGA AAPSSAGGVA VAGGAVGSSG SSGAAKNAVV RMAAEQAVWD SPGKRRRQDH KVAPTTERQL VAAPDHTIRT RRLMKEYREM ERLQAKNDAV FTVELVNDSL FEWHVRLHVI DPDSPLARDM AEMGVPAILL HLSFPDNFPF APPFMRVVEP HIEKGYVMEG GAICMELLTP RGWASAYTVE AVIMQFAASV VKGQGRIARK PKSTKEFTRR QAEESFRSLV KTHEKYGWVT PALSDG //