ID Q9VF20_DROME Unreviewed; 866 AA. AC Q9VF20; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 18-JAN-2017, entry version 158. DE SubName: Full=Heavy metal tolerance factor 1 {ECO:0000313|EMBL:AAF55241.1}; DE EC=3.6.1.3 {ECO:0000313|EMBL:AAF55241.1}; DE SubName: Full=SD08058p {ECO:0000313|EMBL:AAL89947.1}; GN Name=Hmt-1 {ECO:0000313|EMBL:AAF55241.1, GN ECO:0000313|FlyBase:FBgn0038376}; GN ORFNames=CG4225 {ECO:0000313|EMBL:AAL89947.1, GN ECO:0000313|FlyBase:FBgn0038376}, Dmel_CG4225 GN {ECO:0000313|EMBL:AAF55241.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAL89947.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF55241.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF55241.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF55241.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:ACE60575.1} RP NUCLEOTIDE SEQUENCE. RA Sooksa-nguan T., Vatamaniuk O.K.; RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:ACE60575.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19001374; DOI=10.1074/jbc.M806501200; RA Sooksa-Nguan T., Yakubov B., Kozlovskyy V.I., Barkume C.M., Howe K.J., RA Thannhauser T.W., Rutzke M.A., Hart J.J., Kochian L.V., Rea P.A., RA Vatamaniuk O.K.; RT "Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. RT DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar RT phytochelatin sequestration."; RL J. Biol. Chem. 284:354-362(2009). RN [14] {ECO:0000313|EMBL:AAF55241.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Contains 1 ABC transporter domain. CC {ECO:0000256|PROSITE-ProRule:PRU00434, CC ECO:0000256|RuleBase:RU363033}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF55241.1; -; Genomic_DNA. DR EMBL; AY084209; AAL89947.1; -; mRNA. DR EMBL; EU571211; ACE60575.1; -; mRNA. DR RefSeq; NP_650503.1; NM_142246.3. DR UniGene; Dm.1214; -. DR ProteinModelPortal; Q9VF20; -. DR SMR; Q9VF20; -. DR IntAct; Q9VF20; 3. DR MINT; MINT-965404; -. DR STRING; 7227.FBpp0082642; -. DR EnsemblMetazoa; FBtr0083188; FBpp0082642; FBgn0038376. DR GeneID; 41925; -. DR KEGG; dme:Dmel_CG4225; -. DR UCSC; CG4225-RA; d. melanogaster. DR CTD; 41925; -. DR FlyBase; FBgn0038376; Hmt-1. DR eggNOG; KOG0057; Eukaryota. DR eggNOG; COG5265; LUCA. DR GeneTree; ENSGT00440000033373; -. DR KO; K05663; -. DR OMA; RYQEAII; -. DR OrthoDB; EOG091G02G4; -. DR PhylomeDB; Q9VF20; -. DR Reactome; R-DME-1369007; Mitochondrial ABC transporters. DR GenomeRNAi; 41925; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0038376; -. DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:FlyBase. DR GO; GO:0005774; C:vacuolar membrane; IDA:FlyBase. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; ISS:FlyBase. DR GO; GO:0015232; F:heme transporter activity; ISS:FlyBase. DR GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central. DR GO; GO:0015886; P:heme transport; ISS:FlyBase. DR GO; GO:0046686; P:response to cadmium ion; IGI:FlyBase. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR032410; MTABC_N. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF00664; ABC_membrane; 1. DR Pfam; PF00005; ABC_tran; 1. DR Pfam; PF16185; MTABC_N; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF90123; SSF90123; 1. DR PROSITE; PS50929; ABC_TM1F; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434, KW ECO:0000256|RuleBase:RU363033}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Hydrolase {ECO:0000313|EMBL:AAF55241.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434, KW ECO:0000256|RuleBase:RU363033}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q9VF20}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 30 47 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 67 85 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 97 119 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 135 154 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 174 192 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 245 271 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 291 311 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 368 390 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 396 417 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 488 506 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 252 542 ABC transmembrane type-1. FT {ECO:0000259|PROSITE:PS50929}. FT DOMAIN 576 810 ABC transporter. {ECO:0000259|PROSITE: FT PS50893}. FT NP_BIND 609 616 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00434}. SQ SEQUENCE 866 AA; 97886 MW; 625A6C8BA7679193 CRC64; MLYCPPNVTL SEVWTQHGIS HCFMDTVGPA VYGGFLLLFG SIQLLMYRKY ATRITDPTQI SKSRLFAMQL FLLLLLPVLA LLRFLMNARI YPDSAVYGYM IFSTCVVCFS YPFSICLILK ERYYQLPSMP TRGHGLVLLL FWTLAFINES LAFINLRHED WWFHLKTNKD QIEMGLFVTR FLCSLLIFVL GLKAPGIMAP YNPHQRLDND TANESQGNVQ TGSAFRNGWR KLRTVFPYLW PKKNIALQIA VIVCIILLLA GRVIKLFLPI YRKKLVDSLT IAPIVFRWDF VLIYVALSFL QGGGTGSMGL FNNLRTFLWI RVQQYTTREI EIELFRHLHQ LSLRWHLQRK TGEVLRVMDR GTDSINNLLN YIVFSIAPTI LDLLVAVAYF VYAFNWWFGL IVFLTMFLYI ASTIAITEWR TKYQRRMNLA DNEQRARSVD SLLNFETVKY YGAEHYEVDC YREAILKYQK EEFLSMLTLN MLNTAQNIIL CLGLLAGSLL CVYLVVHHQT LTVGDFVLFS TYLMELYMPL NWFGTYYRAI QKNFVDMENM FDLLKEEEEI VDAPGCSPLL TAGGGIEFSN VTFGYSPEKI VLRNVSFTVP AGKTVAIVGP SGAGKSTIMR LLFRFYDVQT GAILIDGQNI KLVQQQSLRK AIGVVPQDTV LFNNTIFYNI EYAKLGASDE AVYEAARAAD IHERILGFPE KYETKVGERG LRLSGGEKQR VAIARTLLKA PIIVLLDEAT SALDTHTERN IQAALARVCA NRTTIIVAHR LSTIIHADEI LVLQQGSIAE RGRHEELVLR EDGIYADMWQ QQLKNLDAEQ SGGSDNGDAS AESGSEKRRA GGAGGPSGTG TGGAHFRAGH AHGGAR //