ID Q9V3Z2_DROME Unreviewed; 391 AA. AC Q9V3Z2; Q9I7L2; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 09-DEC-2015, entry version 130. DE SubName: Full=Serine protease 7, isoform A {ECO:0000313|EMBL:AAF54143.1}; DE EC=3.4.16.- {ECO:0000313|EMBL:AAF54143.1}; DE EC=3.4.21.- {ECO:0000313|EMBL:AAF54143.1}; DE SubName: Full=Serine protease 7, isoform E {ECO:0000313|EMBL:AAG22126.1}; DE EC=3.4.16.- {ECO:0000313|EMBL:AAG22126.1}; DE EC=3.4.21.- {ECO:0000313|EMBL:AAG22126.1}; DE SubName: Full=Serine protease 7, isoform F {ECO:0000313|EMBL:AAG22127.2}; DE EC=3.4.16.- {ECO:0000313|EMBL:AAG22127.2}; DE EC=3.4.21.- {ECO:0000313|EMBL:AAG22127.2}; DE SubName: Full=Serine proteinase {ECO:0000313|EMBL:AAF43410.1}; GN Name=Sp7 {ECO:0000313|EMBL:AAF54143.1, GN ECO:0000313|FlyBase:FBgn0037515}; GN ORFNames=CG3066 {ECO:0000313|FlyBase:FBgn0037515}, Dmel_CG3066 GN {ECO:0000313|EMBL:AAF54143.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF43410.1} RP NUCLEOTIDE SEQUENCE. RA Ryu J.H., Lee W.J.; RT "Molecular cloning of a Drosophila serine proteinase homologous to RT easter."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [6] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF54143.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF54143.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF54143.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF54143.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the peptidase S1 family. CC {ECO:0000256|RuleBase:RU000360}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF233093; AAF43410.1; -; mRNA. DR EMBL; AE014297; AAF54143.1; -; Genomic_DNA. DR EMBL; AE014297; AAG22126.1; -; Genomic_DNA. DR EMBL; AE014297; AAG22127.2; -; Genomic_DNA. DR RefSeq; NP_649734.2; NM_141477.2. DR RefSeq; NP_731174.1; NM_169192.3. DR RefSeq; NP_731175.2; NM_169193.3. DR UniGene; Dm.6983; -. DR MINT; MINT-336596; -. DR STRING; 7227.FBpp0081237; -. DR MEROPS; S01.203; -. DR EnsemblMetazoa; FBtr0081740; FBpp0081237; FBgn0037515. DR EnsemblMetazoa; FBtr0339180; FBpp0308321; FBgn0037515. DR EnsemblMetazoa; FBtr0339181; FBpp0308322; FBgn0037515. DR GeneID; 40918; -. DR KEGG; dme:Dmel_CG3066; -. DR UCSC; CG3066-RA; d. melanogaster. DR UCSC; CG3066-RB; d. melanogaster. DR CTD; 121340; -. DR FlyBase; FBgn0037515; Sp7. DR eggNOG; COG5640; LUCA. DR eggNOG; KOG3627; Eukaryota. DR GeneTree; ENSGT00720000108964; -. DR OMA; FATRNIH; -. DR GenomeRNAi; 40918; -. DR NextBio; 821269; -. DR Proteomes; UP000000803; Chromosome 3R. DR GO; GO:0005576; C:extracellular region; IDA:FlyBase. DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0004252; F:serine-type endopeptidase activity; ISM:FlyBase. DR GO; GO:0035006; P:melanization defense response; IMP:FlyBase. DR GO; GO:0035008; P:positive regulation of melanization defense response; IMP:FlyBase. DR GO; GO:0006508; P:proteolysis; ISM:FlyBase. DR InterPro; IPR022700; CLIP. DR InterPro; IPR006604; Disulphide_knot_CLIP. DR InterPro; IPR018114; Peptidase_S1_AS. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR001254; Trypsin_dom. DR Pfam; PF12032; CLIP; 1. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00680; CLIP; 1. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 1: Evidence at protein level; KW Carboxypeptidase {ECO:0000313|EMBL:AAF54143.1}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Hydrolase {ECO:0000256|RuleBase:RU004260, KW ECO:0000313|EMBL:AAF54143.1}; KW Protease {ECO:0000256|RuleBase:RU004260, ECO:0000313|EMBL:AAF54143.1}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q9V3Z2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Serine protease {ECO:0000256|RuleBase:RU004260}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 391 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005706275. FT DOMAIN 137 390 Peptidase S1. {ECO:0000259|PROSITE: FT PS50240}. SQ SEQUENCE 391 AA; 43128 MW; 3E1416F12EDF89F6 CRC64; MKSTRKVVGI FLATCLLPFT VLQNVAAQGS CRNPNQKQGQ CLSIYDCQSL LSVIQQSYVS PEDRTFLRNS QCLDGVGRQP YVCCTSDRSF GSQEATSAAP PPTTTSSSSR GQDGQAGLGN LLPSPPKCGP HSFSNKVYNG NDTAIDEFNW MALLEYVDNR GRRELSCGGS LINNRYVLTA AHCVIGAVET EVGHLTTVRL GEYDTSKDVD CIDDICNQPI LQLGIEQATV HPQYDPANKN RIHDIALLRL DRPVVLNEYI QPVCLPLVST RMAINTGELL VVSGWGRTTT ARKSTIKQRL DLPVNDHDYC ARKFATRNIH LISSQLCVGG EFYRDSCDGD SGGPLMRRGF DQAWYQEGVV SFGNRCGLEG WPGVYTRVAD YMDWIVETIR P //