ID   PALD_HUMAN              Reviewed;         856 AA.
AC   Q9ULE6; B2RMS1; B9EGC6; Q5JTK7; Q5JTK8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 3.
DT   15-FEB-2017, entry version 106.
DE   RecName: Full=Paladin;
GN   Name=PALD1; Synonyms=KIAA1274, PALD;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-141.
RC   TISSUE=Brain;
RX   PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA   Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XV.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 6:337-345(1999).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-141.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   MYRISTOYLATION AT GLY-2.
RX   PubMed=20213681; DOI=10.1002/pmic.200900783;
RA   Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,
RA   Tsunasawa S., Utsumi T.;
RT   "Strategy for comprehensive identification of human N-myristoylated
RT   proteins using an insect cell-free protein synthesis system.";
RL   Proteomics 10:1780-1793(2010).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [7]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=22354871; DOI=10.1002/dvdy.23753;
RA   Wallgard E., Nitzsche A., Larsson J., Guo X., Dieterich L.C.,
RA   Dimberg A., Olofsson T., Ponten F.C., Makinen T., Kalen M.,
RA   Hellstrom M.;
RT   "Paladin (X99384) is expressed in the vasculature and shifts from
RT   endothelial to vascular smooth muscle cells during mouse
RT   development.";
RL   Dev. Dyn. 241:770-786(2012).
CC   -!- INTERACTION:
CC       Q92985:IRF7; NbExp=2; IntAct=EBI-3957166, EBI-968267;
CC       A2APF7:Zbp1 (xeno); NbExp=2; IntAct=EBI-3957166, EBI-6115394;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000269|PubMed:22354871}.
CC   -!- TISSUE SPECIFICITY: Expressed in endothelial cells, and in certain
CC       larger vessels, in mural cells. In the brain, possibly expressed
CC       in microglia. Expressed in peripheral blood mononuclear cells (at
CC       protein level). {ECO:0000269|PubMed:22354871}.
CC   -!- SIMILARITY: Belongs to the paladin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA86588.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=CAI41274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB033100; BAA86588.2; ALT_INIT; mRNA.
DR   EMBL; AL355344; CAI41274.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC022532; CAI41274.1; JOINED; Genomic_DNA.
DR   EMBL; AL355344; CAI41275.1; -; Genomic_DNA.
DR   EMBL; BC136375; AAI36376.1; -; mRNA.
DR   EMBL; BC136376; AAI36377.1; -; mRNA.
DR   CCDS; CCDS31215.1; -.
DR   RefSeq; NP_055246.2; NM_014431.2.
DR   RefSeq; XP_011537939.1; XM_011539637.2.
DR   RefSeq; XP_011537940.1; XM_011539638.2.
DR   RefSeq; XP_016871561.1; XM_017016072.1.
DR   UniGene; Hs.202351; -.
DR   ProteinModelPortal; Q9ULE6; -.
DR   BioGrid; 118028; 10.
DR   IntAct; Q9ULE6; 6.
DR   STRING; 9606.ENSP00000263563; -.
DR   iPTMnet; Q9ULE6; -.
DR   PhosphoSitePlus; Q9ULE6; -.
DR   BioMuta; PALD1; -.
DR   DMDM; 146325028; -.
DR   EPD; Q9ULE6; -.
DR   MaxQB; Q9ULE6; -.
DR   PaxDb; Q9ULE6; -.
DR   PeptideAtlas; Q9ULE6; -.
DR   PRIDE; Q9ULE6; -.
DR   Ensembl; ENST00000263563; ENSP00000263563; ENSG00000107719.
DR   GeneID; 27143; -.
DR   KEGG; hsa:27143; -.
DR   UCSC; uc001jrd.5; human.
DR   CTD; 27143; -.
DR   DisGeNET; 27143; -.
DR   GeneCards; PALD1; -.
DR   H-InvDB; HIX0008898; -.
DR   HGNC; HGNC:23530; PALD1.
DR   HPA; HPA015696; -.
DR   HPA; HPA017343; -.
DR   MIM; 614656; gene.
DR   neXtProt; NX_Q9ULE6; -.
DR   OpenTargets; ENSG00000107719; -.
DR   PharmGKB; PA134986569; -.
DR   eggNOG; ENOG410IIZG; Eukaryota.
DR   eggNOG; ENOG410YSN6; LUCA.
DR   GeneTree; ENSGT00390000005448; -.
DR   HOGENOM; HOG000068079; -.
DR   HOVERGEN; HBG108231; -.
DR   InParanoid; Q9ULE6; -.
DR   OMA; LECDGHT; -.
DR   OrthoDB; EOG091G01EJ; -.
DR   PhylomeDB; Q9ULE6; -.
DR   TreeFam; TF332292; -.
DR   GenomeRNAi; 27143; -.
DR   PRO; PR:Q9ULE6; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000107719; -.
DR   CleanEx; HS_KIAA1274; -.
DR   ExpressionAtlas; Q9ULE6; baseline and differential.
DR   Genevisible; Q9ULE6; HS.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.90.190.10; -; 5.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 3.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Lipoprotein; Myristate; Phosphoprotein;
KW   Polymorphism; Reference proteome.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    856       Paladin.
FT                                /FTId=PRO_0000286130.
FT   MOD_RES      86     86       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P70261}.
FT   LIPID         2      2       N-myristoyl glycine.
FT                                {ECO:0000269|PubMed:20213681}.
FT   VARIANT     141    141       S -> L (in dbSNP:rs2275060).
FT                                {ECO:0000269|PubMed:10574462,
FT                                ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_032076.
FT   VARIANT     721    721       R -> C (in dbSNP:rs3740447).
FT                                /FTId=VAR_032077.
FT   VARIANT     828    828       G -> R (in dbSNP:rs10999406).
FT                                /FTId=VAR_062188.
SQ   SEQUENCE   856 AA;  96754 MW;  BFCDD78DB2D4BE3B CRC64;
     MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS IIPNKVAPVV
     ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF LVRDVTEKMD VLGTVGSCGA
     PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY
     TPRDKQNLHE NLQGLGPGVR VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA
     IHGEDDLHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD
     AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL PMEQFQVIQS
     FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE GIRPESPAQG SGSRHSVWQR
     ALWSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA
     RGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR
     KVVWVSLREE AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF
     QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS KDPGTGFVFS
     CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH
     RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQEMRRLQLR SLQYLERYVC
     LILFNAYLHL EKADSWQRPF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW
     QEQSCSLEPS APEDLL
//