ID THYX_PYRAB STANDARD; PRT; 244 AA. AC Q9UZ51; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Thymidylate synthase thyX (EC 2.1.1.148) (TS) (TSase). GN Name=thyX; OrderedLocusNames=PYRAB13030; ORFNames=PAB0861; OS Pyrococcus abyssi. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=29292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GE5 / Orsay; RX MEDLINE=22511545; PubMed=12622808; RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., RA Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.; RT "An integrated analysis of the genome of the hyperthermophilic RT archaeon Pyrococcus abyssi."; RL Mol. Microbiol. 47:1495-1512(2003). CC -!- FUNCTION: Catalyzes the formation of dTMP and tetrahydrofolate CC from dUMP and methylenetetrahydrofolate (By similarity). CC -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP + CC FADH(2) = dTMP + tetrahydrofolate + FAD. CC -!- COFACTOR: Binds 1 FAD per subunit (By similarity). CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SIMILARITY: Belongs to the thymidylate synthase thyX family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ248287; CAB50208.1; -. DR PIR; C75039; C75039. DR HSSP; Q9WYT0; 1KQ4. DR HAMAP; MF_01408; -; 1. DR InterPro; IPR003669; Thy1. DR Pfam; PF02511; Thy1; 1. KW Complete proteome; FAD; Flavoprotein; Methyltransferase; KW Nucleotide biosynthesis; Transferase. FT SITE 80 90 ThyX motif. SQ SEQUENCE 244 AA; 29193 MW; BD54D9AB170222BD CRC64; MVRVTLVNYT RRPLETITWA ALVSYWDEWS TESFEKINED DVKAHLPRIL GYGHESILEH ATFTFSIEGC SRVCTHQLVR HRIASYTQQS QRYIVLNEEN VEETFVIPES IKKDRELYEK WKKAMAETIK LYKESLKRGI HQEDARFILP QAVRSKIVVT MNLRELKHFF GLRLCERAQW EIREVAWKML EEIAKREELR PIIKWAKLGP RCIQLGYCPE RELMPPGCFK RTRERWMKLL EKPL //