ID Q9VGZ5_DROME Unreviewed; 698 AA. AC Q9VGZ5; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 2. DT 24-JUL-2013, entry version 100. DE SubName: Full=Clockwork orange; GN Name=cwo; ORFNames=CG17100, Dmel_CG17100; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- SIMILARITY: Contains 1 Orange domain. CC -!- SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF54527.2; -; Genomic_DNA. DR RefSeq; NP_524775.1; NM_080036.3. DR UniGene; Dm.11736; -. DR ProteinModelPortal; Q9VGZ5; -. DR SMR; Q9VGZ5; 66-119, 123-167. DR STRING; 7227.FBpp0081723; -. DR EnsemblMetazoa; FBtr0082246; FBpp0081723; FBgn0259938. DR GeneID; 44669; -. DR KEGG; dme:Dmel_CG17100; -. DR UCSC; CG17100-RA; d. melanogaster. DR CTD; 44669; -. DR FlyBase; FBgn0259938; cwo. DR GeneTree; ENSGT00700000104130; -. DR InParanoid; Q9VGZ5; -. DR OMA; QDPLSHR; -. DR PhylomeDB; Q9VGZ5; -. DR GenomeRNAi; 44669; -. DR NextBio; 837532; -. DR Bgee; Q9VGZ5; -. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:FlyBase. DR GO; GO:0032922; P:circadian regulation of gene expression; IMP:FlyBase. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:FlyBase. DR GO; GO:0042752; P:regulation of circadian rhythm; IMP:FlyBase. DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR003650; Orange. DR InterPro; IPR018352; Orange_subgr. DR Pfam; PF07527; Hairy_orange; 1. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SMART; SM00511; ORANGE; 1. DR SUPFAM; SSF47459; HLH_basic; 1. DR PROSITE; PS50888; BHLH; 1. DR PROSITE; PS51054; ORANGE; 1. PE 4: Predicted; KW Complete proteome; Nucleus; Reference proteome; Transcription; KW Transcription regulation. SQ SEQUENCE 698 AA; 75106 MW; 028BDB435ABA8683 CRC64; MEPYWNETNG HAAHPVKYES EAAVSSFPYC TESSLNFSTS ATAYSEDDAE YATGRRNKTS RQDPLSHRII EKRRRDRMNS CLADLSRLIP PQYQRKGRGR IEKTEIIEMA IRHLKHLQSE CQQKESDYRS GYMDCMKEAA KFLYDVHMQD FCHRLLGRLQ EHIDEMFKTD CYKSTRSCHM PDNVSASSGS PHQAYHPPLC HLRDMLATSA SDVEHSQDHN DVKDLSFRNH LNQLQRSQQA AAAAAVAAAA VAVANGSSPA SNAGVDSKVP LTNGGGTGGA PPAADNVPSN STGSGSAAAC AGGNSNSSGS NSSNAASSTI CPPAGGSCPA KVTPLAAHQQ PHQAPVITST APHHHHHHTD SSHHDFESSR EPILHTDTSN MHSPPPRDLL LQQHPHLAHS HHTQDSLMSV RMRNYSESSH EIEHNNNYKY KNHIKERFVH ELHDEETSSE HCPVAAHLQS DHSHLQALSE HSKDGTEPEI APIMAKKRKL AEAAANGEIP LEVHTESSNA GASSANRLDK PSPSFNFSDI KDIKAELHNG NSNSSPLLAK LSAVAAAGGQ LSTPSSTTAP LPPRHTFTVP IFALHGQGNY YVPLNVDYNA LVPFLNGMDL LEKSYTSMPV VHPININVNF MPSSPSASLL AAAAAAAVAV GKQQQQQAVV AAGAGLPLST NSAAAQAAAV AAAAVAKAKL EQAMNQSW //