ID Q9VIH6_DROME Unreviewed; 592 AA. AC Q9VIH6; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 2. DT 29-MAY-2024, entry version 142. DE SubName: Full=Skywalker, isoform C {ECO:0000313|EMBL:AAF53943.2}; GN Name=sky {ECO:0000313|EMBL:AAF53943.2, GN ECO:0000313|FlyBase:FBgn0032901}; GN Synonyms=anon-WO0118547.455 {ECO:0000313|EMBL:AAF53943.2}, CG14399 GN {ECO:0000313|EMBL:AAF53943.2}, CG9340 {ECO:0000313|EMBL:AAF53943.2}, GN Dmel\CG9339 {ECO:0000313|EMBL:AAF53943.2}, Sky GN {ECO:0000313|EMBL:AAF53943.2}; GN ORFNames=CG9339 {ECO:0000313|EMBL:AAF53943.2, GN ECO:0000313|FlyBase:FBgn0032901}, Dmel_CG9339 GN {ECO:0000313|EMBL:AAF53943.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53943.2; -; Genomic_DNA. DR RefSeq; NP_724304.1; NM_165352.4. DR AlphaFoldDB; Q9VIH6; -. DR SMR; Q9VIH6; -. DR IntAct; Q9VIH6; 1. DR DNASU; 35359; -. DR EnsemblMetazoa; FBtr0081444; FBpp0080973; FBgn0032901. DR GeneID; 35359; -. DR UCSC; CG9339-RC; d. melanogaster. DR AGR; FB:FBgn0032901; -. DR CTD; 35359; -. DR FlyBase; FBgn0032901; sky. DR VEuPathDB; VectorBase:FBgn0032901; -. DR GeneTree; ENSGT00410000025739; -. DR OrthoDB; 5396136at2759; -. DR PhylomeDB; Q9VIH6; -. DR BioGRID-ORCS; 35359; 0 hits in 1 CRISPR screen. DR ChiTaRS; sky; fly. DR GenomeRNAi; 35359; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0032901; Expressed in brain and 11 other cell types or tissues. DR ExpressionAtlas; Q9VIH6; baseline and differential. DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0043195; C:terminal bouton; IDA:FlyBase. DR GO; GO:0005096; F:GTPase activator activity; ISS:FlyBase. DR GO; GO:0007268; P:chemical synaptic transmission; IMP:FlyBase. DR GO; GO:1903422; P:negative regulation of synaptic vesicle recycling; IMP:FlyBase. DR GO; GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase. DR GO; GO:0043087; P:regulation of GTPase activity; ISS:FlyBase. DR GO; GO:0006979; P:response to oxidative stress; IEA:TreeGrafter. DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1. DR InterPro; IPR000195; Rab-GAP-TBC_dom. DR InterPro; IPR035969; Rab-GAP_TBC_sf. DR InterPro; IPR006571; TLDc_dom. DR PANTHER; PTHR23354:SF129; GTPASE-ACTIVATING PROTEIN SKYWALKER; 1. DR PANTHER; PTHR23354; NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED; 1. DR Pfam; PF00566; RabGAP-TBC; 1. DR Pfam; PF07534; TLD; 1. DR SMART; SM00164; TBC; 1. DR SMART; SM00584; TLDc; 1. DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 1. DR PROSITE; PS50086; TBC_RABGAP; 1. DR PROSITE; PS51886; TLDC; 1. PE 4: Predicted; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Synapse {ECO:0000256|ARBA:ARBA00023018}. FT DOMAIN 89..280 FT /note="Rab-GAP TBC" FT /evidence="ECO:0000259|PROSITE:PS50086" FT DOMAIN 413..590 FT /note="TLDc" FT /evidence="ECO:0000259|PROSITE:PS51886" SQ SEQUENCE 592 AA; 67979 MW; 123C8A8C291804D1 CRC64; MVGKVLGIKD LEQFSSRRSS VYVDPECDKF FELPLFIAAS SNDITTKCQC FQFSPGKEPA LRSYTEIQQL LQQGKKRDVK NILRENSWPI NSPIRAQLWP MLCGQHQTKQ QMLDGFYWEM VHQVFGTTEL SEKPIMLPAF VDATHCLPYH LTSTGRAVAD RIVNVLGYDC PDITYSPVLY PITSILLHFM SEEEAYICLA GLVGSKEKVF INQTKLQHEV TWKTVMQIAK KHTKSATSYF QRICPGLKLE RIFMDWCWWI LAGLPFQHLV RIMDCYFHEG IKVLYRVALV ILNLFHKECQ SNNEWSPDNI KNDIGNALIK FCKKIPVSPA KLLHAAFSIR GLSTQYISRI FIKTEMLLKS RSVLTSGSKQ LIKSRSSDNL PTSQSQVNIQ MMSHTLTIRE HFGLPGTKNF IKTWTDRQFL FTLWSWLPVR ITMYQPVLLY TTEEHGCSLT TFYVRVEQHE PTLLMIKTCN NEVFGAYCSS RWFERNVKDD KGQRQAYFGT GETFLFSLYP ERAKYPWVGI EGDKDLGHSS ELFMAADSKM ITIGGGEGQA IWMDENIRFG KTDSCKTFNN PPLCPSGDFE IRVLEVYGFV GI //