ID   VORA_PYRAB              Reviewed;         395 AA.
AC   Q9UYZ1; G8ZHH2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAY-2015, entry version 87.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit VorA;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit alpha;
DE   AltName: Full=2-oxoisovalerate oxidoreductase alpha chain;
GN   Name=vorA; OrderedLocusNames=PYRAB13660; ORFNames=PAB1472;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C.,
RA   Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic
RT   archaeon Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5
RT   and Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one
CC       gamma chain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ248287; CAB50271.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70809.1; -; Genomic_DNA.
DR   PIR; B75047; B75047.
DR   RefSeq; NP_127041.1; NC_000868.1.
DR   RefSeq; WP_010868481.1; NC_000868.1.
DR   ProteinModelPortal; Q9UYZ1; -.
DR   STRING; 272844.PAB1472; -.
DR   EnsemblBacteria; CAB50271; CAB50271; PAB1472.
DR   GeneID; 1496755; -.
DR   KEGG; pab:PAB1472; -.
DR   eggNOG; COG0674; -.
DR   HOGENOM; HOG000230983; -.
DR   KO; K00186; -.
DR   OMA; YEFRYKI; -.
DR   Proteomes; UP000000810; Chromosome.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/Pyr-ferredox_oxred.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   4: Predicted;
KW   Complete proteome; Oxidoreductase.
FT   CHAIN         1    395       Ketoisovalerate oxidoreductase subunit
FT                                VorA.
FT                                /FTId=PRO_0000099951.
SQ   SEQUENCE   395 AA;  44230 MW;  DF760EDF08CB6823 CRC64;
     MVEYKPIKKV VSGNYAAAYA VLHARVQVVA AYPITPQTSI IEKIAEFIAN GEADIQYIPV
     ESEHSAMAAC IGASATGARV FTATSAQGLA LMHEMLHWAA GARLPIVMVD VNRAMAPPWS
     VWDDQTDSLS QRDTGWMQFY AENNQEVYDG VLMAFKVAET VNVPAMVVES AFILSHTYEI
     VNMIPQELVD EFLPPRKPLY SLADFENPIA VGALATPADY YEFRYKLARA HEEAKKVIKD
     VGREFGERFG RDYSEMIEKA YIDDADFVFM GMGSLMGTVK EAVELLRKQG YKVGYAKVRW
     FRPFPREELL EIAESVKGIA VLDRNFSFGQ EGILFTEAKG ALYNNGARPI MKNYIVGLGG
     RDFTVSDVKA IAEDMKKVIE SGKLDREVEW YHLKR
//