ID Q9VIH6_DROME Unreviewed; 592 AA. AC Q9VIH6; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 2. DT 05-JUL-2017, entry version 106. DE SubName: Full=Skywalker, isoform C {ECO:0000313|EMBL:AAF53943.2}; GN Name=sky {ECO:0000313|EMBL:AAF53943.2, GN ECO:0000313|FlyBase:FBgn0032901}; GN Synonyms=anon-WO0118547.455 {ECO:0000313|EMBL:AAF53943.2}, Dmel\CG9339 GN {ECO:0000313|EMBL:AAF53943.2}; GN ORFNames=CG14399 {ECO:0000313|EMBL:AAF53943.2}, CG9339 GN {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|FlyBase:FBgn0032901}, CG9340 GN {ECO:0000313|EMBL:AAF53943.2}, Dmel_CG9339 GN {ECO:0000313|EMBL:AAF53943.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AAF53943.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53943.2; -; Genomic_DNA. DR RefSeq; NP_724304.1; NM_165352.4. DR UniGene; Dm.2151; -. DR ProteinModelPortal; Q9VIH6; -. DR SMR; Q9VIH6; -. DR IntAct; Q9VIH6; 1. DR PRIDE; Q9VIH6; -. DR EnsemblMetazoa; FBtr0081444; FBpp0080973; FBgn0032901. DR GeneID; 35359; -. DR UCSC; CG9339-RC; d. melanogaster. DR CTD; 35359; -. DR FlyBase; FBgn0032901; sky. DR GeneTree; ENSGT00410000025739; -. DR InParanoid; Q9VIH6; -. DR OMA; RQGYWAK; -. DR OrthoDB; EOG091G03K9; -. DR PhylomeDB; Q9VIH6; -. DR Reactome; R-DME-8854214; TBC/RABGAPs. DR ChiTaRS; sky; fly. DR GenomeRNAi; 35359; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0032901; -. DR Genevisible; Q9VIH6; DM. DR GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase. DR GO; GO:0043195; C:terminal bouton; IDA:FlyBase. DR GO; GO:0005096; F:GTPase activator activity; ISS:FlyBase. DR GO; GO:0007268; P:chemical synaptic transmission; IMP:FlyBase. DR GO; GO:1903422; P:negative regulation of synaptic vesicle recycling; IMP:FlyBase. DR GO; GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase. DR GO; GO:0043087; P:regulation of GTPase activity; ISS:FlyBase. DR InterPro; IPR000195; Rab-GTPase-TBC_dom. DR InterPro; IPR006571; TLDc_dom. DR Pfam; PF00566; RabGAP-TBC; 1. DR Pfam; PF07534; TLD; 1. DR SMART; SM00164; TBC; 1. DR SMART; SM00584; TLDc; 1. DR SUPFAM; SSF47923; SSF47923; 1. DR PROSITE; PS50086; TBC_RABGAP; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 89 280 Rab-GAP TBC. {ECO:0000259|PROSITE: FT PS50086}. SQ SEQUENCE 592 AA; 67979 MW; 123C8A8C291804D1 CRC64; MVGKVLGIKD LEQFSSRRSS VYVDPECDKF FELPLFIAAS SNDITTKCQC FQFSPGKEPA LRSYTEIQQL LQQGKKRDVK NILRENSWPI NSPIRAQLWP MLCGQHQTKQ QMLDGFYWEM VHQVFGTTEL SEKPIMLPAF VDATHCLPYH LTSTGRAVAD RIVNVLGYDC PDITYSPVLY PITSILLHFM SEEEAYICLA GLVGSKEKVF INQTKLQHEV TWKTVMQIAK KHTKSATSYF QRICPGLKLE RIFMDWCWWI LAGLPFQHLV RIMDCYFHEG IKVLYRVALV ILNLFHKECQ SNNEWSPDNI KNDIGNALIK FCKKIPVSPA KLLHAAFSIR GLSTQYISRI FIKTEMLLKS RSVLTSGSKQ LIKSRSSDNL PTSQSQVNIQ MMSHTLTIRE HFGLPGTKNF IKTWTDRQFL FTLWSWLPVR ITMYQPVLLY TTEEHGCSLT TFYVRVEQHE PTLLMIKTCN NEVFGAYCSS RWFERNVKDD KGQRQAYFGT GETFLFSLYP ERAKYPWVGI EGDKDLGHSS ELFMAADSKM ITIGGGEGQA IWMDENIRFG KTDSCKTFNN PPLCPSGDFE IRVLEVYGFV GI //