ID DHSA_SCHPO STANDARD; PRT; 641 AA. AC Q9UTJ7; P78912; DT 15-SEP-2003 (Rel. 42, Created) DT 15-SEP-2003 (Rel. 42, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, DE mitochondrial precursor (EC 1.3.5.1) (FP) (Flavoprotein subunit of DE complex II). GN SDH1 OR SPAC1556.02C. OS Schizosaccharomyces pombe (Fission yeast). OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; OC Schizosaccharomyces. OX NCBI_TaxID=4896; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=972; RX MEDLINE=21848401; PubMed=11859360; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M., Lyne R., Stewart A., RA Sgouros J., Peat N., Hayles J., Baker S., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., RA Gentles S., Goble A., Hamlin N., Harris D., Hidalgo J., Hodgson G., RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., RA James K., Jones L., Jones M., Leather S., McDonald S., McLean J., RA Mooney P., Moule S., Mungall K., Murphy L., Niblett D., Odell C., RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., RA Rutherford K., Rutter S., Saunders D., Seeger K., Sharp S., RA Skelton J., Simmonds M., Squares R., Squares S., Stevens K., RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., RA Woodward J., Volckaert G., Aert R., Robben J., Grymonprez B., RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Fritzc C., Holzer E., Moestl D., Hilbert H., RA Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., RA Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., RA Cerrutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). RN [2] RP SEQUENCE OF 155-641 FROM N.A. RC STRAIN=PR745; RX MEDLINE=98162722; PubMed=9501991; RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.; RT "Identification of open reading frames in Schizosaccharomyces pombe RT cDNAs."; RL DNA Res. 4:363-369(1997). CC -!- CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol. CC -!- COFACTOR: FAD (By similarity). CC -!- PATHWAY: Tricarboxylic acid cycle. CC -!- SUBUNIT: Forms part of complex II containing four subunits: a 70 CC kDa flavoprotein (FP), a 27 kDa iron-sulfur protein (IP), a CC cytochrome B and a membrane-anchoring protein (By similarity). CC -!- SUBCELLULAR LOCATION: Mitochondrial inner membrane (By CC similarity). CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family 2. CC FRD/SDH subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL132984; CAB61213.1; -. DR EMBL; D89263; BAA13924.1; -. DR PIR; T50081; T50081. DR HSSP; P00363; 1KF6. DR GeneDB_SPombe; SPAC1556.02c; -. DR InterPro; IPR003953; FAD_bind2. DR InterPro; IPR001327; FAD_pyr_redox. DR InterPro; IPR003952; FRD/SDH_FAD_BS. DR InterPro; IPR001100; Pyr_redox. DR InterPro; IPR004112; Succ_DH_flav_C. DR Pfam; PF00890; FAD_binding_2; 1. DR Pfam; PF02910; succ_DH_flav_C; 1. DR PRINTS; PR00368; FADPNR. DR PRINTS; PR00411; PNDRDTASEI. DR PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1. KW Hypothetical protein; Tricarboxylic acid cycle; Flavoprotein; FAD; KW Oxidoreductase; Electron transport; Mitochondrion; Transit peptide. FT TRANSIT 1 ? MITOCHONDRION (POTENTIAL). FT CHAIN ? 641 PROBABLE SUCCINATE DEHYDROGENASE FT [UBIQUINONE] FLAVOPROTEIN SUBUNIT. FT NP_BIND 57 71 FAD (AMP PART) (POTENTIAL). FT BINDING 92 92 FAD (COVALENT) (BY SIMILARITY). FT ACT_SITE 289 289 BY SIMILARITY. FT ACT_SITE 305 305 BY SIMILARITY. FT CONFLICT 214 214 A -> G (IN REF. 2). FT CONFLICT 218 218 I -> L (IN REF. 2). SQ SEQUENCE 641 AA; 70466 MW; 5E5FCD857C372199 CRC64; MLRFRKVAPS LKNGGNLKLF STSSTLKKIA SSQPLRAKQV STSESVKYPV IDHTYDAIVV GAGGAGLRAT FGLAEAGFNT ACITKLFPTR SHTVAAQGGI NAALGNMTKD DWRWHFYDTV KGSDWLGDQD AIHYMTKEAP KAVLELEHFG VPFSRTKEGK IYQRAFGGQS LEYGKGGQAY RCAAVADRTG HSILHTLYGQ SLKHNTNFFI EYFAMDLIME GGECRGVIAM NLEDGSIHRF RAHKTILATG GYGRAYFSCT SAHTCTGDGN AMVSRAGLPL QDLEFVQFHP TGIYGAGCLI TEGCRGEGGY LLNSKGERFM ERYAPTAKDL ASRDVVSRAM TVEIREGRGV GPEKDHCYLQ LSHLPAEILK ERLPGISETA AIFAGVDVTK EPIPVLPTVH YNMGGIPTRF TGEVLTIDEN GKDKIVPGLY AAGEAACVSV HGGNRLGANS LLDIVVFGRA CALHIKDTLE PNTPHKPLAA DAGLDSLKFL DQIRTSQGPK HTSEIRLDMQ KTMQRDVSVF RMEETLQEGV KNIARVDGTY KDIGIRDRGL IWNTDLVEAL ELRNLLTCAV QTANAALNRK ESRGAHARED YPERDDKNWI KHTLTWQHKT GDPVTLKYRA VTRTTMDENE VKPVPPFKRV Y //