ID WECH_DROME Reviewed; 832 AA. AC Q9V4M2; A4IJ45; B7YZS8; Q0E9G5; Q95SY8; DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 2. DT 03-OCT-2012, entry version 92. DE RecName: Full=Protein wech; DE AltName: Full=Protein dappled; GN Name=wech; Synonyms=dpld; ORFNames=CG42396; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RX MEDLINE=22426066; PubMed=12537569; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kapadia B., Kronmiller B., RA Li P.W., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., RA Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., RA Lewis S.E., Rubin G.M., Celniker S.E.; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [5] RP FUNCTION, AND TISSUE SPECIFICITY. RX MEDLINE=96363925; PubMed=8725239; RA Rodriguez A., Zhou Z., Tang M.L., Meller S., Chen J., Bellen H., RA Kimbrell D.A.; RT "Identification of immune system and response genes, and novel RT mutations causing melanotic tumor formation in Drosophila RT melanogaster."; RL Genetics 143:929-940(1996). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-470; SER-475 RP AND SER-506, AND MASS SPECTROMETRY. RC TISSUE=Embryo; RX PubMed=18327897; DOI=10.1021/pr700696a; RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; RT "Phosphoproteome analysis of Drosophila melanogaster embryos."; RL J. Proteome Res. 7:1675-1682(2008). RN [7] RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION RP PHENOTYPE. RX PubMed=18327251; DOI=10.1038/ncb1704; RA Loeer B., Bauer R., Bornheim R., Grell J., Kremmer E., Kolanus W., RA Hoch M.; RT "The NHL-domain protein Wech is crucial for the integrin-cytoskeleton RT link."; RL Nat. Cell Biol. 10:422-428(2008). CC -!- FUNCTION: Vital for larval development. Plays a role in tumor CC formation. A crucial component for the physical link between CC integrins and the cytoskeleton in the epidermal muscle attachment CC sites. CC -!- SUBUNIT: Interacts with the head domain of rhea and the kinase CC domain of Ilk. CC -!- TISSUE SPECIFICITY: Expressed ubiquitously in all epithelial cells CC during early stages of embryogenesis. Specifically expressed at CC epidermal muscle attachment site. CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically CC throughout development. CC -!- DISRUPTION PHENOTYPE: Muscle detachment in late-stage-16/early- CC stage-17 embryos. CC -!- MISCELLANEOUS: 'Wech' means 'detached' or 'gone' in German. CC -!- SIMILARITY: Contains 2 B box-type zinc fingers. CC -!- SIMILARITY: Contains 5 NHL repeats. CC -!- CAUTION: Was originally termed dappled (PubMed:8725239). CC -!- SEQUENCE CAUTION: CC Sequence=AAL25460.1; Type=Frameshift; Positions=591; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AAF59246.2; -; Genomic_DNA. DR EMBL; AE013599; AAM68901.1; -; Genomic_DNA. DR EMBL; AE013599; ACL83068.1; -; Genomic_DNA. DR EMBL; AE013599; ACL83069.1; -; Genomic_DNA. DR EMBL; AY060421; AAL25460.1; ALT_FRAME; mRNA. DR EMBL; BT010087; AAQ22556.1; -; mRNA. DR EMBL; BT030403; ABO52822.1; -; mRNA. DR RefSeq; NP_001137614.1; NM_001144142.1. DR RefSeq; NP_001137615.1; NM_001144143.1. DR RefSeq; NP_524772.2; NM_080033.3. DR RefSeq; NP_724567.1; NM_165533.2. DR RefSeq; NP_724568.1; NM_165534.2. DR UniGene; Dm.1824; -. DR ProteinModelPortal; Q9V4M2; -. DR SMR; Q9V4M2; 116-162, 184-226, 533-814. DR DIP; DIP-21516N; -. DR MINT; MINT-1569933; -. DR STRING; Q9V4M2; -. DR EnsemblMetazoa; FBtr0300080; FBpp0289357; FBgn0259745. DR EnsemblMetazoa; FBtr0300081; FBpp0289358; FBgn0259745. DR EnsemblMetazoa; FBtr0300082; FBpp0289359; FBgn0259745. DR EnsemblMetazoa; FBtr0300083; FBpp0289360; FBgn0259745. DR EnsemblMetazoa; FBtr0300084; FBpp0289361; FBgn0259745. DR GeneID; 44653; -. DR KEGG; dme:Dmel_CG42396; -. DR CTD; 44653; -. DR FlyBase; FBgn0259745; wech. DR eggNOG; COG3391; -. DR GeneTree; ENSGT00550000074377; -. DR KO; K12035; -. DR OMA; ATEGHED; -. DR OrthoDB; EOG4ZPCB5; -. DR PhylomeDB; Q9V4M2; -. DR GenomeRNAi; 44653; -. DR NextBio; 837513; -. DR ArrayExpress; Q9V4M2; -. DR Bgee; Q9V4M2; -. DR GermOnline; CG1624; Drosophila melanogaster. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0005927; C:muscle tendon junction; IDA:FlyBase. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0002168; P:instar larval development; IMP:UniProtKB. DR GO; GO:0016203; P:muscle attachment; IMP:UniProtKB. DR GO; GO:0033632; P:regulation of cell-cell adhesion mediated by integrin; IPI:FlyBase. DR Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR001258; NHL_repeat. DR InterPro; IPR013017; NHL_repeat_subgr. DR InterPro; IPR000315; Znf_B-box. DR Pfam; PF01436; NHL; 5. DR Pfam; PF00643; zf-B_box; 2. DR SMART; SM00336; BBOX; 2. DR PROSITE; PS51125; NHL; 5. DR PROSITE; PS50119; ZF_BBOX; 2. PE 1: Evidence at protein level; KW Complete proteome; Developmental protein; Differentiation; KW Metal-binding; Myogenesis; Phosphoprotein; Reference proteome; Repeat; KW Zinc; Zinc-finger. FT CHAIN 1 832 Protein wech. FT /FTId=PRO_0000220369. FT REPEAT 537 580 NHL 1. FT REPEAT 584 627 NHL 2. FT REPEAT 631 674 NHL 3. FT REPEAT 680 722 NHL 4. FT REPEAT 727 770 NHL 5. FT ZN_FING 118 163 B box-type 1. FT ZN_FING 184 224 B box-type 2. FT MOD_RES 107 107 Phosphoserine. FT MOD_RES 470 470 Phosphoserine. FT MOD_RES 475 475 Phosphoserine. FT MOD_RES 506 506 Phosphoserine. SQ SEQUENCE 832 AA; 90573 MW; A5672AFC3FDE1FE1 CRC64; MMELLSNNSV PQQMASSNAP SANNVAHSST ANGSGGGSVS SNASNSSERL LAGILESFPA WDLNVGLLPN VGQSSPPRAD FFINNFLGGL DTHGDFSIGP IGSGARSNPK MSPESSNNSS ISCGWCEVSA SIRCLECNEF MCNDCLREHR NSPLSSNHSI VSLPTPIGAS PTGGSSVNAQ TPPSGNFICD IHNEMLRYVC DYCRKLVCQC CTLHEHKEHS YASIQSFMVG SKEKLEGAIE SSQVGTRCIK SSIDKALAFI RLIERNCSEL SDNIRKAFRQ FIIAIEDRER FLLDFVEKLR QRRLAILHDQ MAGLKSALAG LSETSDMLSK VADNACNMDQ IEIAMKLTNG QRQMEQFAGI YKDLQPKQEV FAFAPPDYSL LQDIRNQGGV ILVDDKNLPI VSSSNGIVPS VSSVNAVAAA SVGVVGGVAG VVGGVGVSNG LDLAFGMNMP NNPLSVASSS VRRPLLRDNS FRIPSPIMQP RGGSACGMSS GMSSAALDWE LNGLRSSPGL HFSAPRTTQA IPGCMDLVKV RNSNALSLSF ATEGHEDGQV SRPWGLCVDK MGHVLVSDRR NNRVQVFNPD GSLKFKFGRK GVGNGEFDLP AGICVDVDNR IIVVDKDNHR VQIFTASGVF LLKFGSYGKE YGQFQYPWDV AVNSRRQIVV TDSRNHRIQQ FDSEGRFIRQ IVFDNHGQTK GIASPRGVCY TPTGNIIVSD FDNHCLYLID PDINDILSVK GHEGSGFHEF NRPSGLCCDD EGRIIVADSK NQRILVFNQN LDFMWDIEVR PSINPLMPPT LDEKDRTCDV AIMPDGRIVF LIELSPDSKE GSNPYKRFVH VF //