ID VORA_PYRAB Reviewed; 395 AA. AC Q9UYZ1; DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 05-OCT-2010, entry version 58. DE RecName: Full=Ketoisovalerate oxidoreductase subunit vorA; DE Short=VOR; DE EC=1.2.7.7; DE AltName: Full=2-oxoisovalerate ferredoxin reductase subunit alpha; DE AltName: Full=2-oxoisovalerate oxidoreductase alpha chain; GN Name=vorA; OrderedLocusNames=PYRAB13660; ORFNames=PAB1472; OS Pyrococcus abyssi. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=29292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GE5 / Orsay; RX MEDLINE=22511545; PubMed=12622808; RX DOI=10.1046/j.1365-2958.2003.03381.x; RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., RA Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.; RT "An integrated analysis of the genome of the hyperthermophilic RT archaeon Pyrococcus abyssi."; RL Mol. Microbiol. 47:1495-1512(2003). CC -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized CC ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced CC ferredoxin + H(+). CC -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one CC gamma chain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ248287; CAB50271.1; -; Genomic_DNA. DR PIR; B75047; B75047. DR RefSeq; NP_127041.1; -. DR ProteinModelPortal; Q9UYZ1; -. DR EnsemblBacteria; EBPYRT00000002287; EBPYRP00000002218; EBPYRG00000002287. DR GeneID; 1496755; -. DR GenomeReviews; AL096836_GR; PYRAB13660. DR KEGG; pab:PAB1472; -. DR NMPDR; fig|272844.1.peg.1448; -. DR HOGENOM; HBG313202; -. DR OMA; EGILFTE; -. DR ProtClustDB; PRK08366; -. DR BioCyc; PABY272844:PAB1472-MONOMER; -. DR BRENDA; 1.2.7.7; 262861. DR GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N. DR InterPro; IPR009014; Transketo_C/Pyr-ferredox_oxred. DR InterPro; IPR015941; Transketolase-like_C. DR Gene3D; G3DSA:3.40.50.920; Transketo_C_like; 1. DR Pfam; PF01855; POR_N; 1. DR SUPFAM; SSF52922; Transketo_C_like; 1. PE 4: Predicted; KW Complete proteome; Oxidoreductase. FT CHAIN 1 395 Ketoisovalerate oxidoreductase subunit FT vorA. FT /FTId=PRO_0000099951. SQ SEQUENCE 395 AA; 44230 MW; DF760EDF08CB6823 CRC64; MVEYKPIKKV VSGNYAAAYA VLHARVQVVA AYPITPQTSI IEKIAEFIAN GEADIQYIPV ESEHSAMAAC IGASATGARV FTATSAQGLA LMHEMLHWAA GARLPIVMVD VNRAMAPPWS VWDDQTDSLS QRDTGWMQFY AENNQEVYDG VLMAFKVAET VNVPAMVVES AFILSHTYEI VNMIPQELVD EFLPPRKPLY SLADFENPIA VGALATPADY YEFRYKLARA HEEAKKVIKD VGREFGERFG RDYSEMIEKA YIDDADFVFM GMGSLMGTVK EAVELLRKQG YKVGYAKVRW FRPFPREELL EIAESVKGIA VLDRNFSFGQ EGILFTEAKG ALYNNGARPI MKNYIVGLGG RDFTVSDVKA IAEDMKKVIE SGKLDREVEW YHLKR //