ID Q9VB20_DROME Unreviewed; 1323 AA. AC Q9VB20; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 2. DT 22-FEB-2023, entry version 184. DE SubName: Full=Distracted, isoform B {ECO:0000313|EMBL:AAF56723.2}; DE SubName: Full=Distracted, isoform C {ECO:0000313|EMBL:AGB96393.1}; GN Name=dsd {ECO:0000313|EMBL:AAF56723.2, GN ECO:0000313|FlyBase:FBgn0039528}; GN Synonyms=CT17798 {ECO:0000313|EMBL:AAF56723.2}, Dmel\CG5634 GN {ECO:0000313|EMBL:AAF56723.2}; GN ORFNames=CG5634 {ECO:0000313|EMBL:AAF56723.2, GN ECO:0000313|FlyBase:FBgn0039528}, Dmel_CG5634 GN {ECO:0000313|EMBL:AAF56723.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [9] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [10] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [11] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [12] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [13] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF56723.2; -; Genomic_DNA. DR EMBL; AE014297; AGB96393.1; -; Genomic_DNA. DR RefSeq; NP_001263013.1; NM_001276084.1. DR RefSeq; NP_651571.3; NM_143314.4. DR STRING; 7227.FBpp0290604; -. DR EnsemblMetazoa; FBtr0301390; FBpp0290604; FBgn0039528. DR EnsemblMetazoa; FBtr0335247; FBpp0307234; FBgn0039528. DR GeneID; 43315; -. DR KEGG; dme:Dmel_CG5634; -. DR UCSC; CG5634-RA; d. melanogaster. DR AGR; FB:FBgn0039528; -. DR CTD; 43315; -. DR FlyBase; FBgn0039528; dsd. DR VEuPathDB; VectorBase:FBgn0039528; -. DR eggNOG; KOG1388; Eukaryota. DR GeneTree; ENSGT00940000167068; -. DR HOGENOM; CLU_003930_0_0_1; -. DR OMA; EACNIAA; -. DR OrthoDB; 5471913at2759; -. DR BioGRID-ORCS; 43315; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 43315; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0039528; Expressed in spermathecum and 27 other tissues. DR GO; GO:0005886; C:plasma membrane; ISM:FlyBase. DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:FlyBase. DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central. DR GO; GO:0016043; P:cellular component organization; IEA:UniProt. DR GO; GO:0008039; P:synaptic target recognition; IMP:FlyBase. DR GO; GO:0009888; P:tissue development; IBA:GO_Central. DR CDD; cd00041; CUB; 1. DR CDD; cd00055; EGF_Lam; 2. DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2. DR Gene3D; 2.10.25.10; Laminin; 2. DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1. DR InterPro; IPR000859; CUB_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR015915; Kelch-typ_b-propeller. DR InterPro; IPR002049; LE_dom. DR InterPro; IPR016201; PSI. DR InterPro; IPR035914; Sperma_CUB_dom_sf. DR PANTHER; PTHR46376:SF2; DISTRACTED, ISOFORM B; 1. DR PANTHER; PTHR46376; LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1; 1. DR Pfam; PF00431; CUB; 1. DR Pfam; PF13854; Kelch_5; 2. DR SMART; SM00042; CUB; 1. DR SMART; SM00181; EGF; 4. DR SMART; SM00180; EGF_Lam; 2. DR SMART; SM00423; PSI; 5. DR SUPFAM; SSF57196; EGF/Laminin; 1. DR SUPFAM; SSF117281; Kelch motif; 2. DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1. DR PROSITE; PS01180; CUB; 1. DR PROSITE; PS00022; EGF_1; 2. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 2. DR PROSITE; PS50027; EGF_LAM_2; 1. PE 4: Predicted; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..43 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 44..1323 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015100058" FT TRANSMEM 1167..1188 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 49..84 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 86..215 FT /note="CUB" FT /evidence="ECO:0000259|PROSITE:PS01180" FT DOMAIN 249..285 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 949..995 FT /note="Laminin EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50027" FT REGION 1295..1323 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1301..1323 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 74..83 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 275..284 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 967..976 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460" FT DISULFID 979..993 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460" SQ SEQUENCE 1323 AA; 146844 MW; 9913A738738E5224 CRC64; MCLAAEPPQK QPNRSSTSPT FNAKYRRKCL LLLTLLLFHG CFSGLHRAAA FNCTAHGGRC QNDGQCQEDG QCLCADGWQG PECQFCGGKV RMYHPMGTIH DGWGNYSVSV KCSWLIDARH PHWNRRHNTN PSRTANIRIH LREFATECGW DHLYIYDGDS VDSPLLAVFS GLMYRGNFSI RRVPQVIATS GTALVHFFSD DAYNMSGFNL TYKMNSCPSD SDEVECSGHG KCRDGDCICD PMYRGEACNI AACPNNCFES KNQGHCRLDQ ERCSCYEGFA GDDCSQISAH GAWSTVHPKH SPAPAGSASH GATIWRDTLH IVGGESYGRG KLMSTYDFNG NVWETVHPED GSEVPDKRYG ASTVMYGDKI FMYGGVVKGH GISNELWAFD VSARTWANIS VRADPSCNAT GGTTAMCGPL HVVGHTATLV PGYGDKNNYQ YMVVIFGHSP NYGYLNTVQE FNFASREWRI VPTTGYVVKG GYGHSAAYDF LTEKVYVYGG IVSESESSQV LSSRLYAYEP ATRVWSLLSA APSARLLHTA NFVNQGLMMV FGGNTHNDTS QSYGAKCYSQ DLLVYDVYCD SWHYHPMPGH LQADLARFGH SSVVFEESLY IYGGFNGQLL NDMLRYQPGY CSYYTKQEKC TAARPGVKCI WDVQKMRCIA ITQVQRSAIY GREQYDYVAC PSKSRLTLTS ELLHDVHRCQ ELASCQSCVS TAFGCTYCGN GVCSKERCRE TTSMASVFFE SSTQMAVSTA SPPLNAKHLD SCPISEEYLV SSVCDQLHNC RACSANLACR WDSEHNRCKS YTSYGGLALN RTQDEVACSP SCASLTNCQN CTEDECIWCQ NEQRCVDRNA YTASFPYGQC REWTTFTAKC RSAPIQSTAL AVGSTTALSS AQCGYYNSCQ MCLDDPACGW CDNGSNTGLG RCVVGGALAP YDDTECALKH WFFTSCPRCN CNGHSYCNDQ QHCEQPCNNL TTGAHCEKCR TGYWGNPING GKCQRCDCNG QGVYCHPDTG KCFCTTKGIV GDHCEKCDSQ NHYHGDPLKG SCYYELTIDY QFTFNLSKKE DRHFTQINFR NSPGKPEIDA DFTITCSVPA KMDISVKRAG SPDMLILVGV NCSTFRHRFP KTDYQFGHSP DDNSSLTTFY VFVHDFQPPI WIQIAFSQYP KLNLQQFFIT FSSCFLLLLL MAAVLWKIKQ KYDMFRRRQR LFVEMEQMAS RPFSQVLVDI ENRESIDLSL TLEGIGHLSK KRKKECPSPI ALEPCSGNRA AVLSLLVRLP TGGLSQAPSG QSAGLAVASA LVTLGNPRRP SIDQHPKEPK SKRKQSQHPD SCT //