ID Q9VH01_DROME Unreviewed; 4876 AA. AC Q9VH01; Q8MUM9; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 3. DT 13-NOV-2019, entry version 171. DE SubName: Full=BIR repeat containing ubiquitin-conjugating enzyme, isoform A {ECO:0000313|EMBL:AAF54520.3}; DE SubName: Full=BIR-containing ubiquitin-conjugating enzyme {ECO:0000313|EMBL:AAM77747.1}; GN Name=Bruce {ECO:0000313|EMBL:AAF54520.3, GN ECO:0000313|FlyBase:FBgn0266717}; GN Synonyms=BRUCE {ECO:0000313|EMBL:AAF54520.3}, bruce GN {ECO:0000313|EMBL:AAF54520.3}, dBRUCE {ECO:0000313|EMBL:AAF54520.3}, GN dBruce {ECO:0000313|EMBL:AAF54520.3}, dbruce GN {ECO:0000313|EMBL:AAF54520.3}, Dmel\CG6303 GN {ECO:0000313|EMBL:AAF54520.3}, mod86 {ECO:0000313|EMBL:AAF54520.3}; GN ORFNames=CG6303 {ECO:0000313|EMBL:AAF54520.3, GN ECO:0000313|FlyBase:FBgn0266717}, Dmel_CG6303 GN {ECO:0000313|EMBL:AAF54520.3}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAM77747.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12121627; DOI=10.1016/S0960-9822(02)00935-1; RA Vernooy S.Y., Chow V., Su J., Verbrugghe K., Yang J., Cole S., RA Olson M.R., Hay B.A.; RT "Drosophila Bruce can potently suppress Rpr- and Grim-dependent but RT not Hid-dependent cell death."; RL Curr. Biol. 12:1164-1168(2002). RN [3] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [6] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF54520.3} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF54520.3} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF54520.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF54520.3} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAF54520.3} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAF54520.3} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- INTERACTION: CC Q6GKZ1:klhl10; NbExp=2; IntAct=EBI-2509194, EBI-15659303; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF54520.3; -; Genomic_DNA. DR EMBL; AF517634; AAM77747.1; -; mRNA. DR RefSeq; NP_649995.2; NM_141738.5. DR SMR; Q9VH01; -. DR DIP; DIP-29548N; -. DR IntAct; Q9VH01; 5. DR MEROPS; I32.006; -. DR EnsemblMetazoa; FBtr0082239; FBpp0081717; FBgn0266717. DR GeneID; 41260; -. DR UCSC; CG6303-RA; d. melanogaster. DR CTD; 41260; -. DR FlyBase; FBgn0266717; Bruce. DR eggNOG; KOG0895; Eukaryota. DR eggNOG; KOG1101; Eukaryota. DR eggNOG; ENOG410XP8C; LUCA. DR GeneTree; ENSGT00940000156126; -. DR GenomeRNAi; 41260; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0266717; Expressed in 32 organ(s), highest expression level in oocyte. DR GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IDA:FlyBase. DR GO; GO:0006915; P:apoptotic process; IEA:InterPro. DR GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase. DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:FlyBase. DR GO; GO:0016242; P:negative regulation of macroautophagy; IMP:FlyBase. DR GO; GO:0045849; P:negative regulation of nurse cell apoptotic process; IMP:FlyBase. DR GO; GO:0048477; P:oogenesis; IMP:FlyBase. DR GO; GO:0012501; P:programmed cell death; IGI:FlyBase. DR GO; GO:0000209; P:protein polyubiquitination; IMP:FlyBase. DR GO; GO:0032465; P:regulation of cytokinesis; IEA:InterPro. DR GO; GO:0007286; P:spermatid development; IMP:FlyBase. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:FlyBase. DR CDD; cd00022; BIR; 1. DR CDD; cd00195; UBCc; 1. DR Gene3D; 3.10.110.10; -; 1. DR InterPro; IPR001370; BIR_rpt. DR InterPro; IPR022103; BIRC6. DR InterPro; IPR000608; UBQ-conjugat_E2. DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD. DR Pfam; PF00653; BIR; 1. DR Pfam; PF12356; BIRC6; 1. DR Pfam; PF00179; UQ_con; 1. DR SMART; SM00238; BIR; 1. DR SUPFAM; SSF54495; SSF54495; 1. DR PROSITE; PS50143; BIR_REPEAT_2; 1. DR PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q9VH01}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 4535 4663 UBIQUITIN_CONJUGAT_2. FT {ECO:0000259|PROSITE:PS50127}. FT REGION 502 527 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 645 666 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 2238 2300 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 2874 2904 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 3851 3870 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 4202 4257 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 4829 4857 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COILED 1558 1585 {ECO:0000256|SAM:Coils}. FT COILED 1606 1626 {ECO:0000256|SAM:Coils}. FT COMPBIAS 2242 2294 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 2882 2898 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 4202 4248 Polar. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 4876 AA; 539214 MW; DD858A2584BB3A73 CRC64; MATEQHHQQR VLKQDGYLDL GDCNSAPSRP FEMRNVVYHP QLNVLLLFDN GSTVKVLDAN SGVILQTYHL SSNGDSIVHG RYMPLQDKIL FWDGHNLGLR GDYNGVLLLD TILQAPIGQN DDYIKLEIIL SEAIIFQNCI TELESEGLEC PCDISNELTQ KINQAQLKAK KGIKAQRWNT ICLEVPYSSL KLVSNNMVIL LKRLERHIPV LAIASAINER LTDMMMGSRV PDFGWNFSNF QRVLMHSEAV RRQTFEKWPH MDYKWALPDQ MAQAGFYHQP SSSGEDRAMC FTCSVCLVCW EKTDEPWSEH ERHSPLCPFV KGEYTQNVPL SITYATNPAL PAPGLGFDII SNSDYANVLC TSCSQTGELS VWSIERHLKL MHTFHVPTLL NYIFEESFEW ARVTAICVLP NARARTKVNY VYSAANYGGS GSSNGAGCNS GLNAVSGGKF GSVNAQHITS TSTLRAGVVG SKIVLGVSVR QSSGELALRM VVLNIVEVDR NSESSTSVSN DSGSVSSGGG QLMKSSSPMV NVSAENNATV TQVNLESKDD DNKAMTPYEK FADGFDSNGF VSALMTYNKN NGVSQNTDDA SALYDFDLCT LSQILDHNLE EPLSLMVGSS NTVNVSNIGM GNEINKLVVD VEISHQNNNN NNNNNNEASS LGGNSSNNNN NIMINGGTNS SIDKMTAIEE IDCVVESWTS VKRMNALDGA SSGVNGVNHM DQEVIEIAEI LPTTPKCNQL LVKLLRTKAP EAEGSKIIMA TVAKEEEEED EEQRTDESME TDNNAEGNVA AQLLVFDYDD TEISNDYTLA MTFSRAKFPK QLCILPHFNS SPEHKDAGSI CVVCADGTVE IYSLADFQGT MVIEEEGEHF ESVVYCRNLD RLCCCSRQGG LLFYSLSDGE NDSGDELLEM DDDCSTTLTQ AADVSVTDGG RQLARTDLLG KTLLANESIC MDAGSEAAAI PNSSSAAQGA HVQTSPSASS APSTNANLLA YKTADLTLED LKVFYALTQF DDKLTVYSAE VPSCWNDIGQ VQNQRKQSQN MRHGGDERDF TRTWRLHNDA TTWDEHIIEL NLAQPVSLGH IDLKFTVYQQ CSNPAAIQVT LLKQNNNGFG YRMKGPHSSY KPNVIDDNID LSYIANENPV LSEEYLLAHN AEVLAGPIEL SSCIDLCDQG GTATLTSPKL FKTRTRNFLL HIKTVSDPSK DGQNKTRGCD WLHEISISVR AVKSHSRISN GRMQRIAMLE SNVLLVQLLR IASDPASSSL AKNLSLDILN WICFIRLNRF RSPKSERLKD QINKQTAANI QDLLAQQFEC ISLAEKHIEQ LLRNCVIYSE RSTAHKCVKL LIMLTEGATN LPAEVQDHTT LDYSFKAAIA NTFPELPRAQ CGSVVRWYMM LTCATSTAES HNSISEQAIS LLKEIAAEID KRWDPHCALL CTRFGLYGYP FEPEIFDFDF PNVSRQGPGS SVANVIRSSP TILPVTGLDI KRLSSIDGVD FRTFPYLIRG KSISNQLRGL LEVVQLHFNC VQTSEATRID NIDSVGGNTG ANVIIEDVMM MPKQVVAKEK GEEMLNDLVN DVECLVEEMK VDENEKQEKV DYDAFGLVNG FKDKTLSSLN SVKQTLKEEV KKEKADIMDK LTIAKFLPKL SLLESYMQKK INEHISFDDF GKLDNWDGNT TPPFNLEVEA PIVCSEATSE SNMSQQATSA GGNILDDAAD SEKITESLNA NPCQPIAWHK LITPPPKQMI VIDRMHSGAR RFVVLDFGQH ILLTDLVIPS CDELTSLNID IWCFDEETDC TRLVQVNDIQ TKTLVLSDIQ PAPICRYLKL TIIGRIGMSA TKCKVPLGRF FGHPVVLEHD GYGDQLMKYI KHPTHSLQSQ IKSLNALYED VHCRYSLASS KLMDLLAPMR NSELSNVAHL QAFINKQREE ELSGLENNNK VVSLYDECML LQYQINVIRN VVLRLERALS PNSPTTTLLP GQSIPLTEDI LRAASRDKLR VLSLSLVEVL LHFSIEYGIK NILPVHQRFN AATAKALFNA LVVYGDAQLQ LATCSLLVRM CCFQPWWGDF LADTFCSLFS AQNCKAFPQD RIFFLLTYLG RRSIAMGACR SIVIDAVLKT LVKLLAPISP HYKFQSEQPS TSANAADRNA AMGTTSDLQL ITWLLLFLSV CLDDNERKDK SAARWDFMSC EGDFTKARPS ATPNIKQLRC FKKRIIQQNK YLAQPYADWG KKIYMIQNEH PGIFMELSTK SKGAGPTKST STGGKINMGS SGLCVGGPSS SSGNTSKSAA SSSSPKNQAV PGTDGERDSN FDKGLKSLRM DNIKVVIRGL FALLLEMDFD CNMDQFLLTC KVIARLVAAC RPSVQLCKIV TIAQLQQLVR LSVWNDQQHP WAVHAITCLL QDLLDADKQF RDNDVTPTND TPRTMEAAIQ ETRDLFSDYT STASSCTEAL FETLMPTARE FYQEAVKYNY LPSLIECDDT EFDEMLNDID MIERTKPVTK KESNALSKNT FNFFCKSISI ALDSRLDVGL ELHVETQLRR LTNRTSLDLY SSLPQVLTNE FVSPPPEAAP WPEYLTQLWS GTEYNGDNTY VMFKRVFDSI LAELHLEDTW VHLEQVLQMW LTLNCELSDK PYTSGITHSD VPKIPFGANA VQGLLLALAW HSDIKLRTWC LGFQCLFLAC NSLPIGDDAD CTRINEAIVN DENFEKVLLR FFSGYGMSSS IITNRCAGPT ICKHLHELLL WLHSKSETSG IPCKRRLKDI LLHVVLQLVQ PGGSISNQQG PIDAQNQLVR DLLMMPNDKG DLNIALKITE SVSFLVYNNI SNGERLQCQR GNENSPVGNN FSNLFANVLG SENPNKQNAA ICDNSLIINL LKLSSHMVLT EMPRQPSEVT IPEEEELSNQ SQTDETKAEQ LNTEGHRSKV PCIADWVLRH FPTMKRLFGT LSQCSTNTFT MMSSGCFFSP KSNMILDDPQ TIADAVFSLM ITLNDKASHP RLVVVPICRY LEETTIPRNA TLPRLPHSEP FLWYISKVLE VPAAVQTFTQ LGGIQIICHS LVRLNKTIIN MQPGLISLIM QHLTRNTRFK RNNHVAASSA CKKTTTGTGT TCPTSAQPPR SAAQYDGLIN FAPFSHIVSE NDATQSAEVL ISNPNNSHRR PRSPAWTYMF YPNETHVDLT ITLPTAILLK EVQLVPHTTS LASCPSAVAL ELSRDYGLGS IPVGAPMATT GLTCIRLKLA KAEVATSIVL RLYKPKDCGN VGLVQIAVLG QTIFGNRMHG LRSPSPFIDS LATCSSPVQT AVLAAMDADS MLEDDAFAKT SIGWVRILSR CFHVAALQPD SKLADLIAAY PAAYPGFLEA CCSLLNIMPM IPSLAQQHLE TILLKLSAYN HEISLQLLRT LLWHTTPQVF KLSSDSVCDL IYEVVTGSTE HLLDKLRVLI DWVMQLHDNY SKQARCNNPQ SGFVKVIASI LWKVHTQQQL PELPLLISSS LFETCFEWVS SLEHDEPLKS SFDSLLCALC FIKPELFNQL LVKLGVKLEP PARGQTDDSK VQSGSAWFRR EGSENLSVLL QRPTFLKTLA LACQSPAAVY QMLDSGLPKL LAHAIYEYCM HLMPGSEPVA SASTVPEDEP LANNQAAAAA DDEDSSLTDF DKAEANVVYN TPLLSSSNVP KVLDFFAECC AEGPMRDWLG TMQGSVFWKP LLQLLCNTHA AQFSKTLPKE QSFIRLERAT INFFTRVSAC HPGNQENLTS LLIGAIICKP LRFSHGVRPT ISGFTRQMVL QLLLENEHIT VSVRSQQPLQ RRDTLSAVLG GISSGASTSL PVAAVNNHPA RRSSAHHMLF TVTTSTTCQE IMQNCVSVFS NLVYQQPTDQ RAGETSASSS GVSSATAKSS ESKMEKSSFL NFNNVEAGSM EFLTVGAAVA AKDKRIKDAK NQAAMNKDKE TQTSSTNLAS NIFNVDEFLL QSANAVNGNQ LVIPEYSDIV LAGDATISQV LASLQNAGHS LSTPCISFDL VLQQRSDDTS EAKKTKAACT EPLPSPLQRF SSSGGLSLLA HYLPTVYPEH SGRKTTLVFS EKEKSPPLSD WVKLEPNDEI YEDLEDTLCE PAAKLATVSS VPQHSLAAFG LFLRLPAYSD VLLRDKMRAQ CLLRLVLGVT GDGDGNDIYS LSLAPSLPTL PFEVFRQLLD SVPLSTDDGV LLRRVVIEVG AMHLVLNCLG IFSHQSHNNR IGAPISEPSP SGTSSGSGTI GNGSGNGSVS GTKTNAPEEA TPSATSDDKS HMYWAKGTGF GTGSTTQSWN VEQALLRQKS EEEHVTVLLL VLASYINPGD CIPSEMCGED ILAYHDVRDV TGELPPIFQT LLQQSCLIPA LSSYLRNDSV LDITRHIPLY RAILKLLRAL SLSKMLVSLL QPSASGSGDS TPPIVELLTS MKTCVDTYAK RLKVNKKSNI KGQTHQLTFN IDDGDDEGLA LLIPDIHETS VLVQKTTDAD ALINMLHTNE DGSAQLEPQS KSIEQRYLEL MKKRQFDTFD MIVESDNNSF RFVVSHHFEK MVRLAGDRYH PSRVKRLAQE AVTLSTSLPL SFSSSVFVRC DTDRLDIMKV LITGPADTPY ANGCFEFDVF FPPDYPNQPM LINLETTGRH SVRFNPNLYN DGKVCLSVLN TWHGRPEEKW NAQTSSFLQV LVSIQSLILV PEPYFNEPGF ERSRGSPSGT NSSREYNSNI YQACVRWAML EQIRSPSQCF KDVIHKHFWL KREEICAQIE GWIEELGKPQ YTERASRTIS FNSMVLRRHY RHLREELSKL KPPRGLEDLD APFNPVATLP PMDVSAVAPS LAATNTVQAQ PDDAIVTDIT LLGENADECE ADGDAEGDGE VDDGFKGFPQ EEGLLTGEEE VVEILSDTEN ESSMWQ //