ID FLVC2_HUMAN Reviewed; 526 AA. AC Q9UPI3; Q96JY3; Q9NX90; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 29-MAY-2007, entry version 44. DE Feline leukemia virus subgroup C receptor-related protein 2 (Calcium- DE chelate transporter) (CCT). GN Name=FLVCR2; Synonyms=C14orf58; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RC TISSUE=Pituitary; RX PubMed=14729055; DOI=10.1016/j.yexcr.2003.10.002; RA Brasier G., Tikellis C., Xuereb L., Craigie J., Casley D., RA Kovacs C.S., Fudge N.J., Kalnins R., Cooper M.E., Wookey P.J.; RT "Novel hexad repeats conserved in a putative transporter with RT restricted expression in cell types associated with growth, calcium RT exchange and homeostasis."; RL Exp. Cell Res. 293:31-42(2004). RN [2] RP NUCLEOTIDE SEQUENCE. RA Brown J., Pirani H., Tailor C.S.; RT "An aspartic acid in the presumptive extracellular loop six of RT subgroup C feline leukemia virus receptor FLVCR1 is involved in virus RT infection."; RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-16. RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22459283; PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Transporter specific for a calcium-chelator complex, CC important for growth and calcium metabolism. CC -!- SUBCELLULAR LOCATION: Cell membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Found in acidophil cells of the pituitary that CC secrete growth hormone and prolactin. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Feline CC leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY260572; AAP86633.1; -; mRNA. DR EMBL; AF456126; AAO15528.1; -; mRNA. DR EMBL; AK000378; BAA91126.1; -; mRNA. DR EMBL; AK027804; BAB55381.1; ALT_INIT; mRNA. DR EMBL; AC007182; AAD51374.1; -; Genomic_DNA. DR EMBL; BC019087; AAH19087.1; -; mRNA. DR UniGene; Hs.509966; -. DR UniGene; Hs.615289; -. DR Ensembl; ENSG00000119686; Homo sapiens. DR KEGG; hsa:55640; -. DR HGNC; HGNC:20105; FLVCR2. DR MIM; 610865; gene. DR ArrayExpress; Q9UPI3; -. DR GermOnline; ENSG00000119686; Homo sapiens. DR RZPD-ProtExp; IOH13938; -. DR RZPD-ProtExp; RZPDo834H0144; -. DR RZPD-ProtExp; W1512; -. DR InterPro; IPR007114; MFS. DR InterPro; IPR011701; MFS_1. DR Pfam; PF07690; MFS_1; 1. DR PROSITE; PS50850; MFS; 1. KW Membrane; Polymorphism; Repeat; Transmembrane; Transport. FT CHAIN 1 526 Feline leukemia virus subgroup C FT receptor-related protein 2. FT /FTId=PRO_0000084846. FT TRANSMEM 103 123 Potential. FT TRANSMEM 125 145 Potential. FT TRANSMEM 152 172 Potential. FT TRANSMEM 176 196 Potential. FT TRANSMEM 217 237 Potential. FT TRANSMEM 252 272 Potential. FT TRANSMEM 310 330 Potential. FT TRANSMEM 349 369 Potential. FT TRANSMEM 386 406 Potential. FT TRANSMEM 407 427 Potential. FT TRANSMEM 436 456 Potential. FT TRANSMEM 471 491 Potential. FT REPEAT 25 30 1. FT REPEAT 31 36 2. FT REPEAT 37 42 3. FT REPEAT 43 48 4. FT REPEAT 49 54 5. FT REPEAT 55 60 6; approximate. FT REPEAT 61 66 7; approximate. FT REPEAT 67 72 8. FT REGION 25 72 8 X 6 AA tandem repeats of P-S-[VS]-S- FT [VIAG]-[HNP]. FT COMPBIAS 507 511 Poly-Glu. FT VARIANT 16 16 V -> A (in dbSNP:rs2287015). FT /FTId=VAR_018271. FT CONFLICT 419 419 L -> H (in Ref. 3; BAB55381). FT CONFLICT 439 439 S -> F (in Ref. 3; BAA91126). SQ SEQUENCE 526 AA; 57241 MW; D233C07350B17870 CRC64; MVNEGPNQEE SDDTPVPESA LQADPSVSVH PSVSVHPSVS INPSVSVHPS SSAHPSALAQ PSGLAHPSSS GPEDLSVIKV SRRRWAVVLV FSCYSMCNSF QWIQYGSINN IFMHFYGVSA FAIDWLSMCY MLTYIPLLLP VAWLLEKFGL RTIALTGSAL NCLGAWVKLG SLKPHLFPVT VVGQLICSVA QVFILGMPSR IASVWFGANE VSTACSVAVF GNQLGIAIGF LVPPVLVPNI EDRDELAYHI SIMFYIIGGV ATLLLILVII VFKEKPKYPP SRAQSLSYAL TSPDASYLGS IARLFKNLNF VLLVITYGLN AGAFYALSTL LNRMVIWHYP GEEVNAGRIG LTIVIAGMLG AVISGIWLDR SKTYKETTLV VYIMTLVGMV VYTFTLNLGH LWVVFITAGT MGFFMTGYLP LGFEFAVELT YPESEGISSG LLNISAQVFG IIFTISQGQI IDNYGTKPGN IFLCVFLTLG AALTAFIKAD LRRQKANKET LENKLQEEEE ESNTSKVPTA VSEDHL //