ID   FLVC2_HUMAN             Reviewed;         526 AA.
AC   Q9UPI3; B7Z485; Q53ZT9; Q96JY3; Q9NX90;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   12-OCT-2022, entry version 163.
DE   RecName: Full=Feline leukemia virus subgroup C receptor-related protein 2;
DE   AltName: Full=Calcium-chelate transporter;
DE            Short=CCT;
GN   Name=FLVCR2; Synonyms=C14orf58;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC   TISSUE=Pituitary;
RX   PubMed=14729055; DOI=10.1016/j.yexcr.2003.10.002;
RA   Brasier G., Tikellis C., Xuereb L., Craigie J., Casley D., Kovacs C.S.,
RA   Fudge N.J., Kalnins R., Cooper M.E., Wookey P.J.;
RT   "Novel hexad repeats conserved in a putative transporter with restricted
RT   expression in cell types associated with growth, calcium exchange and
RT   homeostasis.";
RL   Exp. Cell Res. 293:31-42(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Brown J., Pirani H., Tailor C.S.;
RT   "An aspartic acid in the presumptive extracellular loop six of subgroup C
RT   feline leukemia virus receptor FLVCR1 is involved in virus infection.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ALA-16.
RC   TISSUE=Placenta, and Umbilical cord blood;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   FUNCTION.
RX   PubMed=20823265; DOI=10.1128/mcb.00690-10;
RA   Duffy S.P., Shing J., Saraon P., Berger L.C., Eiden M.V., Wilde A.,
RA   Tailor C.S.;
RT   "The Fowler syndrome-associated protein FLVCR2 is an importer of heme.";
RL   Mol. Cell. Biol. 30:5318-5324(2010).
RN   [8]
RP   VARIANTS PVHH ARG-280; VAL-398 AND ARG-430.
RX   PubMed=20206334; DOI=10.1016/j.ajhg.2010.02.004;
RA   Meyer E., Ricketts C., Morgan N.V., Morris M.R., Pasha S., Tee L.J.,
RA   Rahman F., Bazin A., Bessieres B., Dechelotte P., Yacoubi M.T.,
RA   Al-Adnani M., Marton T., Tannahill D., Trembath R.C., Fallet-Bianco C.,
RA   Cox P., Williams D., Maher E.R.;
RT   "Mutations in FLVCR2 are associated with proliferative vasculopathy and
RT   hydranencephaly-hydrocephaly syndrome (Fowler syndrome).";
RL   Am. J. Hum. Genet. 86:471-478(2010).
RN   [9]
RP   VARIANTS PVHH 110-ASN--PHE-112 DELINS ILE; VAL-326 AND VAL-398.
RX   PubMed=20518025; DOI=10.1002/humu.21293;
RA   Lalonde E., Albrecht S., Ha K.C., Jacob K., Bolduc N., Polychronakos C.,
RA   Dechelotte P., Majewski J., Jabado N.;
RT   "Unexpected allelic heterogeneity and spectrum of mutations in Fowler
RT   syndrome revealed by next-generation exome sequencing.";
RL   Hum. Mutat. 31:918-923(2010).
RN   [10]
RP   VARIANTS PVHH HIS-84; ARG-352; VAL-398; ARG-412 AND MET-430.
RX   PubMed=20690116; DOI=10.1002/humu.21329;
RA   Thomas S., Encha-Razavi F., Devisme L., Etchevers H.,
RA   Bessieres-Grattagliano B., Goudefroye G., Elkhartoufi N., Pateau E.,
RA   Ichkou A., Bonniere M., Marcorelle P., Parent P., Manouvrier S., Holder M.,
RA   Laquerriere A., Loeuillet L., Roume J., Martinovic J., Mougou-Zerelli S.,
RA   Gonzales M., Meyer V., Wessner M., Feysot C.B., Nitschke P., Leticee N.,
RA   Munnich A., Lyonnet S., Wookey P., Gyapay G., Foliguet B., Vekemans M.,
RA   Attie-Bitach T.;
RT   "High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2
RT   deletions and mutations in lethal cerebral vasculopathy.";
RL   Hum. Mutat. 31:1134-1141(2010).
CC   -!- FUNCTION: Acts as an importer of heme. Also acts as a transporter for a
CC       calcium-chelator complex, important for growth and calcium metabolism.
CC       {ECO:0000269|PubMed:20823265}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UPI3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UPI3-2; Sequence=VSP_043048, VSP_043049;
CC   -!- TISSUE SPECIFICITY: Expressed in non-hematopoietic tissues, with
CC       relative abundant expression in brain, placenta, lung, liver and
CC       kidney. Also expressed in hematopoietic tissues (fetal liver, spleen,
CC       lymph node, thymus, leukocytes and bone marrow). Found in acidophil
CC       cells of the pituitary that secrete growth hormone and prolactin.
CC   -!- DISEASE: Proliferative vasculopathy and hydranencephaly-hydrocephaly
CC       syndrome (PVHH) [MIM:225790]: A rare prenatally lethal disorder
CC       characterized by hydranencephaly, a distinctive glomerular vasculopathy
CC       in the central nervous system and retina, and diffuse ischemic lesions
CC       of the brain stem, basal ganglia, and spinal cord with calcifications.
CC       Hydranencephaly is a condition where the greater portions of the
CC       cerebral hemispheres and corpus striatum are replaced by cerebrospinal
CC       fluid and glial tissue. {ECO:0000269|PubMed:20206334,
CC       ECO:0000269|PubMed:20518025, ECO:0000269|PubMed:20690116}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Feline
CC       leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB55381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY260572; AAP86633.1; -; mRNA.
DR   EMBL; AY260577; AAP86638.1; -; mRNA.
DR   EMBL; AF456126; AAO15528.1; -; mRNA.
DR   EMBL; AK000378; BAA91126.1; -; mRNA.
DR   EMBL; AK027804; BAB55381.1; ALT_INIT; mRNA.
DR   EMBL; AK297002; BAH12471.1; -; mRNA.
DR   EMBL; AC007182; AAD51374.1; -; Genomic_DNA.
DR   EMBL; CH471061; EAW81235.1; -; Genomic_DNA.
DR   EMBL; BC019087; AAH19087.1; -; mRNA.
DR   CCDS; CCDS55933.1; -. [Q9UPI3-2]
DR   CCDS; CCDS9844.1; -. [Q9UPI3-1]
DR   RefSeq; NP_001182212.1; NM_001195283.1. [Q9UPI3-2]
DR   RefSeq; NP_060261.2; NM_017791.2. [Q9UPI3-1]
DR   AlphaFoldDB; Q9UPI3; -.
DR   SMR; Q9UPI3; -.
DR   BioGRID; 120777; 30.
DR   IntAct; Q9UPI3; 3.
DR   STRING; 9606.ENSP00000238667; -.
DR   TCDB; 2.A.1.28.4; the major facilitator superfamily (mfs).
DR   iPTMnet; Q9UPI3; -.
DR   PhosphoSitePlus; Q9UPI3; -.
DR   BioMuta; FLVCR2; -.
DR   DMDM; 46396034; -.
DR   jPOST; Q9UPI3; -.
DR   MassIVE; Q9UPI3; -.
DR   MaxQB; Q9UPI3; -.
DR   PaxDb; Q9UPI3; -.
DR   PeptideAtlas; Q9UPI3; -.
DR   PRIDE; Q9UPI3; -.
DR   ProteomicsDB; 85372; -. [Q9UPI3-1]
DR   ProteomicsDB; 85373; -. [Q9UPI3-2]
DR   Antibodypedia; 51434; 129 antibodies from 21 providers.
DR   DNASU; 55640; -.
DR   Ensembl; ENST00000238667.9; ENSP00000238667.4; ENSG00000119686.10. [Q9UPI3-1]
DR   Ensembl; ENST00000539311.5; ENSP00000443439.1; ENSG00000119686.10. [Q9UPI3-2]
DR   GeneID; 55640; -.
DR   KEGG; hsa:55640; -.
DR   MANE-Select; ENST00000238667.9; ENSP00000238667.4; NM_017791.3; NP_060261.2.
DR   UCSC; uc001xrs.3; human. [Q9UPI3-1]
DR   CTD; 55640; -.
DR   DisGeNET; 55640; -.
DR   GeneCards; FLVCR2; -.
DR   HGNC; HGNC:20105; FLVCR2.
DR   HPA; ENSG00000119686; Low tissue specificity.
DR   MalaCards; FLVCR2; -.
DR   MIM; 225790; phenotype.
DR   MIM; 610865; gene.
DR   neXtProt; NX_Q9UPI3; -.
DR   OpenTargets; ENSG00000119686; -.
DR   Orphanet; 221126; Fowler vasculopaty.
DR   PharmGKB; PA162388720; -.
DR   VEuPathDB; HostDB:ENSG00000119686; -.
DR   eggNOG; KOG2563; Eukaryota.
DR   GeneTree; ENSGT01030000234625; -.
DR   HOGENOM; CLU_023132_0_1_1; -.
DR   InParanoid; Q9UPI3; -.
DR   OMA; AINWMST; -.
DR   OrthoDB; 702737at2759; -.
DR   PhylomeDB; Q9UPI3; -.
DR   TreeFam; TF314292; -.
DR   PathwayCommons; Q9UPI3; -.
DR   SignaLink; Q9UPI3; -.
DR   BioGRID-ORCS; 55640; 29 hits in 1071 CRISPR screens.
DR   ChiTaRS; FLVCR2; human.
DR   GenomeRNAi; 55640; -.
DR   Pharos; Q9UPI3; Tbio.
DR   PRO; PR:Q9UPI3; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q9UPI3; protein.
DR   Bgee; ENSG00000119686; Expressed in secondary oocyte and 134 other tissues.
DR   ExpressionAtlas; Q9UPI3; baseline and differential.
DR   Genevisible; Q9UPI3; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IDA:UniProtKB.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IDA:UniProtKB.
DR   GO; GO:0097037; P:heme export; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Disease variant; Membrane;
KW   Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..526
FT                   /note="Feline leukemia virus subgroup C receptor-related
FT                   protein 2"
FT                   /id="PRO_0000084846"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          25..30
FT                   /note="1"
FT   REPEAT          31..36
FT                   /note="2"
FT   REPEAT          37..42
FT                   /note="3"
FT   REPEAT          43..48
FT                   /note="4"
FT   REPEAT          49..54
FT                   /note="5"
FT   REPEAT          55..60
FT                   /note="6; approximate"
FT   REPEAT          61..66
FT                   /note="7; approximate"
FT   REPEAT          67..72
FT                   /note="8"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          25..72
FT                   /note="8 X 6 AA tandem repeats of P-S-[VS]-S-[VIAG]-[HNP]"
FT   REGION          500..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..514
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         515
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91X85"
FT   VAR_SEQ         1..18
FT                   /note="MVNEGPNQEESDDTPVPE -> MSADNSSTICVCRSVRQE (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_043048"
FT   VAR_SEQ         19..223
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_043049"
FT   VARIANT         16
FT                   /note="V -> A (in dbSNP:rs2287015)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_018271"
FT   VARIANT         84
FT                   /note="R -> H (in PVHH)"
FT                   /evidence="ECO:0000269|PubMed:20690116"
FT                   /id="VAR_064410"
FT   VARIANT         110..112
FT                   /note="NIF -> I (in PVHH)"
FT                   /evidence="ECO:0000269|PubMed:20518025"
FT                   /id="VAR_064411"
FT   VARIANT         280
FT                   /note="P -> R (in PVHH; dbSNP:rs267606823)"
FT                   /evidence="ECO:0000269|PubMed:20206334"
FT                   /id="VAR_064043"
FT   VARIANT         326
FT                   /note="A -> V (in PVHH; dbSNP:rs267606824)"
FT                   /evidence="ECO:0000269|PubMed:20518025"
FT                   /id="VAR_064412"
FT   VARIANT         352
FT                   /note="T -> R (in PVHH)"
FT                   /evidence="ECO:0000269|PubMed:20690116"
FT                   /id="VAR_064413"
FT   VARIANT         398
FT                   /note="L -> V (in PVHH; dbSNP:rs267606822)"
FT                   /evidence="ECO:0000269|PubMed:20206334,
FT                   ECO:0000269|PubMed:20518025, ECO:0000269|PubMed:20690116"
FT                   /id="VAR_064044"
FT   VARIANT         412
FT                   /note="G -> R (in PVHH)"
FT                   /evidence="ECO:0000269|PubMed:20690116"
FT                   /id="VAR_064414"
FT   VARIANT         430
FT                   /note="T -> M (in PVHH; dbSNP:rs267606825)"
FT                   /evidence="ECO:0000269|PubMed:20690116"
FT                   /id="VAR_064415"
FT   VARIANT         430
FT                   /note="T -> R (in PVHH; dbSNP:rs267606825)"
FT                   /evidence="ECO:0000269|PubMed:20206334"
FT                   /id="VAR_064045"
FT   VARIANT         481
FT                   /note="A -> T (in dbSNP:rs35126362)"
FT                   /id="VAR_050299"
FT   CONFLICT        419
FT                   /note="L -> H (in Ref. 3; BAB55381)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        439
FT                   /note="S -> F (in Ref. 3; BAA91126)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   526 AA;  57241 MW;  D233C07350B17870 CRC64;
     MVNEGPNQEE SDDTPVPESA LQADPSVSVH PSVSVHPSVS INPSVSVHPS SSAHPSALAQ
     PSGLAHPSSS GPEDLSVIKV SRRRWAVVLV FSCYSMCNSF QWIQYGSINN IFMHFYGVSA
     FAIDWLSMCY MLTYIPLLLP VAWLLEKFGL RTIALTGSAL NCLGAWVKLG SLKPHLFPVT
     VVGQLICSVA QVFILGMPSR IASVWFGANE VSTACSVAVF GNQLGIAIGF LVPPVLVPNI
     EDRDELAYHI SIMFYIIGGV ATLLLILVII VFKEKPKYPP SRAQSLSYAL TSPDASYLGS
     IARLFKNLNF VLLVITYGLN AGAFYALSTL LNRMVIWHYP GEEVNAGRIG LTIVIAGMLG
     AVISGIWLDR SKTYKETTLV VYIMTLVGMV VYTFTLNLGH LWVVFITAGT MGFFMTGYLP
     LGFEFAVELT YPESEGISSG LLNISAQVFG IIFTISQGQI IDNYGTKPGN IFLCVFLTLG
     AALTAFIKAD LRRQKANKET LENKLQEEEE ESNTSKVPTA VSEDHL
//