ID DHSA_SCHPO Reviewed; 641 AA. AC Q9UTJ7; P78912; DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 31-OCT-2006, entry version 43. DE Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, DE mitochondrial precursor (EC 1.3.5.1) (FP) (Flavoprotein subunit of DE complex II). GN Name=sdh1; ORFNames=SPAC1556.02c; OS Schizosaccharomyces pombe (Fission yeast). OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; OC Schizosaccharomyces. OX NCBI_TaxID=4896; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 38366 / 972; RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-641. RC STRAIN=PR745; RX MEDLINE=98162722; PubMed=9501991; DOI=10.1093/dnares/4.6.363; RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.; RT "Identification of open reading frames in Schizosaccharomyces pombe RT cDNAs."; RL DNA Res. 4:363-369(1997). CC -!- CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol. CC -!- COFACTOR: FAD (By similarity). CC -!- PATHWAY: Tricarboxylic acid cycle. CC -!- SUBUNIT: Forms part of complex II containing four subunits: a CC flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b CC composed of two integral membrane proteins (By similarity). CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial inner membrane CC (By similarity). CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. CC FRD/SDH subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL132984; CAB61213.1; -; Genomic_DNA. DR EMBL; D89263; BAA13924.1; -; mRNA. DR PIR; T50081; T50081. DR HSSP; P10444; 1NEK. DR GeneDB_Spombe; SPAC1556.02c; -. DR BioCyc; SPOM-XXX-01:SPOM-XXX-01-002428-MONOMER; -. DR ArrayExpress; Q9UTJ7; -. DR GO; GO:0005739; C:mitochondrion; IDA:GeneDB_SPombe. DR InterPro; IPR003953; FAD_bind2_N. DR InterPro; IPR013027; FAD_pyr_redox. DR InterPro; IPR003952; FRD_SDH_FAD_BS. DR InterPro; IPR001100; Pyr_redox. DR InterPro; IPR011281; SDH_A_forward. DR InterPro; IPR014006; SdhA_frdA_Gneg. DR InterPro; IPR004112; Succ_DH_flav_C. DR Pfam; PF00890; FAD_binding_2; 1. DR Pfam; PF02910; Succ_DH_flav_C; 1. DR PRINTS; PR00368; FADPNR. DR PRINTS; PR00411; PNDRDTASEI. DR TIGRFAMs; TIGR01816; sdhA_forward; 1. DR PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1. KW Complete proteome; Electron transport; FAD; Flavoprotein; KW Hypothetical protein; Mitochondrion; Oxidoreductase; Transit peptide; KW Transport; Tricarboxylic acid cycle. FT TRANSIT 1 ? Mitochondrion (Potential). FT CHAIN ? 641 Probable succinate dehydrogenase FT [ubiquinone] flavoprotein subunit. FT /FTId=PRO_0000010341. FT NP_BIND 57 71 FAD (Potential). FT ACT_SITE 289 289 By similarity. FT ACT_SITE 305 305 By similarity. FT MOD_RES 92 92 Tele-8alpha-FAD histidine (By FT similarity). FT CONFLICT 214 214 A -> G (in Ref. 2). FT CONFLICT 218 218 I -> L (in Ref. 2). SQ SEQUENCE 641 AA; 70466 MW; 5E5FCD857C372199 CRC64; MLRFRKVAPS LKNGGNLKLF STSSTLKKIA SSQPLRAKQV STSESVKYPV IDHTYDAIVV GAGGAGLRAT FGLAEAGFNT ACITKLFPTR SHTVAAQGGI NAALGNMTKD DWRWHFYDTV KGSDWLGDQD AIHYMTKEAP KAVLELEHFG VPFSRTKEGK IYQRAFGGQS LEYGKGGQAY RCAAVADRTG HSILHTLYGQ SLKHNTNFFI EYFAMDLIME GGECRGVIAM NLEDGSIHRF RAHKTILATG GYGRAYFSCT SAHTCTGDGN AMVSRAGLPL QDLEFVQFHP TGIYGAGCLI TEGCRGEGGY LLNSKGERFM ERYAPTAKDL ASRDVVSRAM TVEIREGRGV GPEKDHCYLQ LSHLPAEILK ERLPGISETA AIFAGVDVTK EPIPVLPTVH YNMGGIPTRF TGEVLTIDEN GKDKIVPGLY AAGEAACVSV HGGNRLGANS LLDIVVFGRA CALHIKDTLE PNTPHKPLAA DAGLDSLKFL DQIRTSQGPK HTSEIRLDMQ KTMQRDVSVF RMEETLQEGV KNIARVDGTY KDIGIRDRGL IWNTDLVEAL ELRNLLTCAV QTANAALNRK ESRGAHARED YPERDDKNWI KHTLTWQHKT GDPVTLKYRA VTRTTMDENE VKPVPPFKRV Y //