ID   WECH_DROME              Reviewed;         832 AA.
AC   Q9V4M2; A4IJ45; B7YZS8; Q0E9G5; Q95SY8;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   05-SEP-2012, entry version 91.
DE   RecName: Full=Protein wech;
DE   AltName: Full=Protein dappled;
GN   Name=wech; Synonyms=dpld; ORFNames=CG42396;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   MEDLINE=22426066; PubMed=12537569;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W.,
RA   Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA   George R.A., Gonzalez M., Guarin H., Kapadia B., Kronmiller B.,
RA   Li P.W., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M.,
RA   Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C.,
RA   Lewis S.E., Rubin G.M., Celniker S.E.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   MEDLINE=96363925; PubMed=8725239;
RA   Rodriguez A., Zhou Z., Tang M.L., Meller S., Chen J., Bellen H.,
RA   Kimbrell D.A.;
RT   "Identification of immune system and response genes, and novel
RT   mutations causing melanotic tumor formation in Drosophila
RT   melanogaster.";
RL   Genetics 143:929-940(1996).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-470; SER-475
RP   AND SER-506, AND MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=18327251; DOI=10.1038/ncb1704;
RA   Loeer B., Bauer R., Bornheim R., Grell J., Kremmer E., Kolanus W.,
RA   Hoch M.;
RT   "The NHL-domain protein Wech is crucial for the integrin-cytoskeleton
RT   link.";
RL   Nat. Cell Biol. 10:422-428(2008).
CC   -!- FUNCTION: Vital for larval development. Plays a role in tumor
CC       formation. A crucial component for the physical link between
CC       integrins and the cytoskeleton in the epidermal muscle attachment
CC       sites.
CC   -!- SUBUNIT: Interacts with the head domain of rhea and the kinase
CC       domain of Ilk.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously in all epithelial cells
CC       during early stages of embryogenesis. Specifically expressed at
CC       epidermal muscle attachment site.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically
CC       throughout development.
CC   -!- DISRUPTION PHENOTYPE: Muscle detachment in late-stage-16/early-
CC       stage-17 embryos.
CC   -!- MISCELLANEOUS: 'Wech' means 'detached' or 'gone' in German.
CC   -!- SIMILARITY: Contains 2 B box-type zinc fingers.
CC   -!- SIMILARITY: Contains 5 NHL repeats.
CC   -!- CAUTION: Was originally termed dappled (PubMed:8725239).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL25460.1; Type=Frameshift; Positions=591;
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DR   EMBL; AE013599; AAF59246.2; -; Genomic_DNA.
DR   EMBL; AE013599; AAM68901.1; -; Genomic_DNA.
DR   EMBL; AE013599; ACL83068.1; -; Genomic_DNA.
DR   EMBL; AE013599; ACL83069.1; -; Genomic_DNA.
DR   EMBL; AY060421; AAL25460.1; ALT_FRAME; mRNA.
DR   EMBL; BT010087; AAQ22556.1; -; mRNA.
DR   EMBL; BT030403; ABO52822.1; -; mRNA.
DR   RefSeq; NP_001137614.1; NM_001144142.1.
DR   RefSeq; NP_001137615.1; NM_001144143.1.
DR   RefSeq; NP_524772.2; NM_080033.3.
DR   RefSeq; NP_724567.1; NM_165533.2.
DR   RefSeq; NP_724568.1; NM_165534.2.
DR   UniGene; Dm.1824; -.
DR   ProteinModelPortal; Q9V4M2; -.
DR   SMR; Q9V4M2; 116-162, 184-226, 533-814.
DR   DIP; DIP-21516N; -.
DR   MINT; MINT-1569933; -.
DR   STRING; Q9V4M2; -.
DR   EnsemblMetazoa; FBtr0300080; FBpp0289357; FBgn0259745.
DR   EnsemblMetazoa; FBtr0300081; FBpp0289358; FBgn0259745.
DR   EnsemblMetazoa; FBtr0300082; FBpp0289359; FBgn0259745.
DR   EnsemblMetazoa; FBtr0300083; FBpp0289360; FBgn0259745.
DR   EnsemblMetazoa; FBtr0300084; FBpp0289361; FBgn0259745.
DR   GeneID; 44653; -.
DR   KEGG; dme:Dmel_CG42396; -.
DR   CTD; 44653; -.
DR   FlyBase; FBgn0259745; wech.
DR   eggNOG; COG3391; -.
DR   GeneTree; ENSGT00550000074377; -.
DR   KO; K12035; -.
DR   OMA; ATEGHED; -.
DR   OrthoDB; EOG4ZPCB5; -.
DR   PhylomeDB; Q9V4M2; -.
DR   GenomeRNAi; 44653; -.
DR   NextBio; 837513; -.
DR   ArrayExpress; Q9V4M2; -.
DR   Bgee; Q9V4M2; -.
DR   GermOnline; CG1624; Drosophila melanogaster.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005927; C:muscle tendon junction; IDA:FlyBase.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0002168; P:instar larval development; IMP:UniProtKB.
DR   GO; GO:0016203; P:muscle attachment; IMP:UniProtKB.
DR   GO; GO:0033632; P:regulation of cell-cell adhesion mediated by integrin; IPI:FlyBase.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR000315; Znf_B-box.
DR   Pfam; PF01436; NHL; 5.
DR   Pfam; PF00643; zf-B_box; 2.
DR   SMART; SM00336; BBOX; 2.
DR   PROSITE; PS51125; NHL; 5.
DR   PROSITE; PS50119; ZF_BBOX; 2.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   Metal-binding; Myogenesis; Phosphoprotein; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    832       Protein wech.
FT                                /FTId=PRO_0000220369.
FT   REPEAT      537    580       NHL 1.
FT   REPEAT      584    627       NHL 2.
FT   REPEAT      631    674       NHL 3.
FT   REPEAT      680    722       NHL 4.
FT   REPEAT      727    770       NHL 5.
FT   ZN_FING     118    163       B box-type 1.
FT   ZN_FING     184    224       B box-type 2.
FT   MOD_RES     107    107       Phosphoserine.
FT   MOD_RES     470    470       Phosphoserine.
FT   MOD_RES     475    475       Phosphoserine.
FT   MOD_RES     506    506       Phosphoserine.
SQ   SEQUENCE   832 AA;  90573 MW;  A5672AFC3FDE1FE1 CRC64;
     MMELLSNNSV PQQMASSNAP SANNVAHSST ANGSGGGSVS SNASNSSERL LAGILESFPA
     WDLNVGLLPN VGQSSPPRAD FFINNFLGGL DTHGDFSIGP IGSGARSNPK MSPESSNNSS
     ISCGWCEVSA SIRCLECNEF MCNDCLREHR NSPLSSNHSI VSLPTPIGAS PTGGSSVNAQ
     TPPSGNFICD IHNEMLRYVC DYCRKLVCQC CTLHEHKEHS YASIQSFMVG SKEKLEGAIE
     SSQVGTRCIK SSIDKALAFI RLIERNCSEL SDNIRKAFRQ FIIAIEDRER FLLDFVEKLR
     QRRLAILHDQ MAGLKSALAG LSETSDMLSK VADNACNMDQ IEIAMKLTNG QRQMEQFAGI
     YKDLQPKQEV FAFAPPDYSL LQDIRNQGGV ILVDDKNLPI VSSSNGIVPS VSSVNAVAAA
     SVGVVGGVAG VVGGVGVSNG LDLAFGMNMP NNPLSVASSS VRRPLLRDNS FRIPSPIMQP
     RGGSACGMSS GMSSAALDWE LNGLRSSPGL HFSAPRTTQA IPGCMDLVKV RNSNALSLSF
     ATEGHEDGQV SRPWGLCVDK MGHVLVSDRR NNRVQVFNPD GSLKFKFGRK GVGNGEFDLP
     AGICVDVDNR IIVVDKDNHR VQIFTASGVF LLKFGSYGKE YGQFQYPWDV AVNSRRQIVV
     TDSRNHRIQQ FDSEGRFIRQ IVFDNHGQTK GIASPRGVCY TPTGNIIVSD FDNHCLYLID
     PDINDILSVK GHEGSGFHEF NRPSGLCCDD EGRIIVADSK NQRILVFNQN LDFMWDIEVR
     PSINPLMPPT LDEKDRTCDV AIMPDGRIVF LIELSPDSKE GSNPYKRFVH VF
//