ID   DICE_HUMAN     STANDARD;      PRT;  1912 AA.
AC   Q9UPY3; O95943; Q9UQ02;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   28-FEB-2003 (Rel. 41, Last annotation update)
DE   Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif)
DE   (Helicase-MOI).
GN   DICER1 OR DICER OR HERNA OR KIAA0928.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20246304; PubMed=10786632;
RA   Matsuda S., Ichigotani Y., Okuda T., Irimura T., Nakatsugawa S.,
RA   Hamaguchi M.;
RT   "Molecular cloning and characterization of a novel human gene (HERNA)
RT   which encodes a putative RNA-helicase.";
RL   Biochim. Biophys. Acta 1490:163-169(2000).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Lung;
RA   Provost P., Dishart D., Doucet D., Hermansson A., Frendewey D.,
RA   Samuelsson B., Radmark O.;
RT   "RNA binding and processing by recombinant human Dicer.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=99246063; PubMed=10231032;
RA   Nagase T., Ishikawa K.-I., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 6:63-70(1999).
RN   [4]
RP   REVISIONS.
RX   MEDLINE=22158633; PubMed=12168954;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [5]
RP   SEQUENCE OF 1238-1912 FROM N.A.
RC   TISSUE=Lung;
RX   MEDLINE=99162526; PubMed=10051563;
RA   Provost P., Samuelsson B., Radmark O.;
RT   "Interaction of 5-lipoxygenase with cellular proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:1881-1885(1999).
CC   -!- FUNCTION: Involved in cleaving double-stranded RNA in the RNA
CC       interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs
CC       (siRNAs) which target the selective destruction of homologous
CC       RNAs.
CC   -!- SIMILARITY: Belongs to the helicase family.
CC   -!- SIMILARITY: Contains 2 RNase III domains.
CC   -!- SIMILARITY: Contains 1 PAZ domain.
CC   -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
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DR   EMBL; AB028449; BAA78691.1; ALT_INIT.
DR   EMBL; AJ132261; CAB38857.2; -.
DR   EMBL; AB023145; BAA76772.2; ALT_INIT.
DR   Genew; HGNC:17098; DICER1.
DR   MIM; 606241; -.
DR   InterPro; IPR001410; DEAD.
DR   InterPro; IPR001159; DS_RBD.
DR   InterPro; IPR005034; DUF283.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR003100; PAZ.
DR   InterPro; IPR000999; RNase_3.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF03368; DUF283; 1.
DR   Pfam; PF00271; helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
KW   Helicase; ATP-binding; RNA-binding; Hydrolase; Nuclease; Endonuclease;
KW   Repeat.
FT   NP_BIND      34     41       ATP (POTENTIAL).
FT   SITE        165    168       DECH BOX.
FT   DOMAIN      881   1032       PAZ.
FT   DOMAIN     1266   1393       RNASE III 1.
FT   DOMAIN     1656   1814       RNASE III 2.
FT   DOMAIN     1839   1904       DRBM.
FT   CONFLICT     65     80       VLLTKELSYQIRGDFS -> STTLLKSCLYLDLGETSA
FT                                (IN REF. 1).
FT   CONFLICT    179    179       I -> F (IN REF. 1).
FT   CONFLICT    185    185       N -> I (IN REF. 1).
FT   CONFLICT    204    204       C -> W (IN REF. 1).
FT   CONFLICT    208    208       E -> D (IN REF. 1).
FT   CONFLICT    213    213       I -> F (IN REF. 1).
FT   CONFLICT    383    384       QQ -> HS (IN REF. 1).
FT   CONFLICT    482    483       KQ -> NT (IN REF. 1).
FT   CONFLICT    599    599       D -> H (IN REF. 1).
SQ   SEQUENCE   1912 AA;  217627 MW;  996399DB4B074F21 CRC64;
     MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT IVCLNTGSGK
     TFIAVLLTKE LSYQIRGDFS RNGKRTVFLV NSANQVAQQV SAVRTHSDLK VGEYSNLEVN
     ASWTKERWNQ EFTKHQVLIM TCYVALNVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM
     KLCENCPSCP RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL VVLDRYTSQP
     CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK QILSDCRAVL
     VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT FLRKIHALCE EHFSPASLDL
     KFVTPKVIKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDE DEEIEEKEKP
     ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR
     NKQMEAEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP TEYRSYVQSK
     GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGETD IDPVMDDDDV
     FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD GTFYSTLYLP
     INSPLRASIV GPPMSCVRLA ERVVALICCE KLHKIGELDD HLMPVGKETV KYEEELDLHD
     EEETSVPGRP GSTKRRQCYP KAIPECLRDS YPRPDQPCYL YVIGMVLTTP LPDELNFRRR
     KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFMLSL QMLELITRLH
     QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI EKSEARIGIP
     STKYTKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF PSPEYETFAE
     YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR KAKWESLQNK
     QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPADFR
     YPNLDFGWKK SIDSKSFISI SNSSSAENDN YCKHSTIVPE NAAHQGANRT SSLENHDQMS
     VNCRTLLSES PGKLHVEVSA DLTAINGLSY NQNLANGSYD LANRDFCQGN QLNYYKQEIP
     VQPTTSYSIQ NLYSYENQPQ PSDECTLLSN KYLDGNANKS TSDGSPVMAV MPGTTDTIQV
     LKGRMDSEQS PSIGYSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD SFLKHAITTY
     LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD
     KSNTDKWEKD EMTKDCMLAN GKLDEDYEEE DEEEESLMWR APKEEADYED DFLEYDQEHI
     RFIDNMLMGS GAFVKKISLS PFSTTDSAYE WKMPKKSSLG SMPFSSDFED FDYSSWDAMC
     YLDPSKAVEE DDFVVGFWNP SEENCGVDTG KQSISYDLHT EQCIADKSIA DCVEALLGCY
     LTSCGERAAQ LFLCSLGLKV LPVIKRTDRE KALCPTRENF NSQQKNLSVS CAAASVASSR
     SSVLKDSEYG CLKIPPRCMF DHPDADKTLN HLISGFENFE KKINYRFKNK AYLLQAFTHA
     SYHYNTITDC YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV NNTIFASLAV
     KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE DIEVPKAMGD
     IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP RSPVRELLEM EPETAKFSPA
     ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA KSAAARRALR SLKANQPQVP NS
//