ID Q9VB20_DROME Unreviewed; 1323 AA. AC Q9VB20; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 2. DT 05-JUL-2017, entry version 143. DE SubName: Full=Distracted, isoform B {ECO:0000313|EMBL:AAF56723.2}; DE SubName: Full=Distracted, isoform C {ECO:0000313|EMBL:AGB96393.1}; GN Name=dsd {ECO:0000313|EMBL:AAF56723.2, GN ECO:0000313|FlyBase:FBgn0039528}; GN ORFNames=CG5634 {ECO:0000313|FlyBase:FBgn0039528}, Dmel_CG5634 GN {ECO:0000313|EMBL:AAF56723.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAF56723.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AAF56723.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; AAF56723.2; -; Genomic_DNA. DR EMBL; AE014297; AGB96393.1; -; Genomic_DNA. DR RefSeq; NP_001263013.1; NM_001276084.1. DR RefSeq; NP_651571.3; NM_143314.4. DR UniGene; Dm.7161; -. DR MINT; MINT-977402; -. DR STRING; 7227.FBpp0290604; -. DR EnsemblMetazoa; FBtr0301390; FBpp0290604; FBgn0039528. DR EnsemblMetazoa; FBtr0335247; FBpp0307234; FBgn0039528. DR GeneID; 43315; -. DR KEGG; dme:Dmel_CG5634; -. DR UCSC; CG5634-RA; d. melanogaster. DR CTD; 43315; -. DR FlyBase; FBgn0039528; dsd. DR eggNOG; KOG1388; Eukaryota. DR eggNOG; ENOG410XRW4; LUCA. DR GeneTree; ENSGT00390000001118; -. DR OMA; CMWCSNM; -. DR OrthoDB; EOG091G03A0; -. DR GenomeRNAi; 43315; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0039528; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008039; P:synaptic target recognition; IMP:FlyBase. DR CDD; cd00041; CUB; 1. DR Gene3D; 2.120.10.80; -; 1. DR Gene3D; 2.130.10.80; -; 1. DR Gene3D; 2.60.120.290; -; 1. DR InterPro; IPR000859; CUB_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR015916; Gal_Oxidase_b-propeller. DR InterPro; IPR015915; Kelch-typ_b-propeller. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR016201; PSI. DR Pfam; PF00431; CUB; 1. DR SMART; SM00042; CUB; 1. DR SMART; SM00181; EGF; 4. DR SMART; SM00180; EGF_Lam; 2. DR SMART; SM00423; PSI; 5. DR SUPFAM; SSF49854; SSF49854; 1. DR PROSITE; PS01180; CUB; 1. DR PROSITE; PS00022; EGF_1; 2. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 2. DR PROSITE; PS50027; EGF_LAM_2; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00580732}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00660484}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00580772}; Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|SAAS:SAAS00580781}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 43 {ECO:0000256|SAM:SignalP}. FT CHAIN 44 1323 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5010685663. FT TRANSMEM 1167 1188 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 49 84 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 86 215 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 249 285 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 949 995 Laminin EGF-like. {ECO:0000259|PROSITE: FT PS50027}. FT DOMAIN 996 1044 Laminin EGF-like. {ECO:0000259|PROSITE: FT PS50027}. FT DISULFID 74 83 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 275 284 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 967 976 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 979 993 {ECO:0000256|PROSITE-ProRule:PRU00460}. SQ SEQUENCE 1323 AA; 146844 MW; 9913A738738E5224 CRC64; MCLAAEPPQK QPNRSSTSPT FNAKYRRKCL LLLTLLLFHG CFSGLHRAAA FNCTAHGGRC QNDGQCQEDG QCLCADGWQG PECQFCGGKV RMYHPMGTIH DGWGNYSVSV KCSWLIDARH PHWNRRHNTN PSRTANIRIH LREFATECGW DHLYIYDGDS VDSPLLAVFS GLMYRGNFSI RRVPQVIATS GTALVHFFSD DAYNMSGFNL TYKMNSCPSD SDEVECSGHG KCRDGDCICD PMYRGEACNI AACPNNCFES KNQGHCRLDQ ERCSCYEGFA GDDCSQISAH GAWSTVHPKH SPAPAGSASH GATIWRDTLH IVGGESYGRG KLMSTYDFNG NVWETVHPED GSEVPDKRYG ASTVMYGDKI FMYGGVVKGH GISNELWAFD VSARTWANIS VRADPSCNAT GGTTAMCGPL HVVGHTATLV PGYGDKNNYQ YMVVIFGHSP NYGYLNTVQE FNFASREWRI VPTTGYVVKG GYGHSAAYDF LTEKVYVYGG IVSESESSQV LSSRLYAYEP ATRVWSLLSA APSARLLHTA NFVNQGLMMV FGGNTHNDTS QSYGAKCYSQ DLLVYDVYCD SWHYHPMPGH LQADLARFGH SSVVFEESLY IYGGFNGQLL NDMLRYQPGY CSYYTKQEKC TAARPGVKCI WDVQKMRCIA ITQVQRSAIY GREQYDYVAC PSKSRLTLTS ELLHDVHRCQ ELASCQSCVS TAFGCTYCGN GVCSKERCRE TTSMASVFFE SSTQMAVSTA SPPLNAKHLD SCPISEEYLV SSVCDQLHNC RACSANLACR WDSEHNRCKS YTSYGGLALN RTQDEVACSP SCASLTNCQN CTEDECIWCQ NEQRCVDRNA YTASFPYGQC REWTTFTAKC RSAPIQSTAL AVGSTTALSS AQCGYYNSCQ MCLDDPACGW CDNGSNTGLG RCVVGGALAP YDDTECALKH WFFTSCPRCN CNGHSYCNDQ QHCEQPCNNL TTGAHCEKCR TGYWGNPING GKCQRCDCNG QGVYCHPDTG KCFCTTKGIV GDHCEKCDSQ NHYHGDPLKG SCYYELTIDY QFTFNLSKKE DRHFTQINFR NSPGKPEIDA DFTITCSVPA KMDISVKRAG SPDMLILVGV NCSTFRHRFP KTDYQFGHSP DDNSSLTTFY VFVHDFQPPI WIQIAFSQYP KLNLQQFFIT FSSCFLLLLL MAAVLWKIKQ KYDMFRRRQR LFVEMEQMAS RPFSQVLVDI ENRESIDLSL TLEGIGHLSK KRKKECPSPI ALEPCSGNRA AVLSLLVRLP TGGLSQAPSG QSAGLAVASA LVTLGNPRRP SIDQHPKEPK SKRKQSQHPD SCT //