ID RPB4_DROME Reviewed; 139 AA. AC Q9VEA5; Q4V3P8; Q8I0A4; DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 03-APR-2007, sequence version 5. DT 14-OCT-2015, entry version 108. DE RecName: Full=DNA-directed RNA polymerase II 16 kDa polypeptide; DE EC=2.7.7.6; DE AltName: Full=RNA polymerase II accessory factor rpb4; GN Name=Rpb4; ORFNames=CG33520; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAN88031.1} RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION. RX PubMed=12482983; DOI=10.1128/MCB.23.1.306-321.2003; RA Muratoglu S., Georgieva S., Papai G., Scheer E., Enunlu I., RA Komonyi O., Cserpan I., Lebedeva L., Nabirochkina E., Udvardy A., RA Tora L., Boros I.; RT "Two different Drosophila ADA2 homologues are present in distinct GCN5 RT histone acetyltransferase-containing complexes."; RL Mol. Cell. Biol. 23:306-321(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000305} RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000312|EMBL:AAY51562.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP FUNCTION. RX PubMed=12697829; DOI=10.1128/MCB.23.9.3305-3319.2003; RA Kusch T., Guelman S., Abmayr S.M., Workman J.L.; RT "Two Drosophila Ada2 homologues function in different multiprotein RT complexes."; RL Mol. Cell. Biol. 23:3305-3319(2003). CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription CC of DNA into RNA using the four ribonucleoside triphosphates as CC substrates. Associates with POLR2G. {ECO:0000269|PubMed:12482983, CC ECO:0000269|PubMed:12697829}. CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000305}. CC -!- SUBUNIT: RNA polymerase II consists of 12 different subunits. CC {ECO:0000250|UniProtKB:O15514}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12482983}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=D {ECO:0000269|PubMed:10731132}; CC IsoId=Q9VEA5-1; Sequence=Displayed; CC Name=B; CC IsoId=Q7KSD8-1; Sequence=External; CC Note=No experimental confirmation available. {ECO:0000305}; CC Name=A; CC IsoId=Q7KSD8-2; Sequence=External; CC Note=No experimental confirmation available. {ECO:0000305}; CC Name=C {ECO:0000269|PubMed:12482983}; Synonyms=ADA2A-SV2 CC {ECO:0000269|PubMed:12482983}; CC IsoId=Q7KSD8-3; Sequence=External; CC Name=E {ECO:0000269|PubMed:12482983}; Synonyms=ADA2A-SV1 CC {ECO:0000269|PubMed:12482983}; CC IsoId=Q7KSD8-4; Sequence=External; CC -!- MISCELLANEOUS: Three distinct zinc-containing RNA polymerases are CC found in eukaryotic nuclei: polymerase I for the ribosomal RNA CC precursor, polymerase II for the mRNA precursor, and polymerase CC III for 5S and tRNA genes. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the eukaryotic RPB4 RNA polymerase subunit CC family. {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF544019; AAN88031.1; -; mRNA. DR EMBL; AF544020; AAN88032.1; -; mRNA. DR EMBL; AE014297; AAF55522.5; -; Genomic_DNA. DR EMBL; BT022168; AAY51562.1; -; mRNA. DR EMBL; BT023308; AAY55724.1; -; mRNA. DR EMBL; BT023309; AAY55725.1; -; mRNA. DR RefSeq; NP_001014633.2; NM_001014633.3. [Q9VEA5-1] DR UniGene; Dm.13710; -. DR ProteinModelPortal; Q9VEA5; -. DR SMR; Q9VEA5; 11-138. DR IntAct; Q9VEA5; 3. DR MINT; MINT-764159; -. DR STRING; 7227.FBpp0302530; -. DR PRIDE; Q9VEA5; -. DR GeneID; 14462484; -. DR KEGG; dme:Dmel_CG43662; -. DR UCSC; CG33520-RA; d. melanogaster. [Q9VEA5-1] DR CTD; 14462484; -. DR FlyBase; FBgn0263757; Rpb4. DR eggNOG; COG5114; -. DR KO; K03012; -. DR OMA; AKFERAQ; -. DR OrthoDB; EOG7RFTK1; -. DR Reactome; R-DME-110302; Formation of transcription-coupled NER (TC-NER) repair complex. DR Reactome; R-DME-110304; Dual incision reaction in TC-NER. DR Reactome; R-DME-112382; Formation of RNA Pol II elongation complex. DR Reactome; R-DME-113418; Formation of the Early Elongation Complex. DR Reactome; R-DME-674695; RNA Polymerase II Pre-transcription Events. DR Reactome; R-DME-72086; mRNA Capping. DR Reactome; R-DME-72163; mRNA Splicing - Major Pathway. DR Reactome; R-DME-72165; mRNA Splicing - Minor Pathway. DR Reactome; R-DME-72203; Processing of Capped Intron-Containing Pre-mRNA. DR Reactome; R-DME-73776; RNA Polymerase II Promoter Escape. DR Reactome; R-DME-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. DR Reactome; R-DME-73937; Transcription-coupled NER (TC-NER). DR Reactome; R-DME-75953; RNA Polymerase II Transcription Initiation. DR Reactome; R-DME-75955; RNA Polymerase II Transcription Elongation. DR Reactome; R-DME-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance. DR Reactome; R-DME-77075; RNA Pol II CTD phosphorylation and interaction with CE. DR GenomeRNAi; 14462484; -. DR NextBio; 847197; -. DR PRO; PR:Q9VEA5; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; Q9VEA5; -. DR Genevisible; Q9VEA5; DM. DR GO; GO:0005665; C:DNA-directed RNA polymerase II, core complex; IDA:UniProtKB. DR GO; GO:0005700; C:polytene chromosome; IDA:FlyBase. DR GO; GO:0005705; C:polytene chromosome interband; IDA:FlyBase. DR GO; GO:0003899; F:DNA-directed RNA polymerase activity; IDA:UniProtKB. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase. DR GO; GO:0022008; P:neurogenesis; IMP:FlyBase. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB. DR InterPro; IPR010997; HRDC-like. DR InterPro; IPR005574; RNA_pol_II_Rpb4. DR InterPro; IPR006590; RNA_pol_II_Rpb4_core. DR Pfam; PF03874; RNA_pol_Rpb4; 1. DR SMART; SM00657; RPOL4c; 1. DR SUPFAM; SSF47819; SSF47819; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; DNA-directed RNA polymerase; KW Nucleotidyltransferase; Nucleus; Reference proteome; Transcription; KW Transferase. FT CHAIN 1 139 DNA-directed RNA polymerase II 16 kDa FT polypeptide. FT /FTId=PRO_0000283732. FT CONFLICT 124 126 LRQ -> ARE (in Ref. 1; AAN88031/ FT AAN88032). {ECO:0000305}. SQ SEQUENCE 139 AA; 16212 MW; F7541C9A08C23CB1 CRC64; MSFMNPVDMV DEDAADLQFP KEFENAETLL ISEVHMLLDH RKRQNESADE EQEFSEVFMK TYAYTDSFRK FKNKETIMSA RSLLMQKKLH KFELAALGNL CPEAPEEAKA LIPSLEGRFE DEELRQILDD IGTKRSLQY //