ID CDV3_HUMAN Reviewed; 258 AA. AC Q9UKY7; B3KUC2; Q96IP9; DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 25-MAY-2022, entry version 129. DE RecName: Full=Protein CDV3 homolog; GN Name=CDV3; Synonyms=H41; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RX PubMed=10497265; DOI=10.1093/nar/27.20.4008; RA Oh J.J., Grosshans D.R., Wong S.G., Slamon D.J.; RT "Identification of differentially expressed genes associated with HER-2/neu RT overexpression in human breast cancer cells."; RL Nucleic Acids Res. 27:4008-4017(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-244, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=15144186; DOI=10.1021/ac035352d; RA Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., RA Peters E.C.; RT "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from RT human T cells using immobilized metal affinity chromatography and tandem RT mass spectrometry."; RL Anal. Chem. 76:2763-2772(2004). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [7] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107 AND THR-182, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4; SER-8; SER-106; SER-107 RP AND THR-182, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9UKY7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9UKY7-2; Sequence=VSP_027760, VSP_027761; CC Name=3; CC IsoId=Q9UKY7-3; Sequence=VSP_041357, VSP_041358, VSP_041359; CC -!- TISSUE SPECIFICITY: Expression levels correlate with those of HER-2/neu CC in breast cancer cells. {ECO:0000269|PubMed:10497265}. CC -!- SIMILARITY: Belongs to the CDV3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF103803; AAF02423.1; -; mRNA. DR EMBL; AK096865; BAG53384.1; -; mRNA. DR EMBL; AC016255; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC007338; AAH07338.1; -; mRNA. DR CCDS; CCDS3079.1; -. [Q9UKY7-1] DR CCDS; CCDS46917.1; -. [Q9UKY7-2] DR CCDS; CCDS46918.1; -. [Q9UKY7-3] DR RefSeq; NP_001127894.1; NM_001134422.1. [Q9UKY7-2] DR RefSeq; NP_001127895.1; NM_001134423.2. [Q9UKY7-3] DR RefSeq; NP_001269691.1; NM_001282762.1. DR RefSeq; NP_001269692.1; NM_001282763.1. DR RefSeq; NP_001269693.1; NM_001282764.1. DR RefSeq; NP_001269694.1; NM_001282765.1. DR RefSeq; NP_060018.1; NM_017548.4. [Q9UKY7-1] DR AlphaFoldDB; Q9UKY7; -. DR BioGRID; 120726; 57. DR IntAct; Q9UKY7; 2. DR STRING; 9606.ENSP00000264993; -. DR GlyGen; Q9UKY7; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9UKY7; -. DR MetOSite; Q9UKY7; -. DR PhosphoSitePlus; Q9UKY7; -. DR BioMuta; CDV3; -. DR DMDM; 74721018; -. DR EPD; Q9UKY7; -. DR jPOST; Q9UKY7; -. DR MassIVE; Q9UKY7; -. DR MaxQB; Q9UKY7; -. DR PaxDb; Q9UKY7; -. DR PeptideAtlas; Q9UKY7; -. DR PRIDE; Q9UKY7; -. DR ProteomicsDB; 84914; -. [Q9UKY7-1] DR ProteomicsDB; 84915; -. [Q9UKY7-2] DR ProteomicsDB; 84916; -. [Q9UKY7-3] DR TopDownProteomics; Q9UKY7-1; -. [Q9UKY7-1] DR TopDownProteomics; Q9UKY7-2; -. [Q9UKY7-2] DR TopDownProteomics; Q9UKY7-3; -. [Q9UKY7-3] DR Antibodypedia; 33371; 83 antibodies from 16 providers. DR DNASU; 55573; -. DR Ensembl; ENST00000264993.8; ENSP00000264993.3; ENSG00000091527.17. DR Ensembl; ENST00000420115.6; ENSP00000413272.2; ENSG00000091527.17. [Q9UKY7-3] DR Ensembl; ENST00000431519.6; ENSP00000391955.2; ENSG00000091527.17. [Q9UKY7-2] DR GeneID; 55573; -. DR KEGG; hsa:55573; -. DR MANE-Select; ENST00000264993.8; ENSP00000264993.3; NM_017548.5; NP_060018.1. DR UCSC; uc003epp.5; human. [Q9UKY7-1] DR CTD; 55573; -. DR DisGeNET; 55573; -. DR GeneCards; CDV3; -. DR HGNC; HGNC:26928; CDV3. DR HPA; ENSG00000091527; Low tissue specificity. DR MIM; 618789; gene. DR neXtProt; NX_Q9UKY7; -. DR OpenTargets; ENSG00000091527; -. DR PharmGKB; PA142672138; -. DR VEuPathDB; HostDB:ENSG00000091527; -. DR eggNOG; ENOG502QRFT; Eukaryota. DR GeneTree; ENSGT00390000000805; -. DR HOGENOM; CLU_089760_1_0_1; -. DR InParanoid; Q9UKY7; -. DR OMA; KNENQDP; -. DR OrthoDB; 1568537at2759; -. DR PhylomeDB; Q9UKY7; -. DR TreeFam; TF315891; -. DR PathwayCommons; Q9UKY7; -. DR SignaLink; Q9UKY7; -. DR BioGRID-ORCS; 55573; 17 hits in 1078 CRISPR screens. DR ChiTaRS; CDV3; human. DR GenomeRNAi; 55573; -. DR Pharos; Q9UKY7; Tbio. DR PRO; PR:Q9UKY7; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q9UKY7; protein. DR Bgee; ENSG00000091527; Expressed in amniotic fluid and 250 other tissues. DR ExpressionAtlas; Q9UKY7; baseline and differential. DR Genevisible; Q9UKY7; HS. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR InterPro; IPR026806; CDV3. DR PANTHER; PTHR16284; PTHR16284; 1. DR Pfam; PF15359; CDV3; 1. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Cytoplasm; Phosphoprotein; KW Reference proteome. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0007744|PubMed:19413330" FT CHAIN 2..258 FT /note="Protein CDV3 homolog" FT /id="PRO_0000299560" FT REGION 1..234 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..17 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 77..94 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 105..123 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 177..202 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 203..234 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 2 FT /note="N-acetylalanine" FT /evidence="ECO:0007744|PubMed:19413330" FT MOD_RES 4 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 8 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 95 FT /note="Phosphotyrosine" FT /evidence="ECO:0000250|UniProtKB:Q4VAA2" FT MOD_RES 106 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 107 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231, FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT MOD_RES 182 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163" FT MOD_RES 190 FT /note="Phosphotyrosine" FT /evidence="ECO:0000250|UniProtKB:Q4VAA2" FT MOD_RES 244 FT /note="Phosphotyrosine" FT /evidence="ECO:0007744|PubMed:15144186" FT VAR_SEQ 1..102 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_041357" FT VAR_SEQ 209..213 FT /note="KDKEM -> NRYLK (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_027760" FT VAR_SEQ 210..212 FT /note="DKE -> YLK (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_041358" FT VAR_SEQ 213..258 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_041359" FT VAR_SEQ 214..258 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_027761" SQ SEQUENCE 258 AA; 27335 MW; 4BE95D0C217EE346 CRC64; MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG GAGAGTRPGD GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV QAMQISSEKE EDDNEKRQDP GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP PAPVIVTETP EPAMTSGVYR PPGARLTTTR KTPQGPPEIY SDTQFPSLQS TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL DNQYAVLENQ KSSHSQYN //