ID Q9VFW6_DROME Unreviewed; 599 AA. AC Q9VFW6; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 2. DT 10-OCT-2018, entry version 154. DE SubName: Full=Pyrokinin 2 receptor 2, isoform A {ECO:0000313|EMBL:AAF54929.2}; DE SubName: Full=Pyrokinin 2 receptor 2, isoform B {ECO:0000313|EMBL:AAN13555.1}; GN Name=PK2-R2 {ECO:0000313|EMBL:AAF54929.2, GN ECO:0000313|FlyBase:FBgn0038139}; GN Synonyms=anon-WO0170980.193 {ECO:0000313|EMBL:AAF54929.2}, GN anon-WO0170980.194 {ECO:0000313|EMBL:AAF54929.2}, Dm CG8795 GN {ECO:0000313|EMBL:AAF54929.2}, Dmel\CG8795 GN {ECO:0000313|EMBL:AAF54929.2}; GN ORFNames=CG8795 {ECO:0000313|EMBL:AAF54929.2, GN ECO:0000313|FlyBase:FBgn0038139}, Dmel_CG8795 GN {ECO:0000313|EMBL:AAF54929.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF54929.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF54929.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAF54929.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AAF54929.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AAF54929.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AAF54929.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF54929.2; -; Genomic_DNA. DR EMBL; AE014297; AAN13555.1; -; Genomic_DNA. DR RefSeq; NP_731788.1; NM_169505.2. DR RefSeq; NP_731789.1; NM_169506.2. DR UniGene; Dm.14717; -. DR IntAct; Q9VFW6; 2. DR STRING; 7227.FBpp0082241; -. DR EnsemblMetazoa; FBtr0082773; FBpp0082241; FBgn0038139. DR EnsemblMetazoa; FBtr0082774; FBpp0082242; FBgn0038139. DR GeneID; 41638; -. DR KEGG; dme:Dmel_CG8795; -. DR UCSC; CG8795-RA; d. melanogaster. DR CTD; 41638; -. DR FlyBase; FBgn0038139; PK2-R2. DR eggNOG; KOG3656; Eukaryota. DR eggNOG; ENOG410XRW9; LUCA. DR GeneTree; ENSGT00700000104070; -. DR KO; K05052; -. DR OMA; IFAIWIA; -. DR OrthoDB; EOG091G0IDC; -. DR GenomeRNAi; 41638; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0038139; Expressed in 8 organ(s), highest expression level in embryo. DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase. DR GO; GO:0004930; F:G-protein coupled receptor activity; IDA:FlyBase. DR GO; GO:0008188; F:neuropeptide receptor activity; ISM:FlyBase. DR GO; GO:0001653; F:peptide receptor activity; IDA:FlyBase. DR GO; GO:0036401; F:pyrokinin receptor activity; IPI:FlyBase. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:FlyBase. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AAF54929.2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 63 91 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 103 121 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 141 163 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 184 204 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 224 250 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 280 298 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 327 346 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 83 344 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 599 AA; 65522 MW; 2C04B3236D81677E CRC64; MAVKMLPTNS SGVLATDLQL FHNEKFLLNL TQVLNISADN LTSLLQGLEP EELLPTVTPM TPLSLLATLS VGYALIFIAG VLGNLITCIV ISRNNFMHTA TNFYLFNLAI SDMILLCSGM PQDLYNLWHP DNYPFSDSIC ILESVLSETA ANATVLTITA FTVERYIAIC HPFRQHTMSK LSRAVKFIFA IWIAALLLAL PQAIQFSVVM QGMGTSCTMK NDFFAHVFAV SGFLFFGGPM TAICVLYVLI GVKLKRSRLL QALPRRCYDV NRGISAQTRV IRMLVAVAVA FFICWAPFHA QRLMAVYGST SGIESQWFND VFSILDYTSG VLYFLSTCIN PLLYNIMSHK FREAFKVTLA RHFGLGGKNQ GRGLPHTYSA LRRNQTGSLR LHTTDSVRTT MTSMATTTTG LNGSANGSGN GTTTGQSVRL NRVSLDSVQM QGQNRSRQDL FDNPRRMLQT QISQLSSVGD AHSLLEEDLQ FPGEPLQRQP TMCSIDELTD DLAISRSRLK LTRITRPPGG VTGGVAGGST TGAAGSGGVS GDESSGKVRK AKVKVLKSSS PFKGLRTKFN WRARRKGSHK PHEKGATVNG GDTEERAAF //