ID   Q9VGZ3_DROME            Unreviewed;       899 AA.
AC   Q9VGZ3;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   25-OCT-2017, entry version 130.
DE   SubName: Full=Iron regulatory protein 1B {ECO:0000313|EMBL:AAF54529.1};
DE            EC=4.2.1.3 {ECO:0000313|EMBL:AAF54529.1};
GN   Name=Irp-1B {ECO:0000313|EMBL:AAF54529.1,
GN   ECO:0000313|FlyBase:FBgn0024957};
GN   Synonyms=144037_at {ECO:0000313|EMBL:AAF54529.1}, C-Acon
GN   {ECO:0000313|EMBL:AAF54529.1}, cACON {ECO:0000313|EMBL:AAF54529.1},
GN   cAcon {ECO:0000313|EMBL:AAF54529.1}, CG6342
GN   {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|FlyBase:FBgn0024957}, dIRP
GN   {ECO:0000313|EMBL:AAF54529.1}, Dmel\CG6342
GN   {ECO:0000313|EMBL:AAF54529.1}, IRF {ECO:0000313|EMBL:AAF54529.1}, IRP
GN   {ECO:0000313|EMBL:AAF54529.1}, IRP-1 {ECO:0000313|EMBL:AAF54529.1},
GN   IRP-1B {ECO:0000313|EMBL:AAF54529.1}, irp-1B
GN   {ECO:0000313|EMBL:AAF54529.1}, IRP1 {ECO:0000313|EMBL:AAF54529.1},
GN   irp1B {ECO:0000313|EMBL:AAF54529.1};
GN   ORFNames=Dmel_CG6342 {ECO:0000313|EMBL:AAF54529.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AAF54529.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- COFACTOR:
CC       Note=Binds 1 [4Fe-4S] cluster per subunit.
CC       {ECO:0000256|RuleBase:RU361275};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361275}.
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC       {ECO:0000256|RuleBase:RU361275}.
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DR   EMBL; AE014297; AAF54529.1; -; Genomic_DNA.
DR   RefSeq; NP_524303.2; NM_079579.3.
DR   UniGene; Dm.1137; -.
DR   ProteinModelPortal; Q9VGZ3; -.
DR   SMR; Q9VGZ3; -.
DR   IntAct; Q9VGZ3; 1.
DR   STRING; 7227.FBpp0081736; -.
DR   PaxDb; Q9VGZ3; -.
DR   PRIDE; Q9VGZ3; -.
DR   EnsemblMetazoa; FBtr0082259; FBpp0081736; FBgn0024957.
DR   GeneID; 41269; -.
DR   KEGG; dme:Dmel_CG6342; -.
DR   UCSC; CG6342-RA; d. melanogaster.
DR   CTD; 41269; -.
DR   FlyBase; FBgn0024957; Irp-1B.
DR   eggNOG; KOG0452; Eukaryota.
DR   eggNOG; COG1048; LUCA.
DR   GeneTree; ENSGT00890000139397; -.
DR   InParanoid; Q9VGZ3; -.
DR   KO; K01681; -.
DR   OMA; MRIIPPG; -.
DR   OrthoDB; EOG091G01IX; -.
DR   PhylomeDB; Q9VGZ3; -.
DR   Reactome; R-DME-917937; Iron uptake and transport.
DR   GenomeRNAi; 41269; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0024957; -.
DR   ExpressionAtlas; Q9VGZ3; differential.
DR   Genevisible; Q9VGZ3; DM.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003994; F:aconitate hydratase activity; IDA:FlyBase.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.19.10; -; 1.
DR   Gene3D; 3.30.499.10; -; 2.
DR   Gene3D; 3.40.1060.10; -; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   PANTHER; PTHR11670; PTHR11670; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   SUPFAM; SSF53732; SSF53732; 1.
DR   TIGRFAMs; TIGR01341; aconitase_1; 1.
DR   PROSITE; PS00450; ACONITASE_1; 1.
DR   PROSITE; PS01244; ACONITASE_2; 1.
PE   1: Evidence at protein level;
KW   4Fe-4S {ECO:0000256|RuleBase:RU361275};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Cytoplasm {ECO:0000256|RuleBase:RU361275};
KW   Iron {ECO:0000256|RuleBase:RU361275};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU361275};
KW   Lyase {ECO:0000313|EMBL:AAF54529.1};
KW   Metal-binding {ECO:0000256|RuleBase:RU361275};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q9VGZ3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN       79    574       Aconitase. {ECO:0000259|Pfam:PF00330}.
FT   DOMAIN      703    829       Aconitase_C. {ECO:0000259|Pfam:PF00694}.
SQ   SEQUENCE   899 AA;  98578 MW;  8F97C67B40DB680E CRC64;
     MSGANPFAQF EKTFSQAGTT YKYFDLASID SKYDQLPYSI RVLLESAVRN CDNFHILEKD
     VQSILGWSPA LKQGSNDVEV SFKPARVILQ DFTGVPAVVD FAAMRDAVLD LGGDPEKINP
     ICPADLVIDH SVQVDFARAP DALAKNQSLE FERNKERFTF LKWGAKAFNN MLIVPPGSGI
     VHQVNLEYLA RVVFENDATD GSKILYPDSV VGTDSHTTMI NGLGVLGWGV GGIEAEAVML
     GQSISMLLPE VIGYKLEGKL SPLVTSTDLV LTITKHLRQL GVVGKFVEFY GPGVAELSIA
     DRATISNMCP EYGATVGYFP IDENTLGYMK QTNRSEKKID IIRQYLKATQ QLRNYADAAQ
     DPKFTQSITL DLSTVVTSVS GPKRPHDRVS VSDMPEDFKS CLSSPVGFKG FAIAPEAQSA
     FGEFQWDDGK TYKLHHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVEKG LSILPYIKTS
     LSPGSGVVTY YLKESGVIPY LEKLGFDIVG YGCMTCIGNS GPLEENVVNT IEKNGLVCAG
     VLSGNRNFEG RIHPNTRANY LASPLLVIAY AIAGRVDIDF EKEPLGVDAN GKNVFLQDIW
     PTRSEIQEVE NKHVIPAMFQ EVYSKIELGS QDWQTLQVSE GKLFSWSADS TYIKRPPFFE
     GMTRDLPKLQ SIQKARCLLF LGDSVTTDHI SPAGSIARTS PAARFLSERN ITPRDFNSYG
     SRRGNDAIMS RGTFANIRLV NKLVEKTGPR TVHIPSQEEL DIFDAAERYR EEGTPLVLVV
     GKDYGSGSSR DWAAKGPFLL GVKAVIAESY ERIHRSNLVG MGIIPLQFLP GQSAETLNLT
     GREVYNIALP ESGLKPGQKI QVEADGTVFE TILRFDTEVD ITYYKNGGIL NYMIRKMLS
//