ID   Q9URM3_PICAN            Unreviewed;      1044 AA.
AC   Q9URM3;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   03-OCT-2012, entry version 63.
DE   SubName: Full=Nitrite reductase;
DE            EC=1.7.99.3;
GN   Name=YNI1;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetales incertae sedis;
OC   Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=95309418; PubMed=7789531; DOI=10.1016/0014-5793(95)00511-7;
RA   Avila J., Perez M.D., Brito N., Gonzalez C., Siverio J.M.;
RT   "Cloning and disruption of the YNR1 gene encoding the nitrate
RT   reductase apoenzyme of the yeast Hansenula polymorpha.";
RL   FEBS Lett. 366:137-142(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Brito N., Avila J., Perez M., Gonzalez C., Siverio J.;
RT   "The genes YNI1 and YNR1, encoding nitrite reductase and nitrate
RT   reductase respectively in the yeast Hansenula polymorpha, are
RT   clustered and coordinately regulated.";
RL   Biochem. J. 317:89-95(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97173004; PubMed=9020872;
RA   Perez M.D., Gonzalez C., Avila J., Brito N., Siverio J.M.;
RT   "The YNT1 gene encoding the nitrate transporter in the yeast Hansenula
RT   polymorpha is clustered with genes YNI1 and YNR1 encoding nitrite
RT   reductase and nitrate reductase, and its disruption causes inability
RT   to grow in nitrate.";
RL   Biochem. J. 321:397-403(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RA   Avila J., Gonzalez C., Brito N., Siverio J.M.;
RT   "Clustering of the YNA1 gene encoding a Zn(II)2Cys6 transcriptional
RT   factor in the yeast Hansenula polymorpha with the nitrate assimilation
RT   genes YNT1, YNI1 and YNR1 and its involvment in their transcriptional
RT   activation.";
RL   Biochem. J. 335:647-652(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RA   Avila J., Gonzalez C., Brito N., Machin F., Perez M., Siverio J.;
RT   "A second Zn(II)cCys6 transcriptional factor encoded by the YNA2 gene
RT   is indispensable for nitrate induction of the genes involved in
RT   nitrate assimilation in the yeast Hansenula polymorpha.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RA   Siverio J.M.;
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Contains 1 Rieske domain.
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DR   EMBL; AJ223294; CAA11230.1; -; Genomic_DNA.
DR   PIR; T43155; T43155.
DR   ProteinModelPortal; Q9URM3; -.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0008942; F:nitrite reductase [NAD(P)H] activity; IEA:InterPro.
DR   GO; GO:0042128; P:nitrate assimilation; IEA:InterPro.
DR   Gene3D; G3DSA:3.90.480.10; G3DSA:3.90.480.10; 1.
DR   Gene3D; G3DSA:2.102.10.10; Rieske_reg; 1.
DR   InterPro; IPR007419; BFD-like_2Fe2S-bd_dom.
DR   InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase.
DR   InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR   InterPro; IPR012744; Nitri_red_NirB.
DR   InterPro; IPR012748; Nitri_red_NirD.
DR   InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR   InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR   InterPro; IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
DR   InterPro; IPR001327; Pyr_OxRdtase_NAD-bd_dom.
DR   InterPro; IPR017941; Rieske_2Fe-2S.
DR   Pfam; PF04324; Fer2_BFD; 1.
DR   Pfam; PF01077; NIR_SIR; 1.
DR   Pfam; PF03460; NIR_SIR_ferr; 1.
DR   Pfam; PF00070; Pyr_redox; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF00355; Rieske; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00397; SIROHAEM.
DR   SUPFAM; SSF55124; NiR_SiRalpha_1/3; 1.
DR   SUPFAM; SSF50022; Rieske_dom; 1.
DR   TIGRFAMs; TIGR02378; nirD_assim_sml; 1.
DR   TIGRFAMs; TIGR02374; nitri_red_nirB; 1.
DR   PROSITE; PS00365; NIR_SIR; 1.
DR   PROSITE; PS51296; RIESKE; 1.
PE   4: Predicted;
KW   2Fe-2S; Iron; Iron-sulfur; Metal-binding; Oxidoreductase.
SQ   SEQUENCE   1044 AA;  116642 MW;  F946D5C52889EB4F CRC64;
     MTCSVPPLPE DISPRAAKKK LVIVGLGMVG LSFLEKLLSN DSKLNEYSIM VYGEEPYLAY
     NRVGLTEYFQ HREFKNLLLS PEEFYQLRGE KWNYAIDEKV VDIDRRARII TTDKGNRASY
     DVLVLCTGSA AILPTDLLPP LTRKSYREMG CFVYRTIDDL YSMIDYCQGA KKTRAIVVGG
     GLLGLEAAKA LYDMESFEDI TIVHRSHWLL SQQMDQKGGS LLTSKVKELG ITCRTGTTVS
     ELLFDEDQNL KGVKYDNGQI EECSLLCYTI GIKPRDELTS CGLNAGSRGG FKVNNMLQTS
     DENIYAIGEC ASWNNMTFGL IAPGYEMADI LAFNLTQGKL HQPKEFSEPS MGTRLKLMGV
     DVASFGDFFA DRNGPKWLLA DTTKKFVDLV FEDPIDATYT KLLFTKDGKY MLGGILVGDT
     SNYTKFSAMI RKPLPKSPSE LLIGKSGEDD MEMLSDETQI CSCHNITKGK LVEAVKNGCS
     SLADVKKCTK AGTACGGCEP TVKIIFEKEL KKLGGKVSNN LCVHFDYSRA HWFSLIMVKN
     FRSFRRVMEE LGNDPSSSGC EICKPTIGSI LSTLYNRHLL KKEVHGLQDT NDRYLGNIQR
     DGTFSVVPRM SAGEITPEKL VSIGKIAKKY GVYTKITGAQ RLDLFGVKKS DLLKIWKDLN
     EAGFESGQAY GKSLRNVKSC VGSTWCRYGI GDSVGLAVRL EERYKGIRSP HKMKGGVSGC
     VRDCAEFHSK DFGLCAVSGG FNIYVGGNGG MKPRHAQLLA TNVRPDEVIP ILDRYLMFYI
     TTADRLQRTA RWLENLDGGI EYLKDVIIRD KLGICKDLEA QMRHVVAGYY DEWAKAVSEE
     KENPIFKQFV NTPENQDCVE IVNERGQPRP AMWPEKAANQ KFNEIRWSSV SWQEVCECSD
     LPLAEAGSSA TVLVGDTQIA LFRTSKNELY CSQNMCGHKR AFVLNQGLLS EDSDKNCYIS
     CPMHKRNFYL KSGACKNDEA LSIATFEVKE ENGKVYAKLP PLKELDEVLG TSKWKVTSQE
     TEAKQVRKIT TEKNLVDKAI LLDW
//