ID Q9VCN7_DROME Unreviewed; 915 AA. AC Q9VCN7; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 12-AUG-2020, entry version 173. DE SubName: Full=FI20148p1 {ECO:0000313|EMBL:AFH68357.1}; DE SubName: Full=Oo18 RNA-binding protein, isoform A {ECO:0000313|EMBL:AAF56120.1}; DE SubName: Full=Oo18 RNA-binding protein, isoform G {ECO:0000313|EMBL:AGB96250.1}; GN Name=orb {ECO:0000313|EMBL:AAF56120.1, GN ECO:0000313|FlyBase:FBgn0004882}; GN Synonyms=151666_s_at {ECO:0000313|EMBL:AAF56120.1}, Dmel\CG10868 GN {ECO:0000313|EMBL:AAF56120.1}, fs(3)00107 GN {ECO:0000313|EMBL:AAF56120.1}, Oo18 {ECO:0000313|EMBL:AAF56120.1}, GN oo18 {ECO:0000313|EMBL:AAF56120.1}, ORB {ECO:0000313|EMBL:AAF56120.1}, GN Orb {ECO:0000313|EMBL:AAF56120.1}, orb-RA GN {ECO:0000313|EMBL:AFH68357.1}, Orb1 {ECO:0000313|EMBL:AAF56120.1}; GN ORFNames=CG10868 {ECO:0000313|EMBL:AAF56120.1, GN ECO:0000313|FlyBase:FBgn0004882}, Dmel_CG10868 GN {ECO:0000313|EMBL:AAF56120.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF56120.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF56120.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAF56120.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AFH68357.1} RP NUCLEOTIDE SEQUENCE. RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AAF56120.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAF56120.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAF56120.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [15] {ECO:0000313|EMBL:AAF56120.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF56120.1; -; Genomic_DNA. DR EMBL; BT133433; AFH68357.1; -; mRNA. DR EMBL; AE014297; AGB96250.1; -; Genomic_DNA. DR RefSeq; NP_001262870.1; NM_001275941.1. DR RefSeq; NP_524460.2; NM_079736.3. DR STRING; 7227.FBpp0083776; -. DR EnsemblMetazoa; FBtr0084384; FBpp0083776; FBgn0004882. DR EnsemblMetazoa; FBtr0334498; FBpp0306565; FBgn0004882. DR GeneID; 42752; -. DR UCSC; CG10868-RA; d. melanogaster. DR CTD; 42752; -. DR FlyBase; FBgn0004882; orb. DR eggNOG; KOG0129; Eukaryota. DR GeneTree; ENSGT00940000155524; -. DR HOGENOM; CLU_292909_0_0_1; -. DR OMA; SSFDYFQ; -. DR OrthoDB; 385970at2759; -. DR BioGRID-ORCS; 42752; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 42752; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0004882; Expressed in cleaving embryo and 29 other tissues. DR GO; GO:0005938; C:cell cortex; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central. DR GO; GO:0043005; C:neuron projection; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:1990904; C:ribonucleoprotein complex; IPI:FlyBase. DR GO; GO:0045202; C:synapse; IBA:GO_Central. DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central. DR GO; GO:0003729; F:mRNA binding; ISS:FlyBase. DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central. DR GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central. DR GO; GO:0000900; F:translation repressor activity, mRNA regulatory element binding; IBA:GO_Central. DR GO; GO:0008069; P:dorsal/ventral axis specification, ovarian follicular epithelium; IMP:FlyBase. DR GO; GO:0007281; P:germ cell development; IMP:FlyBase. DR GO; GO:0006378; P:mRNA polyadenylation; IMP:FlyBase. DR GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central. DR GO; GO:0007314; P:oocyte anterior/posterior axis specification; IMP:FlyBase. DR GO; GO:0007310; P:oocyte dorsal/ventral axis specification; IMP:FlyBase. DR GO; GO:0045451; P:pole plasm oskar mRNA localization; IMP:FlyBase. DR GO; GO:0046011; P:regulation of oskar mRNA translation; IMP:FlyBase. DR CDD; cd12723; RRM1_CPEB1; 1. DR Gene3D; 3.30.40.130; -; 1. DR Gene3D; 3.30.70.330; -; 2. DR InterPro; IPR032296; CEBP_ZZ. DR InterPro; IPR038446; CEBP_ZZ_sf. DR InterPro; IPR034819; CPEB. DR InterPro; IPR034977; CPEB1_RRM1. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR PANTHER; PTHR12566; PTHR12566; 1. DR Pfam; PF16366; CEBP_ZZ; 1. DR Pfam; PF16367; RRM_7; 1. DR SMART; SM00360; RRM; 2. DR SUPFAM; SSF54928; SSF54928; 1. DR PROSITE; PS50102; RRM; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00176}; Translation regulation {ECO:0000256|ARBA:ARBA00022845}. FT DOMAIN 576..666 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT REGION 1..27 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 40..59 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 308..355 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 833..870 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 375..401 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 915 AA; 98738 MW; C1DD905BCFA79C46 CRC64; MPLLQQYDTP DCSGSGGNMR ALSGGSTTEL LQKHSISSYL DHHHQQQQQQ QHHLQLQQHQ QQHSLLERCN DDGLISFIND PITLNDLLGL CGASTANEVV GTGQTPSTSA PILGAGGGGR ANGVTAGAAT ATGVGVGAGG TLPGPGVPSI QGGGGGGVVG QQTNASCNTS AANPSASFGG NGSSSDVNNL LLASAAAAAA AAAGDGAQLS ANAAAYAPLT PSSTHSSASP GTKSNFDYFQ FENVAQSNPL KAFQRTNISF DCSAPLSPST PTSIYNRSFH SSPLVSDSSN SSSGIGLSMD SINMFYNQQQ QQQQPEQQGY TSLGNSMGSG LGLSLANAST RSNSPESQNS SNSTTEQNLL DMINLLSVNS NKIPHQQQQQ QQQQQQQQQQ QQQNQQQLQV QQQHQLQQQF VNLNRNYEQQ ISANLGSQQH GFEHNGVGVG ASSSGNENCF SQYNLENITS VDMELAKLQN LQRINTLKLL HAQAQQMPLI NQLLQSYAGN AIGSVGGSNL GNLMSAGGSS LMTEMAGNVG GIITTNDGHL DRVAKFYKSS AALCDATCTW SGHLPPRSHR MLNYSPKVFL GGIPWDISEQ SLIQIFKPFG SIKVEWPGKE QQAAQPKGYV YIIFESDKQV KALLSACVLQ VDDSHCGRNY FFKISSRRIK SKDVEVIPWI IADSNFVRSS SQKLDPTKTV FVGALHGKLT AEGLGNIMDD LFDGVLYAGI DTDKYKYPIG SGRVTFSNFR SYMKAVSAAF IEIRTTKFTK KVQVDPYLED ALCSICGVQH GPYYCRELSC FRYFCRSCWQ WQHSCDIVKN HKPLTRNSKS QSLVGIGPSS SNVSLPFSGQ RSIRDNRMGN GQHQQHQQHQ YQQQKHRQLQ EYSQPHSLNV MGNSGAANAA ATSMVTLQQR QIHKVRIQRQ QHQAI //