ID Q9VJA1_DROME Unreviewed; 633 AA. AC Q9VJA1; Q8WTC3; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 2. DT 22-FEB-2023, entry version 189. DE SubName: Full=Suppressor of cytokine signaling SOCS36E {ECO:0000313|EMBL:AAL30823.1}; DE SubName: Full=Suppressor of cytokine signaling at 36E, isoform A {ECO:0000313|EMBL:AAF53652.2}; DE SubName: Full=Suppressor of cytokine signaling at 36E, isoform C {ECO:0000313|EMBL:AGB93069.1}; GN Name=Socs36E {ECO:0000313|EMBL:AAF53652.2, GN ECO:0000313|FlyBase:FBgn0041184}; GN Synonyms=anon-EST:Liang-2.2 {ECO:0000313|EMBL:AAF53652.2}, clone 2.2 GN {ECO:0000313|EMBL:AAF53652.2}, Dmel\CG15154 GN {ECO:0000313|EMBL:AAF53652.2}, dmSocs36E GN {ECO:0000313|EMBL:AAF53652.2}, dSOCS {ECO:0000313|EMBL:AAF53652.2}, GN SCOS36E {ECO:0000313|EMBL:AAF53652.2}, SOCS GN {ECO:0000313|EMBL:AAF53652.2}, Socs {ECO:0000313|EMBL:AAF53652.2}, GN SOCS36 {ECO:0000313|EMBL:AAF53652.2}, SOCS36E GN {ECO:0000313|EMBL:AAF53652.2}, SocS36E {ECO:0000313|EMBL:AAF53652.2}, GN Socs36e {ECO:0000313|EMBL:AAF53652.2}, socs36E GN {ECO:0000313|EMBL:AAF53652.2}, socs36e {ECO:0000313|EMBL:AAF53652.2}, GN socs60E1 {ECO:0000313|EMBL:AAF53652.2}; GN ORFNames=CG15154 {ECO:0000313|EMBL:AAF53652.2, GN ECO:0000313|FlyBase:FBgn0041184}, Dmel_CG15154 GN {ECO:0000313|EMBL:AAF53652.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAL30823.1} RP NUCLEOTIDE SEQUENCE. RA Rennebeck G.; RT "A Drosophila homologue of suppressor of cytokine signaling (SOCS) responds RT to JAK pathway activity."; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [6] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF53652.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAF53652.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AAF53652.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AAF53652.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AAF53652.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [14] {ECO:0000313|EMBL:AAF53652.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AAF53652.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53652.2; -; Genomic_DNA. DR EMBL; AF435838; AAL30823.1; -; mRNA. DR EMBL; AE014134; AGB93069.1; -; Genomic_DNA. DR RefSeq; NP_001260534.1; NM_001273605.2. DR RefSeq; NP_724096.1; NM_165243.3. DR STRING; 7227.FBpp0080593; -. DR EnsemblMetazoa; FBtr0081040; FBpp0080593; FBgn0041184. DR EnsemblMetazoa; FBtr0329927; FBpp0302959; FBgn0041184. DR GeneID; 35085; -. DR KEGG; dme:Dmel_CG15154; -. DR UCSC; CG15154-RA; d. melanogaster. DR AGR; FB:FBgn0041184; -. DR CTD; 35085; -. DR FlyBase; FBgn0041184; Socs36E. DR VEuPathDB; VectorBase:FBgn0041184; -. DR GeneTree; ENSGT00940000173657; -. DR HOGENOM; CLU_380487_0_0_1; -. DR OMA; FEPCLTM; -. DR OrthoDB; 5362214at2759; -. DR BioGRID-ORCS; 35085; 0 hits in 1 CRISPR screen. DR ChiTaRS; ninaC; fly. DR GenomeRNAi; 35085; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0041184; Expressed in wing disc and 46 other tissues. DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central. DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central. DR GO; GO:0043697; P:cell dedifferentiation; IGI:FlyBase. DR GO; GO:0030718; P:germ-line stem cell population maintenance; IMP:FlyBase. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0007616; P:long-term memory; IMP:FlyBase. DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW. DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central. DR Gene3D; 3.30.505.10; SH2 domain; 1. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR001496; SOCS_box. DR InterPro; IPR036036; SOCS_box-like_dom_sf. DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1. DR PANTHER; PTHR10155:SF0; SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D; 1. DR Pfam; PF00017; SH2; 1. DR Pfam; PF07525; SOCS_box; 1. DR SMART; SM00252; SH2; 1. DR SMART; SM00253; SOCS; 1. DR SMART; SM00969; SOCS_box; 1. DR SUPFAM; SSF55550; SH2 domain; 1. DR SUPFAM; SSF158235; SOCS box-like; 1. DR PROSITE; PS50001; SH2; 1. DR PROSITE; PS50225; SOCS; 1. PE 2: Evidence at transcript level; KW Growth regulation {ECO:0000256|ARBA:ARBA00022604}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}; KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}. FT DOMAIN 474..569 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT DOMAIN 565..613 FT /note="SOCS box" FT /evidence="ECO:0000259|PROSITE:PS50225" FT REGION 1..29 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 146..166 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 208..233 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 252..277 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 343..372 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 8..29 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 210..225 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 353..372 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 633 AA; 68903 MW; E0B485A34D44F9DB CRC64; MGHHLSKFSA RANSQEKRNP TASSSPREAA ALVETISLDE EELQVEEILT EATVSAATSP AEVRQIIIKI QLAKMENGNP VAAGQVESFA EVVEQEEEQQ RQCADGATDD DAAALSADSL NANGQIVNVT LEGGYGEVGV VTNRTAGSSP EAAKTERQPV NNNGLAGSVG AAISTLQLHD NHGGNANCPL EADDDDDLDE SLLRRRRSNS NSRSNIHHHH HHHQQQQQQQ HEAEVVEYCE VLESLPVSNM LSAGTQHSSK PVSRSNNSNS CCRSRSSKAL SMGAATSSAS GSASTSVSTS TSSKRRCCKC KCRDAIRGLR DMLPSSSSSV SNKKDAAAVV AMVPRKSRTA DRRSTPPTLG TSSGGSQRRM QSQRIRNSVA VPDASHHHHQ LIIRITSPGF VVESPNGGRV TVVTEPAPQS PQTPPRPRPL ATVAPAGGAG HAGIGAARNM TVHSQIDFMH CLVPDLEKIT NSSFYWGKMD RYEAEHLLEG KPEGTFLLRD SAQEEFLFSV TFRKYGRSLH ARIEQSGHKF SFDCHDPCVF TAPTVTGLLE HYKDPACVMF FEPCLTIPLH RRQTFSLQQL SRATIVSNTS YDGINQMELP GRLKSYLKEY HYKQKLRVKP IDQNTPMPYY GNV //