ID Q9VBY4_DROME Unreviewed; 223 AA. AC Q9VBY4; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 13-APR-2016, entry version 136. DE SubName: Full=CG11836, isoform A {ECO:0000313|EMBL:AAF56393.1}; DE SubName: Full=CG11836, isoform B {ECO:0000313|EMBL:AAN14039.1}; DE EC=3.4.21.- {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|EMBL:AAN14039.1, ECO:0000313|EMBL:ABW08754.1}; DE SubName: Full=CG11836, isoform C {ECO:0000313|EMBL:ABW08754.1}; DE SubName: Full=CG11836, isoform E {ECO:0000313|EMBL:ADV37381.1}; DE SubName: Full=CG11836, isoform F {ECO:0000313|EMBL:ADV37382.1}; DE SubName: Full=CG11836, isoform G {ECO:0000313|EMBL:ADV37380.1}; DE SubName: Full=LD25830p {ECO:0000313|EMBL:AAL28881.1}; GN ORFNames=CG11836 {ECO:0000313|EMBL:AAF56393.1, GN ECO:0000313|FlyBase:FBgn0039272}, Dmel_CG11836 GN {ECO:0000313|EMBL:AAF56393.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAL28881.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAL28881.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., RA Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., RA Nunoo J., Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., RA Yu C., Lewis S.E., Rubin G.M., Celniker S.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [6] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF56393.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF56393.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF56393.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF56393.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Contains 1 peptidase S1 domain. CC {ECO:0000256|RuleBase:RU363034}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF56393.1; -; Genomic_DNA. DR EMBL; AY061333; AAL28881.1; -; mRNA. DR EMBL; AE014297; AAN14039.1; -; Genomic_DNA. DR EMBL; AE014297; ABW08754.1; -; Genomic_DNA. DR EMBL; AE014297; ADV37380.1; -; Genomic_DNA. DR EMBL; AE014297; ADV37381.1; -; Genomic_DNA. DR EMBL; AE014297; ADV37382.1; -; Genomic_DNA. DR RefSeq; NP_001097910.1; NM_001104440.5. DR RefSeq; NP_001189290.1; NM_001202361.3. DR RefSeq; NP_001189291.1; NM_001202362.3. DR RefSeq; NP_001189292.1; NM_001202363.3. DR RefSeq; NP_651333.1; NM_143076.5. DR RefSeq; NP_733078.1; NM_170199.2. DR UniGene; Dm.3637; -. DR STRING; 7227.FBpp0301202; -. DR MEROPS; S01.B43; -. DR EnsemblMetazoa; FBtr0084767; FBpp0084142; FBgn0039272. DR EnsemblMetazoa; FBtr0084768; FBpp0084143; FBgn0039272. DR EnsemblMetazoa; FBtr0113284; FBpp0112196; FBgn0039272. DR EnsemblMetazoa; FBtr0302404; FBpp0291596; FBgn0039272. DR EnsemblMetazoa; FBtr0302405; FBpp0291597; FBgn0039272. DR EnsemblMetazoa; FBtr0302406; FBpp0291598; FBgn0039272. DR GeneID; 43007; -. DR KEGG; dme:Dmel_CG11836; -. DR UCSC; CG11836-RA; d. melanogaster. DR FlyBase; FBgn0039272; CG11836. DR eggNOG; KOG3627; Eukaryota. DR eggNOG; COG5640; LUCA. DR GeneTree; ENSGT00830000128276; -. DR Reactome; R-DME-977606; Regulation of Complement cascade. DR GenomeRNAi; 43007; -. DR NextBio; 831778; -. DR Proteomes; UP000000803; Chromosome 3R. DR GO; GO:0004252; F:serine-type endopeptidase activity; ISM:FlyBase. DR GO; GO:0006508; P:proteolysis; ISM:FlyBase. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR InterPro; IPR033116; TRYPSIN_SER. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00037407}; KW Hydrolase {ECO:0000256|RuleBase:RU363034, KW ECO:0000313|EMBL:AAF56393.1}; KW Protease {ECO:0000256|RuleBase:RU363034}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Serine protease {ECO:0000256|RuleBase:RU363034}. FT DOMAIN 1 217 Peptidase S1. {ECO:0000259|PROSITE: FT PS50240}. SQ SEQUENCE 223 AA; 24626 MW; 1AE47014802B1DF5 CRC64; MARIVYDGKF HCGGSLLTKD YVLSAAHCVK KLRKSKIRVI FGDHDQEITS ESQAIQRAVT AVIKHKSFDP DTYNNDIALL RLRKPISFSK IIKPICLPRY NYDPAGRIGT VVGWGRTSEG GELPSIVNQV KVPIMSITEC RNQRYKSTRI TSSMLCAGRP SMDSCQGDSG GPLLLSNGVK YFIVGIVSWG VGCGREGYPG VYSRVSKFIP WIKSNLENTC LCS //