ID CSN3_HUMAN Reviewed; 423 AA. AC Q9UNS2; B2R683; B4DY81; O43191; Q7LDR6; DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 13-NOV-2019, entry version 174. DE RecName: Full=COP9 signalosome complex subunit 3; DE Short=SGN3; DE Short=Signalosome subunit 3; DE AltName: Full=JAB1-containing signalosome subunit 3; GN Name=COPS3; Synonyms=CSN3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, RP FUNCTION, AND SUBCELLULAR LOCATION. RC TISSUE=Cervix carcinoma; RX PubMed=9535219; DOI=10.1096/fasebj.12.6.469; RA Seeger M., Kraft R., Ferrell K., Bech-Otschir D., Dumdey R., RA Schade R., Gordon C., Naumann M., Dubiel W.; RT "A novel protein complex involved in signal transduction possessing RT similarities to 26S proteasome subunits."; RL FASEB J. 12:469-478(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Brain; RX PubMed=10191102; DOI=10.1006/geno.1998.5748; RA Potocki L., Chen K.-S., Lupski J.R.; RT "Subunit 3 of the COP9 signal transduction complex is conserved from RT plants to humans and maps within the Smith-Magenis syndrome critical RT region in 17p11.2."; RL Genomics 57:180-182(1999). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Hippocampus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PROTEIN SEQUENCE OF 2-13 (ISOFORM 1). RC TISSUE=Platelet; RX PubMed=12665801; DOI=10.1038/nbt810; RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., RA Thomas G.R., Vandekerckhove J.; RT "Exploring proteomes and analyzing protein processing by mass RT spectrometric identification of sorted N-terminal peptides."; RL Nat. Biotechnol. 21:566-569(2003). RN [8] RP PROTEIN SEQUENCE OF 2-13; 31-37; 244-251 AND 313-336 (ISOFORM 1), RP CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND RP IDENTIFICATION BY MASS SPECTROMETRY. RC TISSUE=Cervix carcinoma, and Platelet; RA Bienvenut W.V., Quadroni M.; RL Submitted (OCT-2005) to UniProtKB. RN [9] RP FUNCTION. RX PubMed=11285227; DOI=10.1093/emboj/20.7.1630; RA Bech-Otschir D., Kraft R., Huang X., Henklein P., Kapelari B., RA Pollmann C., Dubiel W.; RT "COP9 signalosome-specific phosphorylation targets p53 to degradation RT by the ubiquitin system."; RL EMBO J. 20:1630-1639(2001). RN [10] RP INTERACTION WITH IKBKG. RX PubMed=11418127; DOI=10.1016/s0014-5793(01)02535-2; RA Hong X., Xu L.-G., Li X., Zhai Z., Shu H.-B.; RT "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced RT NF-kappaB activation."; RL FEBS Lett. 499:133-136(2001). RN [11] RP FUNCTION, AND COMPOSITION OF THE CSN COMPLEX. RX PubMed=11337588; DOI=10.1126/science.1059780; RA Lyapina S., Cope G., Shevchenko A., Serino G., Tsuge T., Zhou C., RA Wolf D.A., Wei N., Shevchenko A., Deshaies R.J.; RT "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome."; RL Science 292:1382-1385(2001). RN [12] RP INTERACTION WITH EIF3S6. RX PubMed=12220626; DOI=10.1016/s0014-5793(02)03147-2; RA Hoareau Alves K., Bochard V., Rety S., Jalinot P.; RT "Association of the mammalian proto-oncoprotein Int-6 with the three RT protein complexes eIF3, COP9 signalosome and 26S proteasome."; RL FEBS Lett. 527:15-21(2002). RN [13] RP FUNCTION. RX PubMed=12732143; DOI=10.1016/s0092-8674(03)00316-7; RA Groisman R., Polanowska J., Kuraoka I., Sawada J., Saijo M., RA Drapkin R., Kisselev A.F., Tanaka K., Nakatani Y.; RT "The ubiquitin ligase activity in the DDB2 and CSA complexes is RT differentially regulated by the COP9 signalosome in response to DNA RT damage."; RL Cell 113:357-367(2003). RN [14] RP FUNCTION, AND INTERACTION WITH CK2 AND PKD. RX PubMed=12628923; DOI=10.1093/emboj/cdg127; RA Uhle S., Medalia O., Waldron R., Dumdey R., Henklein P., RA Bech-Otschir D., Huang X., Berse M., Sperling J., Schade R., RA Dubiel W.; RT "Protein kinase CK2 and protein kinase D are associated with the COP9 RT signalosome."; RL EMBO J. 22:1302-1312(2003). RN [15] RP OVEREXPRESSION IN OSTEOSARCOMA. RX PubMed=12917637; DOI=10.1038/sj.onc.1206671; RA Henriksen J., Aagesen T.H., Maelandsmo G.M., Lothe R.A., Myklebost O., RA Forus A.; RT "Amplification and overexpression of COPS3 in osteosarcomas RT potentially target TP53 for proteasome-mediated degradation."; RL Oncogene 22:5358-5361(2003). RN [16] RP OVEREXPRESSION IN OSTEOSARCOMA. RX PubMed=15325100; DOI=10.1016/j.cancergencyto.2004.03.007; RA Van Dartel M., Hulsebos T.J.M.; RT "Amplification and overexpression of genes in 17p11.2 approximately RT p12 in osteosarcoma."; RL Cancer Genet. Cytogenet. 153:77-80(2004). RN [17] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Embryonic kidney; RX PubMed=17525332; DOI=10.1126/science.1140321; RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, RA Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., RA Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; RT "ATM and ATR substrate analysis reveals extensive protein networks RT responsive to DNA damage."; RL Science 316:1160-1166(2007). RN [18] RP IDENTIFICATION IN THE CSN COMPLEX, CLEAVAGE OF INITIATOR METHIONINE, RP ACETYLATION AT ALA-2, AND PHOSPHORYLATION AT SER-423. RX PubMed=18850735; DOI=10.1021/pr800574c; RA Fang L., Wang X., Yamoah K., Chen P.L., Pan Z.Q., Huang L.; RT "Characterization of the human COP9 signalosome complex using affinity RT purification and mass spectrometry."; RL J. Proteome Res. 7:4914-4925(2008). RN [19] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410 AND SER-423, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [20] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [21] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., RA Mann M.; RT "Quantitative phosphoproteomics reveals widespread full RT phosphorylation site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [22] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [23] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [24] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22223895; DOI=10.1074/mcp.m111.015131; RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., RA Meinnel T., Giglione C.; RT "Comparative large-scale characterisation of plant vs. mammal proteins RT reveals similar and idiosyncratic N-alpha acetylation features."; RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012). RN [25] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., RA Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N- RT terminal acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [26] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [27] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [28] RP COMPOSITION OF THE CSN COMPLEX, AND INTERACTION WITH COPS9. RX PubMed=26456823; DOI=10.1016/j.celrep.2015.09.021; RA Rozen S., Fuezesi-Levi M.G., Ben-Nissan G., Mizrachi L., RA Gabashvili A., Levin Y., Ben-Dor S., Eisenstein M., Sharon M.; RT "CSNAP is a stoichiometric subunit of the COP9 signalosome."; RL Cell Rep. 13:585-598(2015). RN [29] RP INTERACTION WITH ERCC6. RX PubMed=26030138; DOI=10.1371/journal.pone.0128558; RA Nicolai S., Filippi S., Caputo M., Cipak L., Gregan J., Ammerer G., RA Frontini M., Willems D., Prantera G., Balajee A.S., RA Proietti-De-Santis L.; RT "Identification of Novel Proteins Co-Purifying with Cockayne Syndrome RT Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and RT Chromatin Dynamics."; RL PLoS ONE 10:E0128558-E0128558(2015). CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a CC complex involved in various cellular and developmental processes. CC The CSN complex is an essential regulator of the ubiquitin (Ubl) CC conjugation pathway by mediating the deneddylation of the cullin CC subunits of SCF-type E3 ligase complexes, leading to decrease the CC Ubl ligase activity of SCF-type complexes such as SCF, CSA or CC DDB2. The complex is also involved in phosphorylation of p53/TP53, CC c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via CC its association with CK2 and PKD kinases. CSN-dependent CC phosphorylation of TP53 and JUN promotes and protects degradation CC by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, CC ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, CC ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. CC -!- SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, CC COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 CC and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). In the CC complex, it probably interacts directly with COPS1, COPS4, COPS8 CC and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). Interacts CC with CK2 and PKD (PubMed:12628923). Interacts with the translation CC initiation factor EIF3S6 and IKBKG (PubMed:11418127, CC PubMed:12220626). Interacts with ERCC6 (PubMed:26030138). CC {ECO:0000269|PubMed:11418127, ECO:0000269|PubMed:12220626, CC ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:18850735, CC ECO:0000269|PubMed:26030138, ECO:0000269|PubMed:26456823}. CC -!- INTERACTION: CC P10398:ARAF; NbExp=3; IntAct=EBI-350590, EBI-365961; CC P61201:COPS2; NbExp=11; IntAct=EBI-350590, EBI-1050386; CC Q92905:COPS5; NbExp=13; IntAct=EBI-350590, EBI-594661; CC Q7L5N1:COPS6; NbExp=19; IntAct=EBI-350590, EBI-486838; CC Q9UBW8:COPS7A; NbExp=10; IntAct=EBI-350590, EBI-712982; CC Q99627:COPS8; NbExp=10; IntAct=EBI-350590, EBI-2510102; CC Q9Y6K9:IKBKG; NbExp=2; IntAct=EBI-350590, EBI-81279; CC Q07889:SOS1; NbExp=3; IntAct=EBI-350590, EBI-297487; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. CC Nucleus {ECO:0000269|PubMed:9535219}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9UNS2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9UNS2-2; Sequence=VSP_044271; CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed at high level in CC heart and skeletal muscle. {ECO:0000269|PubMed:10191102}. CC -!- MISCELLANEOUS: Amplified and overexpressed in some osteosarcomas CC (OS), suggesting that it may participate in TP53 degradation in CC OS. CC -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC14197.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF031647; AAC14197.1; ALT_FRAME; mRNA. DR EMBL; AF098109; AAD41247.1; -; mRNA. DR EMBL; AK312476; BAG35380.1; -; mRNA. DR EMBL; AK302304; BAG63643.1; -; mRNA. DR EMBL; AK316400; BAH14771.1; -; mRNA. DR EMBL; AC055811; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471196; EAW55712.1; -; Genomic_DNA. DR EMBL; BC001891; AAH01891.1; -; mRNA. DR CCDS; CCDS11183.1; -. [Q9UNS2-1] DR CCDS; CCDS56022.1; -. [Q9UNS2-2] DR RefSeq; NP_001186054.1; NM_001199125.1. [Q9UNS2-2] DR RefSeq; NP_001303283.1; NM_001316354.1. DR RefSeq; NP_001303284.1; NM_001316355.1. DR RefSeq; NP_001303285.1; NM_001316356.1. DR RefSeq; NP_001303286.1; NM_001316357.1. DR RefSeq; NP_001303287.1; NM_001316358.1. DR RefSeq; NP_003644.2; NM_003653.3. [Q9UNS2-1] DR RefSeq; XP_005256894.1; XM_005256837.4. [Q9UNS2-2] DR PDB; 4D10; X-ray; 3.80 A; C/K=1-423. DR PDB; 4D18; X-ray; 4.08 A; C/K=1-423. DR PDB; 4WSN; X-ray; 5.50 A; C/K/S/a/i/q=1-423. DR PDB; 6R6H; EM; 8.40 A; C=1-383. DR PDB; 6R7F; EM; 8.20 A; C=1-403. DR PDB; 6R7H; EM; 8.80 A; C=1-403. DR PDB; 6R7I; EM; 5.90 A; C=3-403. DR PDB; 6R7N; EM; 6.50 A; C=3-403. DR PDBsum; 4D10; -. DR PDBsum; 4D18; -. DR PDBsum; 4WSN; -. DR PDBsum; 6R6H; -. DR PDBsum; 6R7F; -. DR PDBsum; 6R7H; -. DR PDBsum; 6R7I; -. DR PDBsum; 6R7N; -. DR SMR; Q9UNS2; -. DR BioGrid; 114103; 112. DR ComplexPortal; CPX-1870; COP9 signalosome variant 1. DR ComplexPortal; CPX-1871; COP9 signalosome variant 2. DR CORUM; Q9UNS2; -. DR DIP; DIP-32478N; -. DR IntAct; Q9UNS2; 62. DR MINT; Q9UNS2; -. DR STRING; 9606.ENSP00000268717; -. DR iPTMnet; Q9UNS2; -. DR PhosphoSitePlus; Q9UNS2; -. DR SwissPalm; Q9UNS2; -. DR BioMuta; COPS3; -. DR DMDM; 55976621; -. DR EPD; Q9UNS2; -. DR jPOST; Q9UNS2; -. DR MassIVE; Q9UNS2; -. DR PaxDb; Q9UNS2; -. DR PeptideAtlas; Q9UNS2; -. DR PRIDE; Q9UNS2; -. DR ProteomicsDB; 5506; -. DR ProteomicsDB; 85328; -. [Q9UNS2-1] DR DNASU; 8533; -. DR Ensembl; ENST00000268717; ENSP00000268717; ENSG00000141030. [Q9UNS2-1] DR Ensembl; ENST00000539941; ENSP00000437606; ENSG00000141030. [Q9UNS2-2] DR GeneID; 8533; -. DR KEGG; hsa:8533; -. DR UCSC; uc002grd.4; human. [Q9UNS2-1] DR CTD; 8533; -. DR DisGeNET; 8533; -. DR GeneCards; COPS3; -. DR HGNC; HGNC:2239; COPS3. DR HPA; HPA021997; -. DR HPA; HPA050557; -. DR MIM; 604665; gene. DR neXtProt; NX_Q9UNS2; -. DR OpenTargets; ENSG00000141030; -. DR PharmGKB; PA26755; -. DR eggNOG; KOG2582; Eukaryota. DR eggNOG; ENOG410XRKY; LUCA. DR GeneTree; ENSGT00940000153653; -. DR HOGENOM; HOG000030451; -. DR InParanoid; Q9UNS2; -. DR KO; K12177; -. DR OMA; NHYHDLV; -. DR OrthoDB; 929822at2759; -. DR PhylomeDB; Q9UNS2; -. DR TreeFam; TF101146; -. DR Reactome; R-HSA-5696394; DNA Damage Recognition in GG-NER. DR Reactome; R-HSA-6781823; Formation of TC-NER Pre-Incision Complex. DR Reactome; R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis. DR Reactome; R-HSA-8951664; Neddylation. DR SignaLink; Q9UNS2; -. DR SIGNOR; Q9UNS2; -. DR ChiTaRS; COPS3; human. DR GeneWiki; COP9_signalosome_complex_subunit_3; -. DR GenomeRNAi; 8533; -. DR Pharos; Q9UNS2; -. DR PRO; PR:Q9UNS2; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000141030; Expressed in 234 organ(s), highest expression level in testis. DR ExpressionAtlas; Q9UNS2; baseline and differential. DR Genevisible; Q9UNS2; HS. DR GO; GO:0008180; C:COP9 signalosome; IDA:UniProtKB. DR GO; GO:0005737; C:cytoplasm; TAS:ProtInc. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0000715; P:nucleotide-excision repair, DNA damage recognition; TAS:Reactome. DR GO; GO:0043687; P:post-translational protein modification; TAS:Reactome. DR GO; GO:0000338; P:protein deneddylation; IDA:UniProtKB. DR GO; GO:0009416; P:response to light stimulus; TAS:ProtInc. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central. DR Gene3D; 1.10.10.10; -; 1. DR InterPro; IPR037753; CSN3. DR InterPro; IPR000717; PCI_dom. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1. DR Pfam; PF01399; PCI; 1. DR SMART; SM00088; PINT; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR PROSITE; PS50250; PCI; 1. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Alternative splicing; Complete proteome; KW Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; KW Reference proteome; Signalosome. FT INIT_MET 1 1 Removed. {ECO:0000244|PubMed:19413330, FT ECO:0000244|PubMed:22223895, FT ECO:0000244|PubMed:22814378, FT ECO:0000269|PubMed:18850735, FT ECO:0000269|Ref.8}. FT CHAIN 2 423 COP9 signalosome complex subunit 3. FT /FTId=PRO_0000120978. FT DOMAIN 197 365 PCI. {ECO:0000255|PROSITE- FT ProRule:PRU01185}. FT MOD_RES 2 2 N-acetylalanine. FT {ECO:0000244|PubMed:19413330, FT ECO:0000244|PubMed:22223895, FT ECO:0000244|PubMed:22814378, FT ECO:0000269|PubMed:18850735, FT ECO:0000269|Ref.8}. FT MOD_RES 407 407 Phosphoserine. FT {ECO:0000250|UniProtKB:O88543}. FT MOD_RES 410 410 Phosphoserine. FT {ECO:0000244|PubMed:18669648, FT ECO:0000244|PubMed:23186163}. FT MOD_RES 423 423 Phosphoserine. FT {ECO:0000244|PubMed:18669648, FT ECO:0000244|PubMed:20068231, FT ECO:0000244|PubMed:21406692, FT ECO:0000269|PubMed:18850735}. FT VAR_SEQ 1 20 Missing (in isoform 2). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_044271. SQ SEQUENCE 423 AA; 47873 MW; 1D371050C7D7BF8D CRC64; MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG IGILKQAIDK MQMNTNQLTS IHADLCQLCL LAKCFKPALP YLDVDMMDIC KENGAYDAKH FLCYYYYGGM IYTGLKNFER ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ LPKYTSQIVG RFIKPLSNAY HELAQVYSTN NPSELRNLVN KHSETFTRDN NMGLVKQCLS SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS INQKDGMVSF HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN PQFVQKSMGS QEDDSGNKPS SYS //