ID Q9VF20_DROME Unreviewed; 866 AA. AC Q9VF20; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 02-NOV-2010, entry version 96. DE SubName: Full=CG4225; DE EC=3.6.1.3; DE EC=6.1.1.-; DE SubName: Full=Heavy metal tolerance factor 1; DE SubName: Full=SD08058p; GN Name=Hmt-1; ORFNames=CG4225, Dmel_CG4225; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. RX PubMed=18327897; DOI=10.1021/pr700696a; RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; RT "Phosphoproteome analysis of Drosophila melanogaster embryos."; RL J. Proteome Res. 7:1675-1682(2008). RN [4] RP NUCLEOTIDE SEQUENCE. RX PubMed=19001374; DOI=10.1074/jbc.M806501200; RA Sooksa-Nguan T., Yakubov B., Kozlovskyy V.I., Barkume C.M., Howe K.J., RA Thannhauser T.W., Rutzke M.A., Hart J.J., Kochian L.V., Rea P.A., RA Vatamaniuk O.K.; RT "Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. RT DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar RT phytochelatin sequestration."; RL J. Biol. Chem. 284:354-362(2009). RN [5] RP NUCLEOTIDE SEQUENCE. RA Sooksa-nguan T., Vatamaniuk O.K.; RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF55241.1; -; Genomic_DNA. DR EMBL; AY084209; AAL89947.1; -; mRNA. DR EMBL; EU571211; ACE60575.1; -; mRNA. DR RefSeq; NP_650503.1; -. DR UniGene; Dm.1214; -. DR HSSP; P08716; 1MT0. DR ProteinModelPortal; Q9VF20; -. DR SMR; Q9VF20; 233-813. DR IntAct; Q9VF20; 2. DR MINT; MINT-965404; -. DR STRING; Q9VF20; -. DR PRIDE; Q9VF20; -. DR EnsemblMetazoa; FBtr0083188; FBpp0082642; FBgn0038376. DR GeneID; 41925; -. DR KEGG; dme:Dmel_CG4225; -. DR NMPDR; fig|7227.3.peg.13046; -. DR UCSC; CG4225-RA; d. melanogaster. DR CTD; 41925; -. DR FlyBase; FBgn0038376; Hmt-1. DR eggNOG; inNOG07165; -. DR InParanoid; Q9VF20; -. DR OMA; CMSLYLI; -. DR OrthoDB; EOG9S4PPD; -. DR PhylomeDB; Q9VF20; -. DR NextBio; 826288; -. DR ArrayExpress; Q9VF20; -. DR Bgee; Q9VF20; -. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0005774; C:vacuolar membrane; IDA:FlyBase. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro. DR GO; GO:0042624; F:ATPase activity, uncoupled; IEA:EC. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR GO; GO:0046686; P:response to cadmium ion; IGI:FlyBase. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR017940; ABC_transporter_type1. DR InterPro; IPR001140; ABC_transptr_TM_dom. DR InterPro; IPR011527; ABC_transptrTM_dom_typ1. DR InterPro; IPR003593; ATPase_AAA+_core. DR Pfam; PF00664; ABC_membrane; 1. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF90123; ABC_TM_1; 1. DR PROSITE; PS50929; ABC_TM1F; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. PE 1: Evidence at protein level; KW ATP-binding; Complete proteome; Hydrolase; Ligase; Nucleotide-binding. SQ SEQUENCE 866 AA; 97886 MW; 625A6C8BA7679193 CRC64; MLYCPPNVTL SEVWTQHGIS HCFMDTVGPA VYGGFLLLFG SIQLLMYRKY ATRITDPTQI SKSRLFAMQL FLLLLLPVLA LLRFLMNARI YPDSAVYGYM IFSTCVVCFS YPFSICLILK ERYYQLPSMP TRGHGLVLLL FWTLAFINES LAFINLRHED WWFHLKTNKD QIEMGLFVTR FLCSLLIFVL GLKAPGIMAP YNPHQRLDND TANESQGNVQ TGSAFRNGWR KLRTVFPYLW PKKNIALQIA VIVCIILLLA GRVIKLFLPI YRKKLVDSLT IAPIVFRWDF VLIYVALSFL QGGGTGSMGL FNNLRTFLWI RVQQYTTREI EIELFRHLHQ LSLRWHLQRK TGEVLRVMDR GTDSINNLLN YIVFSIAPTI LDLLVAVAYF VYAFNWWFGL IVFLTMFLYI ASTIAITEWR TKYQRRMNLA DNEQRARSVD SLLNFETVKY YGAEHYEVDC YREAILKYQK EEFLSMLTLN MLNTAQNIIL CLGLLAGSLL CVYLVVHHQT LTVGDFVLFS TYLMELYMPL NWFGTYYRAI QKNFVDMENM FDLLKEEEEI VDAPGCSPLL TAGGGIEFSN VTFGYSPEKI VLRNVSFTVP AGKTVAIVGP SGAGKSTIMR LLFRFYDVQT GAILIDGQNI KLVQQQSLRK AIGVVPQDTV LFNNTIFYNI EYAKLGASDE AVYEAARAAD IHERILGFPE KYETKVGERG LRLSGGEKQR VAIARTLLKA PIIVLLDEAT SALDTHTERN IQAALARVCA NRTTIIVAHR LSTIIHADEI LVLQQGSIAE RGRHEELVLR EDGIYADMWQ QQLKNLDAEQ SGGSDNGDAS AESGSEKRRA GGAGGPSGTG TGGAHFRAGH AHGGAR //